[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593008":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":48,"responsibleParty":62,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":10,"enrollmentInfo":81,"targetDuration":10,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":92,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Corticobasal Syndrome",null,"patients diagnosed with cbs",[13,14,15],"Diagnostic Test: C-11 ER176 Radiotracer","Diagnostic Test: C-11 PiB","Diagnostic Test: AV1451 Tau",{"label":17,"type":10,"description":18,"interventionNames":19},"Healthy Control","Healthy Control Volunteer",[13,14,15],[21,26,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"DIAGNOSTIC_TEST","C-11 ER176 Radiotracer","PET scan looking for inflammation",[9,17],{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"C-11 PiB","PET scan looking for amyloid protein",[9,17],{"type":22,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"AV1451 Tau","Pet scan looking for Tau protein",[9,17],[35],{"name":36,"affiliation":5,"role":37},"Jennifer Whitwell, Ph.D.","PRINCIPAL_INVESTIGATOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":10,"email":43},"Megan J Meyer, M.B.A.","CONTACT","507-293-1164","meyer.megan6@mayo.edu",{"name":45,"role":41,"phone":46,"phoneExt":10,"email":47},"Sarah M Boland, CCRP","507284-3863","boland.sarah@mayo.edu",[49],{"facility":5,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":10},"RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-92.4699,44.02163,{"lat":60,"lon":59},{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Jennifer Whitwell","Associate Consultant II",[67],{"name":68,"class":69},"National Institute on Aging (NIA)","NIH","100593008","imaging-studies-in-corticobasal-syndrome-100593008",false,"NCT07000851","Imaging Studies in Corticobasal Syndrome","Neuroinflammation, White Matter Integrity, AD Biomarkers and Pathology in Corticobasal Syndrome","I-CAN","Inclusion Criteria:\n\n* Age 18 years or older\n* Meet possible or probable CBS criteria\n\nExclusion Criteria:\n\n* Subjects will be excluded if MRI is contraindicated (due to implanted device, severe claustrophobia, etc)\n* Subjects will be excluded if they have a concurrent illnesses or structural abnormality that could account for the CBS syndrome\n* Subjects will be excluded if they have a mutation in the progranulin gene\n* Subjects will excluded if they have received anti-Aβ therapy\n* Women who are pregnant will be excluded\n* Subjects will be excluded if they are actively taking daily anti-inflammatory medications (NSAIDs, corticosteriods, etc)\n* Subjects will be excluded if they have generalized inflammatory condition and treatment with immunosuppressive, corticoid\u002Fglucocorticoid, steroidal or non-steroidal anti-inflammatory medication within 2 weeks of scanning",true,"ALL","18 Years",{"count":82,"type":83},80,"ESTIMATED","OBSERVATIONAL","The primary goal of this study is to investigate inflammation and white matter damage in corticobasal syndrome and determine whether these processes are related to each other. The investigator's will address our goal by using neuroimaging and blood plasma biomarkers, as well as molecular pathology.",[87,9,88,89,90,91],"Cortico Basal Degeneration","Corticobasal Syndrome(CBS)","Corticobasal Degeneration","Corticobasal Degeneration (CBD)","Corticobasal Syndrome (CBS)",[93,94,95,96,97,98],"neurodegeneration","neurodegenerative disease","cbs","cbd","corticobasal syndrome","corticobasal degeneration","2025-07-03",{"date":101,"type":102},"2025-07-07","ACTUAL",{"date":104,"type":102},"2025-06-25",{"date":106,"type":83},"2031-03-30",{"name":64,"class":6},1]