[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100493302":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":18,"responsibleParty":37,"collaborators":39,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":7,"eligibilityCriteria":48,"healthyVolunteers":45,"sex":49,"minAge":50,"maxAge":7,"enrollmentInfo":51,"targetDuration":7,"studyType":54,"phases":7,"briefSummary":55,"conditions":56,"keywords":61,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Johns Hopkins University","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Richard Leigh, MD","PRINCIPAL_INVESTIGATOR",[13],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Sera Chase","CONTACT","410-502-5355","schase15@jh.edu",[19],{"facility":20,"status":21,"city":22,"state":23,"zip":24,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"Kennedy Krieger Institute","RECRUITING","Baltimore","Maryland","21205","United States","US",{"type":28,"coordinates":29},"Point",[30,31],-76.61219,39.29038,{"lat":31,"lon":30},[34],{"name":35,"role":15,"phone":16,"phoneExt":7,"email":36},"Pooja Patel","ppate120@jhmi.edu",{"type":38,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[40],{"name":41,"class":42},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH","100493302","imaging-the-pathogenesis-of-cerebral-small-vessel-disease-100493302",false,"NCT05703386","Imaging the Pathogenesis of Cerebral Small Vessel Disease","Inclusion Criteria:\n\n* Clinical or radiographic evidence of ischemic stroke\n* One vascular risk factor (hypertension, hyperlipidemia, or diabetes)\n* Evidence of cerebral small vessel disease on MRI\n\nExclusion Criteria:\n\n* Inability to complete 3 research MRI scans over 1.25 years","ALL","18 Years",{"count":52,"type":53},50,"ESTIMATED","OBSERVATIONAL","Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.",[57,58,59,60],"Ischemic Stroke","Hypertension","Hyperlipidemias","Diabetes",[62,63,64,65,66,67],"Cerebral small vessel disease","Vascular cognitive impairment and dementia","White matter hyperintensities","Blood-brain barrier","Vascular risk factors","Ischemic stroke","2026-03-02",{"date":70,"type":71},"2026-03-03","ACTUAL",{"date":73,"type":71},"2022-11-08",{"date":75,"type":53},"2027-03-31",{"name":5,"class":6},1]