[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639381":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":44,"responsibleParty":58,"collaborators":25,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":25,"overallStatus":81,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Kafrelsheikh University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"platelet-rich fibrin group","EXPERIMENTAL","Immediate implant placement with subepithelial connective tissue grafting and adjunctive platelet-rich fibrin",[13],"Procedure: Platelet-Rich Fibrin",{"label":15,"type":10,"description":16,"interventionNames":17},"probiotics group","Immediate implant placement with subepithelial connective tissue grafting and adjunctive probiotics",[18],"Procedure: Probiotics",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Platelet-Rich Fibrin","platelet-rich fibrin will be prepared immediately before application using freshly drawn autologous venous blood and a standardized centrifugation protocol selected according to the equipment available in the study setting. The prepared PRF will be used as an adjunct to the immediate implant and subepithelial connective tissue grafting procedure according to the finalized protocol, either locally around the peri-implant site and\u002For in intimate relation to the grafted soft tissue to enhance healing and tissue maturation.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Probiotics","Probiotics probiotics will be administered as an adjunct to the immediate implant and subepithelial connective tissue grafting The mode of delivery, dose, and duration will be standardized for all patients allocated to this group.",[15],[31],{"name":32,"affiliation":5,"role":33},"walid elamrousy, phd","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"walid elamrousy, Phd","CONTACT","01029552024","waled_hammed@den.kfs.edu.eg",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},"Lamis OMER, bachelor","+249999005524","nour_hetata@den.kfs.edu.eg",[45],{"facility":46,"status":25,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":25},"faculty of dentistry, kafrelsheikh University","Kafr ash Shaykh","Kafrelsheikh","214312","Egypt","EG",{"type":53,"coordinates":54},"Point",[55,56],30.93991,31.11174,{"lat":56,"lon":55},{"type":33,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Walid Elamrousy","Professor of Periodontology Department Faculty of Oral and Dental Medicine,Kafrelsheikh University","100639381","immediate-implant-placement-with-subepithelial-connective-tissue-grafting-and-probiotics-100639381",false,"NCT07596758","Immediate Implant Placement With Subepithelial Connective Tissue Grafting and Probiotics","Comparative Evaluation of Platelet-Rich Fibrin Versus Probiotics as Adjuncts to Immediate Implant Placement Combined With Subepithelial Connective Tissue Grafting: Clinical, Biological, and Radiographic Peri-Implant Tissue Outcomes A Parallel-Arm Randomized Trial","Inclusion Criteria:\n\n* Adults aged 20 to 45 years.\n* Systemically healthy patients eligible for implant surgery.\n* Patients requiring extraction of a single non-restorable tooth indicated for immediate implant placement.\n* Implant sites located in the maxillary esthetic or para-esthetic zone.\n* Sites with sufficient apical and\u002For palatal bone to permit correct three-dimensional implant positioning and achieve adequate primary stability.\n* Sites suitable for simultaneous subepithelial connective tissue grafting.\n* Patients with acceptable oral hygiene and good compliance with periodontal and implant treatment.\n* Patients willing to attend all follow-up visits and comply with study instructions.\n\nExclusion Criteria:\n\n* Medically compromised patients or patients with systemic conditions that may contraindicate implant surgery or interfere with healing.\n* Smokers.\n* Pregnant or lactating women.\n* Patients with uncontrolled periodontal disease or poor oral hygiene.\n* Patients with acute infection at the intended implant site.\n* Patients with insufficient bone volume preventing immediate implant placement with adequate primary stability.\n* Patients with a history of head and neck radiotherapy or chemotherapy.\n* Patients receiving bisphosphonates or other medications known to affect bone metabolism or soft tissue healing.\n* Patients with parafunctional habits that may jeopardize implant stability or restorative success.\n* Patients unwilling or unable to complete the follow-up period.",true,"ALL","20 Years","45 Years",{"count":73,"type":74},22,"ESTIMATED","INTERVENTIONAL",[77],"NA","The present study aims to evaluate and compare the clinical, radiographic, and biological peri-implant tissue outcomes of platelet-rich fibrin versus probiotics as adjuncts to immediate implant placement combined with subepithelial connective tissue grafting in adults requiring single immediate implant placement.",[80],"Dental Implant Failed","NOT_YET_RECRUITING","2026-05-13",{"date":84,"type":85},"2026-05-19","ACTUAL",{"date":87,"type":74},"2026-05-14",{"date":89,"type":74},"2027-05-30",{"name":5,"class":6},1]