[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645190":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":42,"responsibleParty":58,"collaborators":31,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":31,"enrollmentInfo":69,"targetDuration":31,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":82,"overallStatus":86,"whyStopped":31,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Fundacin Biomedica Galicia Sur","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention with IVR","EXPERIMENTAL","The immersive virtual environment will be recreated using the Oculus Quest 3 system, distributed by Meta Platforms. This system is self-contained and requires only a virtual reality headset (HMD), two controllers, a Wi-Fi network, and some additional equipment. In each room, appropriate play areas will be defined based on the equipment, the software used, and the patient's health status at any given time. The virtual program will be structured progressively in terms of difficulty and complexity.",[13],"Device: Intervention with IVR",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","ACTIVE_COMPARATOR","Upon admission, the physiotherapist designs an exercise program tailored to the patient's condition, which includes:\n\n1. Breathing exercises to facilitate proper respiratory function and prevent potential respiratory infections. These include diaphragmatic breathing, costal breathing, free flexion exercises of the upper extremities combined with deep breathing, and free adduction\u002Fabduction exercises of the upper extremities combined with deep breathing.\n2. Resistance exercises with and without weights: to improve muscle metabolism, maintain the patient's physical capacity, and prevent sarcopenia.\n3. Aerobic exercises: to maintain cardiovascular function.",[19],"Other: Control",[21,28],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","The RVI intervention program will consist of the following phases:\n\n* Phase 1: Exposure to introductory scenarios and use of the RVI software and hardware, adaptation to virtual environments, observation of passive scenarios aimed at emotional balance, and interactive scenarios involving general mobility and neuromuscular activation. Week 1.\n* Phase 2: Progression towards tasks that improve response times and attentional mechanisms. Starting in week 2.\n* Phase 3: More complex multicomponent physical exercise based on boxing techniques, movements of the upper limbs, trunk, head, and lower limbs, coordination exercises, and cyclical cardiovascular exercise.",[9],[26,27],"Oculus Quest 3","Meta Platforms",{"type":6,"name":15,"description":29,"armGroupLabels":30,"otherNames":31},"Intervention based on the standard treatment program of activities of routine clinical practice: Breathing exercises, resistance exercises with and without weights and aerobic exercises.",[15],null,[33],{"name":34,"affiliation":35,"role":36},"Carmen Albo López, MD","Galicia Sur Health Research Institute","PRINCIPAL_INVESTIGATOR",[38],{"name":34,"role":39,"phone":40,"phoneExt":31,"email":41},"CONTACT","986 217 832","carmen.albo.lopez@sergas.es",[43],{"facility":44,"status":31,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Hospital Álvaro Cunqueiro (Vigo)","Vigo","Pontevedra","36312","Spain","ES",{"type":51,"coordinates":52},"Point",[53,54],-8.72264,42.23282,{"lat":54,"lon":53},[57],{"name":34,"role":39,"phone":40,"phoneExt":31,"email":41},{"type":59,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100645190","immersive-virtual-reality-applied-to-therapeutic-physical-exercise-in-cellular-therapy-100645190",false,"NCT07679958","Immersive Virtual Reality Applied to Therapeutic Physical Exercise in Cellular Therapy","RVI-ET","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Signed informed consent.\n* Patients eligible for CT scan at the Alvaro Cunqueiro Hospital.\n* Patients capable of performing therapeutic exercise independently, based on an objective initial functional assessment.\n* The clinical investigator, in their professional judgment, determines that the patient can adhere to all study requirements.\n\nExclusion Criteria:\n\n* Patients under 18 years of age.\n* Any medical condition or mental illness that could interfere with understanding HIP and CI.\n* Patients participating in another clinical trial.\n* Balance disorders that increase the risk of falls.\n* Severe visual and\u002For auditory impairments that prevent participation in the session.\n* History of vertigo, seizures, or epileptic fits.","ALL","18 Years",{"count":70,"type":71},144,"ESTIMATED","INTERVENTIONAL",[74],"NA","Cell therapy (CT), including hematopoietic stem cell transplantation (HSCT) and advanced CAR T-cell therapies, is used for the treatment of oncohematological and other diseases. HSCT is associated with treatment-related toxicities, including fatigue, muscle weakness, and reduced functional capacity due to intensive conditioning chemotherapy, immunosuppressive treatments, corticosteroids, and complications such as infections or graft-versus-host disease. Emotional symptoms, including anxiety, depression, fear, and frustration, also affect patients' recovery and ability to regain functional independence. Evidence indicates that exercise interventions improve emotional well-being, fatigue, quality of life, physical function, cardiovascular fitness, and muscle mass in patients with hematological malignancies and HSCT recipients.\n\nVirtual reality (VR) has emerged as an innovative tool in rehabilitation, supporting patient motivation, exercise guidance, and monitoring. Immersive virtual reality (IVR), through head-mounted displays and multisensory environments, enhances the sense of presence and engagement. Studies suggest that IVR-based exercise programs are feasible, improving functional abilities, quality of life, satisfaction, and adherence.\n\nSince 2017, a Therapeutic Exercise program for patients admitted for HSCT has been implemented at Álvaro Cunqueiro Hospital (Vigo) through collaboration between the Physiotherapy Unit and the Hematology Department. Before admission, patients undergo a physical assessment, receive an individualized exercise plan, education, and a therapeutic exercise guide. Based on clinical experience, the team hypothesizes that integrating IVR into therapeutic exercise may improve motivation, adherence, and emotional well-being during hospitalization.",[77,78,79,80,81],"Hematologic Diseases","Hematopoietic Stem Cell Transplantation","Cellular Therapy","Quality of Life","Oncologic Disorders",[83,84,85],"Therapeutic Exercise","Immersive virtual reality","Cellular therapy","NOT_YET_RECRUITING","2026-06-25",{"date":89,"type":90},"2026-07-01","ACTUAL",{"date":92,"type":71},"2026-07-24",{"date":94,"type":71},"2029-06-01",{"name":5,"class":6},1]