[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579597":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":59,"collaborators":10,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":10,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":82,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Jagiellonian University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Infertility",null,"Women aged 18-45 with idiopathic infertility\u002Frecurrent miscarriages",[13,14],"Diagnostic Test: Percentage distribution of immune system cells in peripheral blood","Diagnostic Test: Percentage distribution of immune system cells in endometrium",{"label":16,"type":10,"description":17,"interventionNames":18},"Normal fertility","Women aged 18-45 with a history of normal pregnancy obtained by spontaneous fertilization",[13,14],[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"DIAGNOSTIC_TEST","Percentage distribution of immune system cells in peripheral blood","Assessment of the percentage distribution of the immune system cell population in peripheral blood by flow cytometry",[9,16],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Percentage distribution of immune system cells in endometrium","Assessment of the percentage distribution of the immune system cell population in endometrium by flow cytometry",[9,16],[30],{"name":31,"affiliation":5,"role":32},"Kazimierz Pityński, Prof., PhD","STUDY_CHAIR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Iwona Gawron, PhD, MD","CONTACT","+48 124248570","iwona.gawron@uj.edu.pl",{"name":40,"role":36,"phone":37,"phoneExt":10,"email":41},"Robert Jach, Prof., PhD","jach@cm-uj.krakow.pl",[43],{"facility":44,"status":45,"city":46,"state":10,"zip":10,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Jagiellonian Univeristy","RECRUITING","Krakow","Poland","PL",{"type":50,"coordinates":51},"Point",[52,53],19.93658,50.06143,{"lat":53,"lon":52},[56],{"name":57,"role":36,"phone":37,"phoneExt":10,"email":58},"Iwona Gawron, Ph.D., M.D.","iwona.gawron@gmail.com",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Iwona Magdalena Gawron","PhD, MD, Principal Investigator","100579597","immune-cell-populations-in-the-endometrium-100579597",false,"NCT06826365","Immune Cell Populations in the Endometrium","Analysis of Immune Cell Populations in the Endometrium and Peripheral Blood in Women With Reduced and Normal Fertility","Inclusion Criteria:\n\n* age 18-45 years\n* idiopathic infertility\n* at least 2 miscarriages\n* other benign gynecological conditions subjected to endometrial sampling\n\nExclusion Criteria:\n\n* miscarriage within last 3 months\n* abdominal\u002Futerine surgery within last 3 months\n* viral\u002Fbacterial infection within last 3 months\n* antibiotic therapy within last 3 months","FEMALE","18 Years","45 Years",{"count":74,"type":75},50,"ESTIMATED","OBSERVATIONAL","Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood. In ovulatory cycles, changes occur in the populations of uterine lymphocytes, which may influence the receptivity of the endometrium and the implantation of the embryo. Particularly notable are the changes in natural killer (NK) cells, which reach their peak during the luteal phase and regulate the invasion of the trophoblast. The dominant NK cells exhibit a CD56bright phenotype and differ in cytokine profiles from peripheral blood cells. Cyclical changes also affect macrophages and T lymphocytes; however, it is unclear whether their proportions differ in women with reduced fertility. There is a need to investigate how the composition of lymphocytes in blood influences the populations in the endometrium. The aim of this study is to analyze the correlation between peripheral and endometrial lymphocytes in women with idiopathic infertility and recurrent miscarriages, compared to fertile women.",[79,80,81],"Infertility, Female","Recurrent Miscarriage","Gynecologic Disease",[83,84,85,86],"Idiopathic infertility","Endometrial immunology","Endometrial aspiration biopsy","Recurrent miscarriage","2026-03-17",{"date":89,"type":90},"2026-03-19","ACTUAL",{"date":92,"type":90},"2025-07-01",{"date":94,"type":75},"2026-06-30",{"name":5,"class":6},1]