[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622536":3},{"organization":4,"armGroups":7,"interventions":34,"overallOfficials":40,"centralContacts":45,"locations":54,"responsibleParty":79,"collaborators":39,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":89,"minAge":39,"maxAge":90,"enrollmentInfo":91,"targetDuration":39,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":104,"overallStatus":57,"whyStopped":39,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},{"fullName":5,"class":6},"Université Catholique de Louvain","OTHER",[8,13,18,22,26,30],{"label":9,"type":6,"description":10,"interventionNames":11},"Patients with precancerous lung lesions","Patients with precancerous lung lesions under clinical monitoring",[12],"Other: Peripheral Blood Collection for Immune Profiling",{"label":14,"type":15,"description":16,"interventionNames":17},"Lung cancer","ACTIVE_COMPARATOR","Patients with a diagnosis of lung cancer (all stages)",[12],{"label":19,"type":6,"description":20,"interventionNames":21},"Sarcoidosis and COPD","Patients with chronic inflammatory lung diseases",[12],{"label":23,"type":6,"description":24,"interventionNames":25},"Control group","Control group of volunteers without known lung disease",[12],{"label":27,"type":6,"description":28,"interventionNames":29},"chronic granulomatous disease","Children and adolescents weighing ≥10 kg with chronic granulomatous disease",[12],{"label":31,"type":6,"description":32,"interventionNames":33},"Adults undergoing orthopedic surgery following hip or femur fracture","Bone Marrow of Adults undergoing orthopedic surgery following hip or femur fracture",[12],[35],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":39},"Peripheral Blood Collection for Immune Profiling","Participants provide biological samples for immune profiling and translational research. Samples include peripheral blood and, when available from routine clinical care, additional specimens such as tumor tissue or rlymph node, bone marrow. No experimental treatments are given. Collected samples are analyzed to characterize immune cell populations and their functional and molecular features, with the aim of studying immune mechanisms involved in lung cancer, sarcoidosis, and COPD, as well as factors associated with disease progression and treatment response. All medical care and treatment decisions remain independent of study participation.",[31,23,14,9,19,27],null,[41],{"name":42,"affiliation":43,"role":44},"Frank Aboubakar Nana, MD; PhD","Cliniques universistaires saint Luc","STUDY_DIRECTOR",[46,50],{"name":42,"role":47,"phone":48,"phoneExt":39,"email":49},"CONTACT","0032 2 764 85 19","frank.aboubakar@saintluc.uclouvain.be",{"name":51,"role":47,"phone":52,"phoneExt":39,"email":53},"Kim Henquin, Study nurse","0032 2 764 42 26","kim.henquin@saintluc.uclouvain.be",[55],{"facility":56,"status":57,"city":58,"state":39,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Cliniques universitaires saint Luc","RECRUITING","Brussels","1200","Belgium","BE",{"type":63,"coordinates":64},"Point",[65,66],4.34878,50.85045,{"lat":66,"lon":65},[69,71,72,74,77],{"name":42,"role":47,"phone":48,"phoneExt":39,"email":70},"frank.aboubaka@saintluc.uclouvain.be",{"name":51,"role":47,"phone":52,"phoneExt":39,"email":53},{"name":42,"role":73,"phone":39,"phoneExt":39,"email":39},"PRINCIPAL_INVESTIGATOR",{"name":75,"role":76,"phone":39,"phoneExt":39,"email":39},"Valerie Lacroix, MD; PhD","SUB_INVESTIGATOR",{"name":78,"role":76,"phone":39,"phoneExt":39,"email":39},"Delphine Hoton, MD",{"type":80,"investigatorFullName":39,"investigatorTitle":39,"investigatorAffiliation":39,"oldNameTitle":39,"oldOrganization":39},"SPONSOR","100622536","immune-cells-role-in-lung-cancer-and-their-use-in-anticancer-immunotherapies-and-inflammatory-lung-disease-100622536",false,"NCT07384897","Immune Cells Role in Lung Cancer and Their Use in Anticancer Immunotherapies and Inflammatory Lung Disease","IMMUNOPUMON2","Inclusion Criteria:\n\n* Diagnosis of lung cancer\n* Presence of precancerous lung lesions\n* Patients with a chronic inflammatory lung disease (sarcoidosis or chronic obstructive pulmonary disease \\[COPD\\]) prior to any treatment\n* Control group: individuals without known lung disease\n* Children and adolescents weighing ≥ 10 kg with genetically confirmed chronic granulomatous disease (CGD)\n* Adults scheduled to undergo orthopedic surgery during which a bone marrow sample will be collected\n\nExclusion Criteria:\n\n* Systemic corticosteroid therapy \\> 10 mg\u002Fday prednisone (or equivalent)\n* Acute infection at the time of inclusion\n* Refusal or inability to provide informed consent (or assent, when applicable)\n* Chronic inflammatory lung disease currently treated with immunosuppressive therapy",true,"ALL","80 Years",{"count":92,"type":93},425,"ESTIMATED","INTERVENTIONAL",[96],"NA","This study aims to better understand the role of immune system cells in lung diseases such as lung cancer, sarcoidosis, and chronic obstructive pulmonary disease (COPD).\n\nThe investigators are studying how these immune cells can sometimes help the body defend itself, but in other cases may contribute to cancer growth or long-term lung inflammation.\n\nAlthough recent treatments like immunotherapy have improved cancer care, only a small proportion of patients currently benefit from these therapies. One goal of this research is to understand why some patients do not respond or develop resistance to treatment.\n\nThe knowledge gained from this study may help researchers develop more effective and personalized treatments for people with lung diseases in the future.",[99,100,101,102,103],"Lung Cancer (Diagnosis)","Sarcoidosis","Chronic Obstructive Pulmonary Disease","Immunotherapy Resistance","Immune Dysregulation",[105,106,100,101,107,108,109,103,110,102,111,112,113,114,115,116,117,118],"lung cancer","Non-Small Cell Lung Cancer","COPD","Immune Cells","Tumor Microenvironment","Immunotherapy","Immune Profiling","Myeloid Cells","Neutrophils","Dendritic Cells","Inflammation","Chronic Inflammation","Immune suppression","Emergency myelopoiesis","2026-01-26",{"date":121,"type":122},"2026-02-03","ACTUAL",{"date":124,"type":122},"2025-02-17",{"date":126,"type":93},"2032-02-17",{"name":5,"class":6},1]