[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560776":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":12,"centralContacts":17,"locations":26,"responsibleParty":149,"collaborators":7,"id":151,"slug":152,"hasResults":153,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":153,"sex":159,"minAge":160,"maxAge":7,"enrollmentInfo":161,"targetDuration":7,"studyType":164,"phases":7,"briefSummary":165,"conditions":166,"keywords":170,"overallStatus":29,"whyStopped":7,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":186},{"fullName":5,"class":6},"Istituto Oncologico Veneto IRCCS","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"Translation analysis","Bulk GEP analysis, Spatial whole transcriptome analysis, mIF analysis of tumors",[13],{"name":14,"affiliation":15,"role":16},"Giulia Pasello, MD","Istituto Oncologico Veneto IOV IRCCS","PRINCIPAL_INVESTIGATOR",[18,22],{"name":14,"role":19,"phone":20,"phoneExt":7,"email":21},"CONTACT","0498215608","giulia.pasello@iov.veneto.it",{"name":23,"role":19,"phone":24,"phoneExt":7,"email":25},"Gian Luca De Salvo, MD","0498215704","clinical.trial@iov.veneto.it",[27,44,57,69,81,93,105,114,125,137],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Istituto Clinico Humanitas","RECRUITING","Rozzano","Milano","20089","Italy","IT",{"type":36,"coordinates":37},"Point",[38,39],9.1559,45.38193,{"lat":39,"lon":38},[42],{"name":43,"role":19,"phone":7,"phoneExt":7,"email":7},"Paolo Andrea Zucali, Prof",{"facility":45,"status":29,"city":46,"state":47,"zip":48,"country":33,"countryCode":34,"cosmosGeoPoint":49,"geoPoint":53,"contacts":54},"Centro di Riferimento Oncologico (CRO) IRCCS","Aviano","Pordenone","33081",{"type":36,"coordinates":50},[51,52],12.59472,46.07056,{"lat":52,"lon":51},[55],{"name":56,"role":19,"phone":7,"phoneExt":7,"email":7},"Alessandro Del Conte, MD",{"facility":58,"status":29,"city":59,"state":7,"zip":60,"country":33,"countryCode":34,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo","Alessandria","15121",{"type":36,"coordinates":62},[63,64],8.61007,44.90924,{"lat":64,"lon":63},[67],{"name":68,"role":19,"phone":7,"phoneExt":7,"email":7},"Federica Grosso, MD",{"facility":70,"status":29,"city":71,"state":7,"zip":7,"country":33,"countryCode":34,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Asst Papa Giovanni Xxiii Bergamo","Bergamo",{"type":36,"coordinates":73},[74,75],9.66721,45.69601,{"lat":75,"lon":74},[78],{"name":79,"role":19,"phone":7,"phoneExt":7,"email":80},"Anna Cecilia Bettini, MD","abettini@asst-pg23.it",{"facility":82,"status":29,"city":83,"state":7,"zip":7,"country":33,"countryCode":34,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Ircss Ospedale Policlinico San Martino","Genova",{"type":36,"coordinates":85},[86,87],11.87211,45.21604,{"lat":87,"lon":86},[90],{"name":91,"role":19,"phone":7,"phoneExt":7,"email":92},"Chiara Dellepiane, MD","chiara.dellepiane@hsanmartino.it",{"facility":94,"status":29,"city":95,"state":7,"zip":7,"country":33,"countryCode":34,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Asst Grande Ospedale Metropolitano Niguarda-Milano","Milan",{"type":36,"coordinates":97},[98,99],12.59836,42.78235,{"lat":99,"lon":98},[102],{"name":103,"role":19,"phone":7,"phoneExt":7,"email":104},"Diego Signorelli, MD","diego.signorelli@ospedaleniguarda.it",{"facility":106,"status":29,"city":95,"state":7,"zip":7,"country":33,"countryCode":34,"cosmosGeoPoint":107,"geoPoint":109,"contacts":110},"Fondazione Ircss Istituto Nazionale Dei Tumori Di Milano",{"type":36,"coordinates":108},[98,99],{"lat":99,"lon":98},[111],{"name":112,"role":19,"phone":7,"phoneExt":7,"email":113},"Mario Occhipinti, MD","mario.occhipinti@istitutotumori.mi.it",{"facility":115,"status":29,"city":116,"state":7,"zip":117,"country":33,"countryCode":34,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Istituto Oncologico Veneto","Padova","35128",{"type":36,"coordinates":119},[120,121],11.14261,44.38225,{"lat":121,"lon":120},[124],{"name":14,"role":19,"phone":20,"phoneExt":7,"email":21},{"facility":126,"status":29,"city":127,"state":7,"zip":128,"country":33,"countryCode":34,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"Azienda Ospedaliera-Universitaria di Parma","Parma","43126",{"type":36,"coordinates":130},[131,132],10.32618,44.79935,{"lat":132,"lon":131},[135],{"name":136,"role":19,"phone":7,"phoneExt":7,"email":7},"Marcello Tiseo, Prof",{"facility":138,"status":29,"city":139,"state":7,"zip":7,"country":33,"countryCode":34,"cosmosGeoPoint":140,"geoPoint":144,"contacts":145},"Azienda Ospedaliera Universitaria Integrata Verona","Verona",{"type":36,"coordinates":141},[142,143],10.9938,45.43854,{"lat":143,"lon":142},[146],{"name":147,"role":19,"phone":7,"phoneExt":7,"email":148},"Jessica Menis, MD","jessica.menis@aovr.veneto.it",{"type":150,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100560776","immune-microenvironment-and-gene-expression-profiling-in-mesothelioma-100560776",false,"NCT06581549","Immune Microenvironment and Gene Expression Profiling in Mesothelioma","From Immune Microenvironment Characterization and Gene Expression Profiling to New Drugs Testing in Pleural and Peritoneal Mesothelioma: Imaging-Meso Study","Imaging-Meso","Inclusion Criteria:\n\n* Patients with Mesothelioma of the Pleura and Peritoneum\n* Age greater than 18 years of age\n* Patients undergoing surgery will require both biopsy and surgical sampling material\n* Pathologist's confirmation of the presence of tumor sections in the excised specimens\n* Patients in follow-up from active cancer treatment for at least 6 months\n\nExclusion Criteria:\n\n* Inadequacy of biological material for analysis under study\n* Patients not amenable to active oncologic treatment\n* Patients lost to follow-up before 6 months after the end of active oncologic treatment","ALL","18 Years",{"count":162,"type":163},220,"ESTIMATED","OBSERVATIONAL","Pleural and peritoneal mesotheliomas (PPM) are rare cancers mostly related to asbestos-exposure, which are characterized by a complex histopathological diagnosis and staging, few therapeutic options and a dismal prognosis. The main unmet medical need in PPM is the lack of a treatment sequence for affected patients. The advent of immune checkpoint inhibitors has changed the first line treatment of PPM, thanks to the improvement in survival achieved by the combination of ipilimumab and nivolumab that are currently approved for non-epithelioid histology in our Country.\n\nPPM is characterized by a large heterogeneity of the genomic landscape, which is mainly characterized by the loss of tumour suppressor genes and mutations in DNA repair genes and by an \"altered- suppressed\" or \"excluded\" tumor immune microenvironment (TIME).\n\nThe goal of this project is to improve the immune-biological and molecular stratification of PPM subgroups that can lead to the identification of different personalized treatment approaches. PPM patients (N=220) will be retrospectively (N=150) and prospectively (N=70) recruited from the coordinator center and 6 participating Italian centers. Treatment-naïve tumor samples will be collected and analyzed by bulk gene expression and spatial whole transcriptome analysis, and by 9-color multiplex immunofluorescence.\n\nNew targets or actionable pathways potentially emerging from such studies will be finally assessed and validated in patient-derived organoids\u002Fxenografts that accurately reflect PPM tumorigenesis.",[167,168,169],"Mesothelioma","Mesotheliomas Pleural","Mesothelioma; Lung",[171,172,173,174,175,176],"pleura","mesothelioma","PPM patients","lung","Gene expression profiling","Immune microenvironment","2025-09-04",{"date":179,"type":180},"2025-09-05","ACTUAL",{"date":182,"type":180},"2023-11-02",{"date":184,"type":163},"2026-12-31",{"name":5,"class":6},10]