[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630896":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":27,"locations":33,"responsibleParty":51,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":10,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":76,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"First Affiliated Hospital of Ningbo University","NETWORK",[8,12,15,18,21,24],{"label":9,"type":10,"description":11,"interventionNames":10},"COPD group",null,"The clinical diagnosis was COPD",{"label":13,"type":10,"description":14,"interventionNames":10},"Bronchiectasis group","The clinical diagnosis was Bronchiectasis",{"label":16,"type":10,"description":17,"interventionNames":10},"OSAS group","The clinical diagnosis was OSAS",{"label":19,"type":10,"description":20,"interventionNames":10},"Asthma group","The clinical diagnosis was asthma",{"label":22,"type":10,"description":23,"interventionNames":10},"ABPA group","The clinical diagnosis was ABPA",{"label":25,"type":10,"description":26,"interventionNames":10},"Health comparison","Healthy person without respiratory disease",[28],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"chao Cao, Doctor","CONTACT","+86-0574-87085233","caocdoctor@163.com",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":10,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"The First Affiliated Hospital of Ningbo University","RECRUITING","Ningbo","Zhejiang","China","CN",{"type":42,"coordinates":43},"Point",[44,45],121.54945,29.87819,{"lat":45,"lon":44},[48],{"name":29,"role":30,"phone":49,"phoneExt":10,"email":50},"+86-0574-87089878","caodoctor@163.com",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100630896","immune-status-and-disease-control-of-inflammatory-airway-diseases-100630896",false,"NCT07493629","Immune Status and Disease Control of Inflammatory Airway Diseases","Association Between Immune Status and Disease Control in Patients With Inflammatory Airway Diseases","ISDC-IAD","Inclusion Criteria\n\n1. Age ≥18 years (≥40 years for COPD patients).\n2. Clinical diagnosis of asthma, ABPA, bronchiectasis, OSAS, or COPD according to established criteria.\n3. PRISm patients (post-BD FEV1\u002FFVC ≥70% and FEV1 \\\u003C80% predicted)\n4. Smoking controls: ≥10 pack-years, normal lung function, no chronic respiratory symptoms.\n5. Healthy controls: normal lung function, FeNO \\\u003C20 ppb, total IgE \\\u003C100 IU\u002FmL, no chronic disease, smoking \\\u003C10 pack-years, no immunosuppressant use within 3 months.\n\nExclusion Criteria\n\n1. Patients with severe respiratory diseases other than those included in the study, such as pulmonary embolism, pneumothorax, pulmonary hypertension, interstitial lung disease, or active lung cancer.\n2. Patients with severe systemic diseases that may interfere with study completion, such as myocardial infarction, severe arrhythmia, hepatic insufficiency, renal insufficiency, hematological disorders, or malignancy.\n3. Patients with an acute exacerbation within 4 weeks before enrollment, or systemic use of antibiotics, antifungal drugs, immunosuppressive agents, cytotoxic agents, or corticosteroids (except for long-term maintenance therapy)\n4. Pregnant or lactating women.\n5. Patients with poor compliance as judged by the investigators.\n6. Subjects currently participating in other clinical studies.",true,"ALL","18 Years",{"count":65,"type":66},200,"ESTIMATED","OBSERVATIONAL","The goal of this study is to learn how the body's immune system affects disease control in people with different airway inflammatory diseases.We want to understand:\n\n1.Whether specific immune cell patterns in the blood are linked to how severe the disease is or how well it is controlled.\n\nParticipants will:\n\n1. Answer questions about their health and symptoms.\n2. Give blood samples\n3. Have lung function tests and other standard check-ups.\n4. share sleep study results. We will compare people with airway diseases to healthy volunteers to see how their immune systems differ.",[70,71,72,73,74,75],"Airway Inflammation","Chronic Obstructive Pulmonary Disease (COPD)","Asthma (Diagnosis)","Bronchiectasis","OSAS (Obstructive Sleep Apneas Syndrome)","Allergic Bronchopulmonary Aspergillosis (ABPA)",[77,78,79,80,81],"Airway Inflammatory Diseases","Immunophenotyping","Metabolomics","Cytometry by Time-of-Flight","High-dimensional immune profiling","2026-03-23",{"date":84,"type":85},"2026-03-25","ACTUAL",{"date":87,"type":85},"2025-08-01",{"date":89,"type":66},"2026-08-01",{"name":5,"class":6},1]