[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566545":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":27,"centralContacts":31,"locations":21,"responsibleParty":41,"collaborators":44,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":21,"eligibilityCriteria":52,"healthyVolunteers":49,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":21,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":68,"whyStopped":21,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":21},{"fullName":5,"class":6},"Rady Pediatric Genomics & Systems Medicine Institute","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Enrollees - WGS","EXPERIMENTAL","These participants will be subject to whole genome sequencing and Phage ImmunoPrecipiation sequencing (PhIP-Seq) to identify genetic changes and novel antibodies associated with catatonia.",[13,14],"Genetic: Genetic: Genomic sequencing and molecular diagnostic results, if any.","Diagnostic Test: Phage display ImmunoPrecipiation Sequencing (PhIP-Seq)",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"GENETIC","Genetic: Genomic sequencing and molecular diagnostic results, if any.","Genomic sequencing results may be used for diagnosis and treatment of participants.",[9],null,{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":21},"DIAGNOSTIC_TEST","Phage display ImmunoPrecipiation Sequencing (PhIP-Seq)","Whole Proteome programmable phage display immunoprecipitation sequencing will be used to diagnose known and novel autoantibodies.",[9],[28],{"name":29,"affiliation":5,"role":30},"Aaron Besterman, MD","PRINCIPAL_INVESTIGATOR",[32,37],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":36},"CONTACT","858-576-1700","221633","abesterman@health.ucsd.edu",{"name":38,"role":33,"phone":34,"phoneExt":39,"email":40},"Corrine Blucher, BS","221632","cblucher@rchsd.org",{"type":30,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"Aaron Besterman","Health Sciences Associate Clinical Professor, UCSD Department of Psychiatry Clinical Investigator, Rady Children's Institute for Genomic Medicine Child & Adolescent Psychiatrist, Rady Children's Hospital San Diego",[45],{"name":46,"class":6},"Brain & Behavior Research Foundation","100566545","immunogenomic-analyses-of-pediatric-catatonia-100566545",false,"NCT06656572","Immunogenomic Analyses of Pediatric Catatonia","Inclusion Criteria:\n\n* Individual in whom one of the following criteria is met:\n\n  1. Child\u002Fadolescent Ages 0-17 (2) with a diagnosis of catatonia.\n\n     OR\n  2. Biological parents of child\u002Fadolescent enrolled in this study for the purposes of reflex testing. Family members are eligible for participation in this study if they are presumed to be genetically related to a patient participant\n\nExclusion Criteria:\n\n* Child\u002Fadolescents patients who do not meet any of the inclusion criteria, or those who:\n\n  1. Already received any prior whole genome sequencing or exome sequencing.\n  2. Unable to approach the family or patient for enrollment.\n  3. Unable to obtain informed consent.\n  4. Family members are ineligible for participation in this study if:\n\n     1. They are known to not be genetically related to the child\u002Fadolescent patient participant","ALL","0 Years","17 Years",{"count":57,"type":58},120,"ESTIMATED","INTERVENTIONAL",[61],"NA","Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 40 children and adolescents who are admitted to Rady Children's Hospital San Diego with a catatonia diagnosis. Cutting-edge genome and protein sequencing technology will be used to better understand how immunological and genetic assessments may improve the ability to identify the cause of catatonia and impact care. The investigator also hopes to identify new genetic and\u002For autoimmune causes of catatonia that may inform new treatment for future patients.",[64],"Catatonia",[66,67],"Genomics","Pediatric","NOT_YET_RECRUITING","2024-11-12",{"date":71,"type":72},"2024-11-14","ACTUAL",{"date":74,"type":58},"2024-12-01",{"date":76,"type":58},"2030-09-01",{"name":5,"class":6}]