[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100466749":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":25,"centralContacts":30,"locations":35,"responsibleParty":52,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"MS patients with IgG deficiency (serum IgG-concentration \u003C7g\u002FL).",null,"MS patients with IgG deficiency (serum IgG-concentration \\\u003C7g\u002FL).",[13],"Diagnostic Test: Laboratory test",{"label":15,"type":10,"description":15,"interventionNames":16},"MS patients with normal IgG serum concentration (serum IgG-concentration ≥7g\u002FL).",[13],[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"DIAGNOSTIC_TEST","Laboratory test","Frequency of fatigue (defined as Fatigue Scala for Motor and Cognitive Function (FSMC) total ≥ 43 points) in MS patients with IgG-deficiency",[9,15],[24],"Fatigue Score",[26],{"name":27,"affiliation":28,"role":29},"Lara Diem, MD","Inselspital University Hospital of Bern","PRINCIPAL_INVESTIGATOR",[31],{"name":27,"role":32,"phone":33,"phoneExt":10,"email":34},"CONTACT","0041316327000","larafrancesca.diem@insel.ch",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"University Hospital of Bern Inselspital","RECRUITING","Bern","Canton of Bern","3010","Switzerland","CH",{"type":45,"coordinates":46},"Point",[47,48],7.44744,46.94809,{"lat":48,"lon":47},[51],{"name":27,"role":32,"phone":33,"phoneExt":10,"email":34},{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100466749","immunoglobulin-deficiency-a-treatable-cause-of-fatigue-in-patients-with-multiple-sclerosis-ms-100466749",false,"NCT05357781","Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)?","Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)? - A Prospective Observational Fatigue Trial","FatIgG","Inclusion Criteria:\n\n* Diagnosis of Multiple Sclerosis following McDonald 2017-Criteria\n* Age 18-65 years\n* Stable MS disease at inclusion (definition: no clinical relapse, no MRI activity, stable disability within the last 12 months)\n* Unchanged immunotherapy within the last 12 months\n* Expanded Disability Status Scale (EDSS) level \\\u003C4 points indicating fully ambulatory patients.\n* Capability of written informed consent\n\nExclusion Criteria:\n\n* Severe depression (definition: Beck Depression Index-II (BDI-II) ≥29 points) or other established psychiatric diagnosis\n* Immunodeficiency other than hypogammaglobulinemia\n* Immunglobulin replacement therapy or indication for immunoglobulin replacement therapy\n* Severe Sleepiness (definition: Epworth-Sleepiness-Scale (ESS) \\>16 points)\n* Fatigue aggravating factors such: liver\u002Frenal\u002Fthyroid dysfunction, substance abuse, medication (tranquilizers \u002Fantiepileptics\u002Fpsychopharmaceuticals), chronic infectious disease (like hepatitis\u002FHIV).\n* Other neurodegenerative\u002Fautoimmune disease.\n* Patients not able to give written consent\n* Vulnerable patients such as children, pregnant women and prisoners","ALL","18 Years","65 Years",{"count":66,"type":67},106,"ESTIMATED","OBSERVATIONAL","The investigators hypothesize that hypogammaglobulinemia (defined as IgG serum concentration \\\u003C7.0g\u002FL) is a treatable cause of fatigue in people with MS:\n\nThe primary objective is to prove the link between hypogammaglobulinemia and fatigue in patients with multiple sclerosis.\n\nThe secondary objective is to show that fatigue is mediated via frequent infections in people with MS and hypogammaglobulinemia.",[71,72,73],"Hypogammaglobulinemia","Multiple Sclerosis","Fatigue",[73,71],"2026-04-30",{"date":77,"type":78},"2026-05-01","ACTUAL",{"date":80,"type":78},"2022-07-01",{"date":82,"type":67},"2026-12-30",{"name":5,"class":6},1]