[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588781":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":21,"locations":31,"responsibleParty":50,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":10,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"University Hospital, Rouen","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Group 1: patients in the acute phase of TTP",null,"Consultation or hospitalisation when TTP is diagnosed, before treatment is initiated",{"label":13,"type":10,"description":14,"interventionNames":10},"Groupe 2 : patient in durable remission with ADAMTS13 activity > 10%.","Follow-up consultation",{"label":16,"type":10,"description":17,"interventionNames":10},"Groupe 3 : patient in remission with ADAMTS13 activity \u003C 10%.","Follow-up consultation before initiation of pre-emptive treatment",{"label":19,"type":10,"description":20,"interventionNames":10},"Group 4: relapsing patients","Consultation or hospitalisation at the time of relapse, before treatment is initiated",[22,28],{"name":23,"role":24,"phone":25,"phoneExt":26,"email":27},"David DM MALLET, Director","CONTACT","02 32 88 82 65","+33","david.mallet@chu-rouen.fr",{"name":29,"role":24,"phone":25,"phoneExt":26,"email":30},"Vincent VF FERRANTI, ARC","vincent.ferranti@chu-rouen.fr",[32],{"facility":33,"status":34,"city":35,"state":10,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"University Rouen Hospital,","RECRUITING","Rouen","76031","France","FR",{"type":40,"coordinates":41},"Point",[42,43],1.09932,49.44313,{"lat":43,"lon":42},[46],{"name":47,"role":24,"phone":48,"phoneExt":26,"email":49},"Mathilde ML LECLERCQ, Doctor","02 32 88 73 96","Mathilde.Leclercq@chu-rouen.fr",{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100588781","immunological-aspect-of-thrombotic-thrombocytopenic-purpura-ttp-100588781",false,"NCT06945861","Immunological Aspect of Thrombotic Thrombocytopenic Purpura (TTP)","Immunological Aspects of Thrombotic Thrombocytopenic Purpura (TTP): Characterisation of B and T Lymphocytes Specific for the ADAMTS13 Autoantigen and Therapeutic Implications","Lympho-PTT","Inclusion Criteria:\n\n* age over 18\n* patients with TTP at any stage of diagnosis (acute phase, lasting remission or not, relapse)\n* patients undergoing internal medicine at Rouen University Hospital\n* people who have read and understood the information letter\n* membership of a social security scheme\n\nExclusion Criteria:\n\n\\- a person deprived of liberty by an administrative or judicial decision or a person placed under court protection\u002Fguardianship or guardianship","ALL","18 Years",{"count":63,"type":64},44,"ESTIMATED","OBSERVATIONAL","The general objective of the proposed project is to characterise phenotypically and functionally ADAMTS13-specific memory B lymphocytes and autoreactive T lymphocytes, in particular follicular helper T lymphocytes, in the acute phase of the disease, but also during its progression after treatment. The aim is to highlight their contribution to the initial pathogenic process, their evolution under treatment, and also their involvement in patients who are refractory to immunosuppressive therapies and during relapses. The aim of this project is to identify early phenotypic or functional parameters that are predictive of relapse and that can be used for personalised optimisation of treatment to maintain remission.",[68],"Thrombotic Thrombocytopenic Purpura (TTP)","2026-04-28",{"date":71,"type":72},"2026-05-04","ACTUAL",{"date":74,"type":72},"2023-05-11",{"date":76,"type":64},"2028-05-11",{"name":5,"class":6},1]