[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100409725":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":31,"locations":41,"responsibleParty":57,"collaborators":26,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":26,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":26,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Hopital Foch","OTHER",[8,13,17],{"label":9,"type":6,"description":10,"interventionNames":11},"Graft recipient","During each of the visits carried out with a cervical biopsy as part of the uterine transplant project, samples will be taken.",[12],"Other: Specimens",{"label":14,"type":6,"description":15,"interventionNames":16},"Living donor","The donors will benefit from a blood sample and a sample of the vaginal microbiota during the transplant under general anesthesia or after it during a consultation scheduled as part of the uterine transplant protocol.",[12],{"label":18,"type":6,"description":19,"interventionNames":20},"Witness","10 non-menopausal control patients will each have a cervical biopsy (at different times of the cycle) and a smear, samples of the vaginal microbiota and a blood sample. Among the 10 controls, 4 patients will have to undergo a hysterectomy for which multiple staged biopsies and samples uterine microbiota will be produced.",[12],[22],{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"Specimens","Specimens (blood, biopsy, cervical smear, vaginal swab)",[9,14,18],null,[28],{"name":29,"affiliation":5,"role":30},"Jean-Marc Ayoubi, MD, PhD","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Marie Carbonnel, MD","CONTACT","+331 46 25 48 53","m.carbonnel@hopital-foch.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Elisabeth Hulier-Ammar","+331 46 25 11 75","drci-promotion@hopital-foch.com",[42],{"facility":5,"status":43,"city":44,"state":26,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Suresnes","92151","France","FR",{"type":49,"coordinates":50},"Point",[51,52],2.22929,48.87143,{"lat":52,"lon":51},[55],{"name":56,"role":34,"phone":26,"phoneExt":26,"email":36},"Marie Carbonnel",{"type":58,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100409725","immunological-mechanisms-of-rejection-in-uterine-transplantation-100409725",false,"NCT04615221","Immunological Mechanisms of Rejection in Uterine Transplantation","MARNI","Inclusion Criteria:\n\n* Patient going to or having received a uterine transplant OR Patient going to or having donated a uterus for a recipient included in the study OR Premenopausal woman to undergo gynecological surgery under general anesthesia: for 4 of them it was a hysterectomy and they must be under 45 years old, the other 6 must be under 38 years old.\n\nExclusion Criteria (For witness):\n\n* Pregnancy in progress\n* Current infection\n* Cervical dysplasia\n* History of transplant or transfusion\n* Cancer or history of cancer\n* Menopause\n* Patient aged 38 or over for the 6 controls without hysterectomy, patient aged 45 or over for the 4 patients with hysterectomy.\n* Endometriosis","FEMALE","18 Years","45 Years",{"count":70,"type":71},30,"ESTIMATED","INTERVENTIONAL",[74],"NA","The objective of this study is to understand the mechanisms of rejection in uterine transplantation and to search for non-invasive markers of rejection. The biological samples necessary for our research have been or will be collected during procedures (biopsies, smears, vaginal swab, blood tests) carried out as part of the scheduled follow-up of patients. These will be samples whose collection is minimally or not invasive",[77],"Transplant Rejection","2025-09-08",{"date":80,"type":81},"2025-09-12","ACTUAL",{"date":83,"type":81},"2020-09-21",{"date":85,"type":71},"2033-09",{"name":5,"class":6},1]