[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620566":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":24,"locations":34,"responsibleParty":53,"collaborators":12,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":12,"maxAge":12,"enrollmentInfo":64,"targetDuration":12,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":83,"overallStatus":37,"whyStopped":12,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University Hospital, Caen","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","NO_INTERVENTION","The primary care practices in the control group do not receive any intervention and continue patient management according to their usual practices.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Intervention group","EXPERIMENTAL","For the intervention group, two planned interventions will be planed and applied to the primary care practices:\n\n1. Use of the OPIV (Viral Infection Prescription Tool).\n2. A multidisciplinary collaboration protocol between general practitioners and pharmacists to evaluate antibiotic treatment durations. This intervention aims to strengthen collaborative practices. If a prescribed duration does not comply with recommendations, the pharmacist will discuss it with the prescriber, and the duration will be adjusted accordingly.\"",[18],"Other: Antibiotic prescribing according to guidelines",[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":12},"Antibiotic prescribing according to guidelines","If necessary, the general practitioner prescribes antibiotics to patients consulting for an upper or lower respiratory tract infection, according to the guidelines.",[14],[25,30],{"name":26,"role":27,"phone":28,"phoneExt":12,"email":29},"Renaud Verdon, PU-PH","CONTACT","+33231064709","verdon-r@chu-caen.fr",{"name":31,"role":27,"phone":32,"phoneExt":12,"email":33},"Pascal Thibon, PH","+33231065150","thibon-p@chu-caen.fr",[35],{"facility":36,"status":37,"city":38,"state":12,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"CHU CAEN Normandie","RECRUITING","Caen","14000","France","FR",{"type":43,"coordinates":44},"Point",[45,46],-0.35912,49.18585,{"lat":46,"lon":45},[49],{"name":50,"role":27,"phone":51,"phoneExt":12,"email":52},"François FOURNEL, head of project","+33231065488","fournel-f@chu-caen.fr",{"type":54,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100620566","impact-of-a-multimodal-intervention-on-antibiotic-prescribing-for-respiratory-infections-in-primary-care-100620566",false,"NCT07359287","Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care","Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care: A Cluster-Randomized Trial","GRASP","Inclusion Criteria:\n\n\\- Patient seen in consultation for an upper or lower respiratory tract infection (Angina, Acute bronchiolitis, Acute bronchitis, COPD exacerbation (AECOPD), Laryngitis, Acute otitis media (AOM), Serous or congestive otitis, Viral respiratory infection (e.g., influenza), Community-acquired pneumonia (CAP), Rhinitis \u002F Nasopharyngitis, Acute sinusitis)\n\nExclusion Criteria:\n\n\\- Patient under legal protection","ALL",{"count":65,"type":66},4500,"ESTIMATED","INTERVENTIONAL",[69],"NA","Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France are prescribed and where misuse remains common.\n\nWe are proposing a cluster-randomized controlled trial to evaluate the effectiveness of a bimodal intervention combining: (1) improved communication about the circulation of respiratory viruses, and (2) strengthened collaborative practices between general practitioners and pharmacists through a multidisciplinary protocol aimed at verifying that prescribed treatment durations comply with guidelines.\n\nThe study will include six primary care practices (24 physicians), with three practices in each study arm.\n\nThe aim of this project is to assess whether the bimodal intervention can reduce the duration of antibiotic treatments for upper and lower respiratory tract infections. The first component (a \"viral infection prescription\" tool) focuses on reducing unnecessary treatment initiation, while the second (pharmacist-led review) aims to shorten excessive prescription durations.",[72,73,74,75,76,77,78,79,80,81,82],"Angina","Acute Bronchiolitis","Acute Bronchitis","COPD Exacerbation (AECOPD)","Laryngitis","Acute Otitis Media (AOM)","Serous or Congestive Otitis","Viral Respiratory Infection (e.g., Influenza)","Community-Acquired Pneumonia (CAP)","Rhinitis \u002F Nasopharyngitis","Acute Sinusitis",[84,85],"Upper respiratory tract infection","Lower respiratory tract infection","2026-01-13",{"date":88,"type":89},"2026-01-22","ACTUAL",{"date":91,"type":89},"2025-12-01",{"date":93,"type":66},"2026-09-01",{"name":5,"class":6},1]