[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603022":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":27,"centralContacts":32,"locations":42,"responsibleParty":58,"collaborators":10,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":10,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":10,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":10,"overallStatus":85,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":10,"interventionNames":11},"COA patients",null,[12,13],"Radiation: CT aortography","Radiation: CMR",{"label":15,"type":10,"description":10,"interventionNames":16},"Healthy controls",[12],[18,23],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"RADIATION","CT aortography","Performed before and after stenting using a multidetector CT scanner (device model and parameters to be specified).\n\nAnalysis will include:\n\n* Evaluation of aortic arch geometry (normal \u002F gothic \u002F crenel).\n* Measurement of residual stenosis at the site of coarctation.\n* Aortic diameter measurements at predefined anatomical levels:\n\nAscending aorta (AA), Proximal descending thoracic aorta (PDA), At the level of the diaphragm (DA), Abdominal aorta (AbAo).\n\n\\- Aortic tortuosity. All CT data will be interpreted by two independent observers blinded to clinical outcomes",[9,15],{"type":19,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"CMR","CMR examinations will be performed using a commercially available 1.5 Tesla whole-body scanner (Ingenia, Philips Healthcare, release 4.1.3.0). In pediatric or uncooperative patients, free-breathing sequences were used when breath-holding was not feasible.\n\nBrachial blood pressure was measured in the right arm in the supine position immediately before image acquisition using automated oscillometric devices.\n\nCine steady-state free precession (SSFP) sequences were obtained in multiple views including the short axis of the ascending aorta (AAO) and descending aorta (DAO), as well as the aortic root to evaluate aortic valve morphology (bicuspid vs tricuspid).\n\nLeft ventricular (LV) and left atrial (LA) functional parameters were assessed by standard volumetric analysis. The following CMR-derived parameters were collected:\n\nLeft ventricular ejection fraction (LVEF) Left ventricular strain Left ventricular mass index (LVMI) Left atrial volume Left atrial strain LV and LA strain were analyzed usi",[9],[28],{"name":29,"affiliation":30,"role":31},"Salwa Demitry Roshdy, Professor","Faculty of medicine AssiutU university","STUDY_DIRECTOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":10,"email":37},"Mena Wadee, Resident doctor","CONTACT","01282210873","menawade399@gmail.com",{"name":39,"role":35,"phone":40,"phoneExt":10,"email":41},"Noha Gamal","+201002295166","noha_cardio@aun.edu.eg",[43],{"facility":44,"status":10,"city":45,"state":10,"zip":10,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Institutional Review Board (IRB) of Faculty of Medicine","Asyut","Egypt","EG",{"type":49,"coordinates":50},"Point",[51,52],31.18368,27.18096,{"lat":52,"lon":51},[55],{"name":5,"role":35,"phone":56,"phoneExt":10,"email":57},"+2088 22080150","irbasyut@aun.edu.eg",{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Mina wadee fathy","Principal investigator","100603022","impact-of-aortic-geometry-on-vascular-remodeling-after-stent-implantation-in-coarctation-of-the-aorta-100603022",false,"NCT07131111","Impact of Aortic Geometry on Vascular Remodeling After Stent Implantation in Coarctation of the Aorta","Inclusion Criteria:\n\nAge ≥ 12 years.\n\nDiagnosed with native or recurrent coarctation of the aorta.\n\nTranscatheter systolic pressure gradient ≥ 20 mmHg.\n\nBody weight ≥ 20 kg.\n\nAvailability of pre- and post-stenting CT aortography data.\n\nExclusion Criteria:\n\nPatients with obstructive lesion of LVOT or aortic valve dysfunction greater than moderate (requiring surgical intervention)..\n\nPatients with other causes of secondary hypertension.\n\nAssociated complex congenital heart defects (aside from simple septal defects and patent ductus arteriosus)\n\nGenetic syndromes\n\nConnective tissue disorder\n\nHistory of surgery involving the aortic root or ascending aorta.\n\nIncomplete imaging or missing data relevant to the study.",true,"ALL","12 Years",{"count":72,"type":73},50,"ESTIMATED","OBSERVATIONAL","This study aims to assess:\n\n1. Aortic geometrical changes and their relationship to hypertension and cardiovascular events.\n2. Aortic geometrical differences between healthy individuals and patients with repaired coarctation of the aorta.",[77,78,79,80,81,82,24,83,84],"Aortic Geometry","Vascular Remodeling","Coarctation of Aorta","Blood Pressure","Residual Stenosis","CT Aortography","Aortic Elasticity and Distensibility","Aortic Arch","NOT_YET_RECRUITING","2025-08-12",{"date":88,"type":89},"2025-08-20","ACTUAL",{"date":91,"type":73},"2025-09-01",{"date":93,"type":73},"2026-12-31",{"name":5,"class":6},1]