[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637594":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":31,"responsibleParty":46,"collaborators":20,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":9,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":20,"enrollmentInfo":57,"targetDuration":20,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":74,"whyStopped":20,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Centre Henri Becquerel","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"COCORIVO","EXPERIMENTAL","Patients with mCRPC treated with 177Lu-PSMA-617 undergoing additional SPECT\u002FCT acquisitions and body composition analysis",[13],"Radiation: 177Lu-PSMA-617 + SPECT\u002FCT dosimetry",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"RADIATION","177Lu-PSMA-617 + SPECT\u002FCT dosimetry","177Lu-PSMA-617 7400 MBq IV, 4 to 6 cycles every 6 weeks (standard of care).\n\nAdditional interventions: whole-body SPECT\u002FCT at 4-24H and\u002For 168-196H post-injection (research acquisitions) for dosimetry. Body composition analysis from SPECT\u002FCT scanner using Anthropometer3DNet. MNA questionnaire and nutritional blood tests at baseline and end of treatment.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Pierre Decazes, MD, PhD","CONTACT","+33 2 76 67 30 59","pierre.decazes@chb.unicancer.fr",{"name":28,"role":24,"phone":29,"phoneExt":20,"email":30},"Doriane Richard, PhD","+33 2 32 08 29 85","doriane.richard@chb.unicancer.fr",[32],{"facility":5,"status":20,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Rouen","Normanie","76038","France","FR",{"type":39,"coordinates":40},"Point",[41,42],1.09932,49.44313,{"lat":42,"lon":41},[45],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"type":47,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100637594","impact-of-body-composition-on-dosimetry-of-177lu-psma-radioligand-therapy-100637594",false,"NCT07587814","Impact of Body Composition on Dosimetry of 177Lu-PSMA Radioligand Therapy","Impact de la Composition Corporelle Sur la dosimétrie de la radiothérapie Interne vectorisée au 177Lu-PSMA","Inclusion Criteria:\n\n* Signed informed consent\n* Male, age \\>= 18 years\n* Histologically confirmed prostatic adenocarcinoma with multidisciplinary decision for 177Lu-PSMA treatment\n* PSMA expression in tumor lesions confirmed by 68Ga-PSMA PET\u002FCT\n* Affiliated to or beneficiary of a social security scheme\n\nExclusion Criteria:\n\n* Patient unable to understand the study or comply with study constraints (language barrier, psychological, geographic...)\n* Patient under legal protection (tutelle, curatelle, sauvegarde de justice)","MALE","18 Years",{"count":58,"type":59},100,"ESTIMATED","INTERVENTIONAL",[62],"NA","COCORIVO is an interventional study evaluating the impact of body composition on dosimetry of 177Lu-PSMA radioligand therapy in patients with metastatic castration-resistant prostate cancer (mCRPC). Body composition (muscle, lean, visceral fat, subcutaneous fat and total fat masses) will be automatically quantified from whole-body CT images acquired at 72-96h after 177Lu-PSMA injection using the Anthropometer3DNet software. Dosimetry will be evaluated for tumors and organs at risk (salivary glands, bone marrow, kidneys). The study also evaluates the impact of body composition on SUV quantification, the feasibility of single-timepoint dosimetry, and the evolution of body composition during treatment.",[65,66],"Carcinoma","Castration Resistant Prostatic Neoplasms",[68,69,70,71,72,73],"Lutetium-177","PSMA","Body composition","Dosimetry","Radioligand therapy","Prostate cancer","NOT_YET_RECRUITING","2026-05-11",{"date":77,"type":78},"2026-05-14","ACTUAL",{"date":80,"type":59},"2026-09",{"date":82,"type":59},"2029-06",{"name":5,"class":6},1]