[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622672":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":11,"centralContacts":11,"locations":37,"responsibleParty":55,"collaborators":11,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":11,"eligibilityCriteria":64,"healthyVolunteers":61,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":11,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":79,"overallStatus":83,"whyStopped":11,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Universidad de Almeria","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Usual-Care Control Group","PLACEBO_COMPARATOR",null,[13],"Behavioral: Usual-care control group",{"label":15,"type":16,"description":11,"interventionNames":17},"Morning Exercise Group","EXPERIMENTAL",[18],"Behavioral: Morning exercise group",{"label":20,"type":16,"description":11,"interventionNames":21},"Evening Exercise Group",[22],"Behavioral: Evening exercise group",[24,29,33],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"BEHAVIORAL","Morning exercise group","Participants perform supervised exercise sessions at 07:00h",[15],{"type":25,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"Evening exercise group","Participants perform supervised exercise sessions at 19:00h",[20],{"type":25,"name":34,"description":35,"armGroupLabels":36,"otherNames":11},"Usual-care control group","Participants receive lifestyle recommendations without exercise",[9],[38],{"facility":39,"status":11,"city":40,"state":11,"zip":11,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Universidad de Almería","Almería","Spain","ES",{"type":44,"coordinates":45},"Point",[46,47],-2.45974,36.83814,{"lat":47,"lon":46},[50],{"name":51,"role":52,"phone":53,"phoneExt":11,"email":54},"Juan M. A. Alcantara, Ph.D.","CONTACT","+34","alcantarajma@ual.es",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Juan Manuel Alcantara Alcantara","Investigador Ramón y Cajal","100622672","impact-of-circadian-exercise-on-metabolic-dysfunction-associated-steatotic-liver-disease-in-postmenopausal-women-100622672",false,"NCT07386665","Impact of Circadian Exercise on Metabolic Dysfunction-Associated Steatotic Liver Disease in Postmenopausal Women","Inclusion Criteria:\n\n* Women aged 45-75 years, postmenopausal for at least two years (stage +1a)\n* Body Mass Index (BMI) \\> 25 and \\\u003C 40 kg\u002Fm²\n* Diagnosed hepatic steatosis (via ultrasound hyperechogenicity, FibroScan CAP score \\>280, or histological confirmation)\n* Sedentary lifestyle (no regular structured exercise)\n* Willingness to be randomized and adhere to study procedures, including all assessments and visits\n* Sufficient Spanish proficiency to understand and follow study instructions\n* Consent to store biological samples for future research\n* Participants should have a healthy circadian rhythm\n\nExclusion Criteria:\n\n* Contraindications for MRI (e.g., claustrophobia, pacemaker, metal implants)\n* History of major cardiovascular, endocrine, neurological, or kidney disease, or any clinical abnormalities (to be judged by the study physician)\n* First-degree family history of sudden cardiac death\n* Alcohol or substance abuse\n* Psychiatric, psychotic, eating, or sleep disorders (to be judged by the study physician)\n* Prior bariatric surgery, diagnosed HIV\u002FAIDS, or inflammatory\u002Fautoimmune diseases\n* Cancer or any medical condition where exercise is contraindicated (to be judged by the study physician)\n* Recent or unstable metabolic conditions (e.g., diabetes, recent medication changes, or use of drugs affecting metabolism)\n* Recent (\\\u003C3 months) use of antibiotics, statins, glucocorticoids, hormonal therapies, amiodarone, or myelosuppressive agents\n* Participation in weight-loss programs or special diets (e.g., ketogenic, high-carb)\n* Shift workers or caregivers with frequent nocturnal disruptions","FEMALE","45 Years","75 Years",{"count":69,"type":70},63,"ESTIMATED","INTERVENTIONAL",[73],"NA","Type of Study: Clinical Trial\n\nGoal: The goal of this clinical trial is to investigate how performing exercise at different times of day (morning vs. evening) affects liver fat, cardiometabolic health, and gut microbiota in postmenopausal women.\n\nParticipant Population\u002FHealth Conditions: The study will involve 63 sedentary postmenopausal women (aged 45-75) diagnosed with metabolic dysfunction-associated steatotic liver disease.\n\nMain Questions: The main questions this study aims to answer are:\n\n* Does morning exercise reduce hepatic fat more effectively than evening exercise?\n* How does time-of-day-specific exercise influence cardiometabolic markers?\n* Do changes in gut microbiota contribute to the metabolic effects of exercise timing?\n\nParticipants Will:\n\nBe randomized into one of three groups: morning exercise, evening exercise, or a usual-care control group.\n\nFollow the assigned regimen for 12 weeks. The exercise groups will perform supervised aerobic and resistance training three times per week.\n\nProvide blood, stool, and imaging data before and after the intervention to determine the effects of the intervention.\n\nComparison Group:\n\nResearchers will compare the effects of morning vs. evening exercise (and usual care) on hepatic fat reduction and cardiometabolic improvement, as well as changes in gut microbiota.",[76,77,78],"Metabolic Dysfunction-Associated Steatotic Liver Disease","Cardiometabolic Diseases","Exercise",[78,80,81,82],"Metabolism","Health","Women","NOT_YET_RECRUITING","2026-05-04",{"date":86,"type":87},"2026-05-08","ACTUAL",{"date":89,"type":70},"2026-06-01",{"date":91,"type":70},"2027-12",{"name":5,"class":6},1]