[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602135":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":34,"responsibleParty":77,"collaborators":10,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":81,"sex":87,"minAge":88,"maxAge":10,"enrollmentInfo":89,"targetDuration":10,"studyType":92,"phases":10,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Hôpital le Vinatier","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Cocaine Use Disorder Group",null,"A cohort of 32 patients with cocaine use disorder will undergo repeated sleep assessment at three key stages: during active use, at the beginning of withdrawal, and after a period of sustained withdrawal. All participants will serve as their own control across timepoints",[13],"Other: Multimodal Sleep and Biomarker Assessment",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Multimodal Sleep and Biomarker Assessment","Participants will undergo non-invasive sleep assessments including polysomnography recordings (using the Somfit® device), actigraphy, self-reported questionnaires (on sleep, substance use), and urinary biomarker collection (for cortisol and melatonin levels) at three distinct stages of their substance use\u002Fwithdrawal timeline.",[9],[20],{"name":21,"affiliation":22,"role":23},"BENJAMIN ROLLAND, MD, PhD","Centre Hospitalier le Vinatier","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"ILONA MEDIGUE, PhD student","CONTACT","00334 37 91 55 65","ilona.medigue@ch-le-vinatier.fr",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},"VERONIQUE VIAL, PM","00334 37 91 55 22","veronique.vial@ch-le-vinatier.fr",[35,57,72],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Centre Hospitalier Le Vinatier","NOT_YET_RECRUITING","Bron","AURA","69500","France","FR",{"type":44,"coordinates":45},"Point",[46,47],4.91303,45.73865,{"lat":47,"lon":46},[50,53],{"name":51,"role":27,"phone":52,"phoneExt":10,"email":33},"VERONIQUE VIAL","0437915522",{"name":54,"role":27,"phone":55,"phoneExt":10,"email":56},"CORALIE PERROT","0437915531","coralie.perrot@ch-le-vinatier.fr",{"facility":36,"status":58,"city":38,"state":59,"zip":60,"country":41,"countryCode":42,"cosmosGeoPoint":61,"geoPoint":63,"contacts":64},"RECRUITING","Auvergne-Rhône-Alpes","69678 cedex",{"type":44,"coordinates":62},[46,47],{"lat":47,"lon":46},[65,69],{"name":66,"role":27,"phone":67,"phoneExt":10,"email":68},"ROLLAND BENJAMIN, MD,Ph","0033 437 915 555","benjamin.rolland@ch-le-vinatier.fr",{"name":70,"role":27,"phone":71,"phoneExt":10,"email":33},"VIAL VERONIQUE","0033 437 915 531",{"facility":73,"status":58,"city":38,"state":10,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":74,"geoPoint":76,"contacts":10},"CH Le Vinatier",{"type":44,"coordinates":75},[46,47],{"lat":47,"lon":46},{"type":78,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100602135","impact-of-cocaine-use-and-withdrawal-on-sleep-100602135",false,"NCT07119567","Impact of Cocaine Use and Withdrawal on Sleep","Longitudinal Exploration of Subjective and Objective Sleep Characteristics in Patients With Cocaine Use Disorder During the Withdrawal Process","CokeSo","Inclusion Criteria:\n\n* Male or female, aged 18 years or older\n* Meeting DSM-5 criteria for cocaine use disorder\n* Positive urine drug screen for cocaine\n* Scheduled for inpatient supervised cocaine detoxification within the next four weeks\n* Covered by a national health insurance plan or social security system\n* Have a valid, personal means of contact (telephone or email address) enabling remote follow-up at 6 months.\n\nExclusion Criteria:\n\n* Current diagnosis of opioid use disorder or other psychostimulant use disorders (e.g., amphetamines, methamphetamines, cathinones, methylphenidate)\n* Unstable psychiatric disorder or somatic illness deemed incompatible with study participation by the investigator\n* Current treatment with methylphenidate, modafinil, solriamfetol, melatonin, pitolisant, naltrexone, or bupropion\n* Patients under legal guardianship\n* Pregnant or breastfeeding women: a pregnancy test will be performed prior to inclusion for women of childbearing potential\n* Individuals deprived of liberty by judicial or administrative decision","ALL","18 Years",{"count":90,"type":91},32,"ESTIMATED","OBSERVATIONAL","This study investigates how cocaine use and withdrawal affect sleep and circadian rhythms in individuals undergoing inpatient detoxification. Using wearable sleep monitors, actigraphy, questionnaires, and hormonal biomarkers, it aims to capture both objective and subjective changes in sleep across three key stages: active use, early withdrawal, and late withdrawal. The study is unique in its ability to explore sleep microstructure, the circadian system's role via melatonin and cortisol measurements, and the dynamic relationship between subjective sleep perception and objective sleep data. It also examines whether sleep quality may serve as a predictive marker of long-term withdrawal success.",[95],"Cocaine Use Disorder",[97,98,99,100,101],"Cocaine use disorder","Withdrawal","Sleep","Polysomnography","Actimetry","2026-06-10",{"date":104,"type":105},"2026-06-11","ACTUAL",{"date":107,"type":105},"2026-03-19",{"date":109,"type":91},"2028-12-31",{"name":5,"class":6},3]