[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100450624":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":38,"locations":45,"responsibleParty":62,"collaborators":43,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":43,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":43,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":43,"overallStatus":48,"whyStopped":43,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Sodium Phosphate (NaPO4) then sodium chloride (NaCl)","EXPERIMENTAL","Participants will be asked to take 2 capsules daily of Sodium Phosphate (containing a total of 500 mg of Pi, 372mg of sodium) ) for 4 weeks during the high Pi phase (total Pi intake 1,200 mg\u002Fd). Then, participants will be asked to take 2 capsules of Sodium Chloride (NaCl, containing a total of 372mg of sodium) to match Na content to Sodium Phosphate without extra Pi daily for 4 weeks during the low Pi phase (total Pi intake = 700 mg\u002Fd).",[13,14],"Dietary Supplement: Sodium Phosphate","Dietary Supplement: Sodium Chloride",{"label":16,"type":10,"description":17,"interventionNames":18},"NaCl then NaPO4","Participants will be asked to take 2 capsules daily of Sodium Chloride (NaCl, containing a total of 372mg of sodium) for 4 weeks during the low Pi phase (total Pi intake = 700 mg\u002Fd). Then, participants will be asked to take 2 capsules of Sodium Phosphate daily for 4 weeks Sodium Phosphate (containing a total of 500 mg of Pi, 372mg of sodium) for 4 weeks during the high Pi phase (total Pi intake 1,200 mg\u002Fd).",[13,14],[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Sodium Phosphate","Sodium Phosphate 2 capsules daily (containing a total of 500 mg of Pi, 372mg of sodium)",[16,9],[26],"NaPO4",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Sodium Chloride","Sodium Chloride 2 capsules daily (NaCl, containing a total of 372mg of sodium)",[16,9],[32],"NaCl",[34],{"name":35,"affiliation":36,"role":37},"Wanpen Vongpatanasin, MD","Wanpen.Vongpatanasin@UTSouthwestern.edu","PRINCIPAL_INVESTIGATOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"John Giacona, PA-C","CONTACT","2146484403",null,"john.giacona@utsouthwestern.edu",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"University of Texas Southwestern","RECRUITING","Dallas","Texas","75209","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-96.80667,32.78306,{"lat":58,"lon":57},[61],{"name":40,"role":41,"phone":43,"phoneExt":43,"email":43},{"type":37,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Wanpen Vongpatanasin","Professor of Medicine","100450624","impact-of-dietary-phosphate-excess-on-exercise-capacity-and-visceral-adiposity-100450624",false,"NCT05147909","Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity","Inclusion Criteria:\n\nThe randomized crossover trial will be performed in on otherwise healthy subjects without diabetes mellitus, chronic kidney disease (CKD), preexisting cardiovascular disease or treatment with any vasoactive agent that might alter cardiovascular responses to exercise.\n\nExclusion Criteria:\n\n1. history of cardiopulmonary disease or chronic kidney disease,\n2. treatment with antihypertensive medications,\n3. estimated glomerular filtration rate (eGFR) \\\u003C 60 mL\u002Fmin\u002F1.73m2, (4) diabetes mellitus or other systemic illness,\n\n(5) pregnancy, (6) hypersensitivity to sodium phosphate, (7) any history of substance abuse or current cigarette use, (8) any history of psychiatric illness, (9) history of active malignancy, (10) serum phosphorus \\\u003C 2.4 or \\> 4.5 mg\u002FdL.",true,"ALL","18 Years","80 Years",{"count":76,"type":77},124,"ESTIMATED","INTERVENTIONAL",[80],"NA","Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.",[83,84,85],"Physical Inactivity","Phosphate Overload","Visceral Obesity","2026-02-13",{"date":88,"type":89},"2026-02-17","ACTUAL",{"date":91,"type":89},"2022-09-14",{"date":93,"type":77},"2028-03-30",{"name":5,"class":6},1]