[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642355":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":47,"centralContacts":52,"locations":62,"responsibleParty":79,"collaborators":82,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":34,"eligibilityCriteria":92,"healthyVolunteers":88,"sex":93,"minAge":94,"maxAge":34,"enrollmentInfo":95,"targetDuration":34,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":34,"overallStatus":106,"whyStopped":34,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Milton S. Hershey Medical Center","OTHER",[8,15,21,25],{"label":9,"type":10,"description":11,"interventionNames":12},"High Wattage\u002FHigh Propylene Glycol","EXPERIMENTAL","High temperature and high propylene glycol concentration",[13,14],"Other: High temperature wattage setting on electronic cigarette","Other: High concentration of Propylene Glycol",{"label":16,"type":10,"description":17,"interventionNames":18},"Low Wattage\u002FLow Propylene Glycol","Low temperature and low propylene glycol concentration",[19,20],"Other: Low temperature wattage setting on electronic cigarette","Other: Low concentration of Propylene Glycol",{"label":22,"type":10,"description":23,"interventionNames":24},"High Wattage\u002FLow Propylene Glycol","High temperature and low propylene glycol concentration",[13,20],{"label":26,"type":10,"description":27,"interventionNames":28},"Low Wattage\u002FHigh Propylene Glycol","Low temperature and high propylene glycol concentration",[19,14],[30,35,39,43],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"High temperature wattage setting on electronic cigarette","Study provided electronic cigarette will be set to a high wattage resulting in a higher usage temperature (275 C)",[9,22],null,{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Low temperature wattage setting on electronic cigarette","Study provided electronic cigarette will be set to a low wattage resulting in a lower usage temperature (200 C)",[26,16],{"type":6,"name":40,"description":41,"armGroupLabels":42,"otherNames":34},"High concentration of Propylene Glycol","Study provided electronic cigarette liquid will have a higher percentage of propylene glycol (90%)",[9,26],{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":34},"Low concentration of Propylene Glycol","Study provided electronic cigarette liquid will have a higher percentage of propylene glycol (10%)",[22,16],[48],{"name":49,"affiliation":50,"role":51},"Zachary Bitzer, Ph.D.","Penn State Hershey College of Medicine","PRINCIPAL_INVESTIGATOR",[53,58],{"name":54,"role":55,"phone":56,"phoneExt":34,"email":57},"Zachary Btizer, Ph. D.","CONTACT","717-531-4387","zbitzer@pennstatehealth.psu.edu",{"name":59,"role":55,"phone":60,"phoneExt":34,"email":61},"Kenneth Houser, MS","717-531-5473","khouser@pennstatehealth.psu.edu",[63],{"facility":64,"status":34,"city":65,"state":66,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":76},"Penn State College of Medicine","Hershey","Pennsylvania","17033","United States","US",{"type":71,"coordinates":72},"Point",[73,74],-76.65025,40.28592,{"lat":74,"lon":73},[77,78],{"name":59,"role":55,"phone":60,"phoneExt":34,"email":61},{"name":49,"role":51,"phone":34,"phoneExt":34,"email":34},{"type":51,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"Zachary Bitzer","Assistant Professor, Department of Public Health Sciences",[83],{"name":84,"class":85},"National Institute on Drug Abuse (NIDA)","NIH","100642355","impact-of-electronic-cigarette-temperature-and-solvent-on-biomarkers-100642355",false,"NCT07612696","Impact of Electronic Cigarette Temperature and Solvent on Biomarkers","Clinical Study on the Impact of Electronic Cigarette Temperature and Solvent on Biomarkers of Oxidant Exposure","Inclusion Criteria:\n\n* 21 years of age or older\n* Normal pulmonary and cardiovascular function with no history of COPD or cardiovascular disease (excluding hypertension)\n* Current exclusive use of a sub-ohm\u002Fmod or pod EC devices (≥ 1mL e-liquid\u002Fper day, ≥6 mg\u002Fml nicotine concentration, EC for ≥ 1 year)\n* No plan on quitting nicotine use over the course of the study\n* All other forms of nicotine must be used \\\u003C5 days out of the past 28 days.\n* Able to read and write in English\n* Have access to email and a smartphone\u002Fcomputer that has reliable internet connection\n\nExclusion Criteria:\n\n* Women who are pregnant and\u002For nursing or trying to become pregnant\n* Unstable or significant medical condition in the past 3 months (e.g., recent heart attack or other serious heart condition, stroke, severe angina)\n* Respiratory diseases (e.g., exacerbations of asthma or COPD, require oxygen, require oral prednisone), kidney (e.g., dialysis) or liver disease (e.g., cirrhosis), severe immune system disorders (e.g., uncontrolled HIV\u002FAIDS, multiple sclerosis symptoms) or any medical disorder\u002Fmedication that may affect participant safety or biomarker data\n* Uncontrolled substance abuse or inpatient treatment for that condition in the past 6 months\n* Have immediate family or household members currently participating in this trial","ALL","21 Years",{"count":96,"type":97},50,"ESTIMATED","INTERVENTIONAL",[100],"NA","This project seeks to determine how e-cigarette (EC) physical design features, including those that allow the user to manipulate the quality and quantity of aerosols, affect exposure and toxicity from oxidants and other aerosol constituents.",[103,104,105],"Oxidative Stress","Tobacco Use","Electronic Cigarettes","NOT_YET_RECRUITING","2026-06-12",{"date":109,"type":110},"2026-06-16","ACTUAL",{"date":112,"type":97},"2026-07-15",{"date":114,"type":97},"2028-12",{"name":5,"class":6},1]