[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100477248":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":72,"collaborators":75,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":26,"eligibilityCriteria":84,"healthyVolunteers":80,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":26,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":103,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Peking University First Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Erector spinae plane block group","EXPERIMENTAL","Prior to general anesthesia, ultrasound guided erector spinae plane block (ESPB; performed with 0.5% ropivacaine 35 ml with dexmedetomidine 1microgram\u002Fkg) is performed at T2 level (15 ml) and T4 level (20 ml).",[13],"Procedure: Erector spinae plane block",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","SHAM_COMPARATOR","General anesthesia alone.",[19],"Procedure: Control group",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Erector spinae plane block","Prior to general anesthesia, ultrasound guided erector spinae plane block (ESPB; performed with 0.5% ropivacaine 35 ml with dexmedetomidine 1 microgram\u002Fkg) is performed at T2 level (15 ml) and T4 level (20 ml).",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":28,"otherNames":26},[15],[30],{"name":31,"affiliation":5,"role":32},"Dong-Xin Wang, M.D., Ph.D.","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":26,"email":38},"Qiongfang Wu, M.D.","CONTACT","+8618310161109","wuqf91@163.com",{"name":31,"role":36,"phone":40,"phoneExt":26,"email":41},"+86 13910731903","wangdongxin@hotmail.com",[43,61],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Beijing","Beijing Municipality","100034","China","CN",{"type":51,"coordinates":52},"Point",[53,54],116.39723,39.9075,{"lat":54,"lon":53},[57],{"name":58,"role":36,"phone":59,"phoneExt":26,"email":60},"Zeng-Mao Lin, M.D.","+86 13810098351","Linzengmao@163.com",{"facility":62,"status":44,"city":45,"state":46,"zip":63,"country":48,"countryCode":49,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"Beijing Cancer Hospital","100142",{"type":51,"coordinates":65},[53,54],{"lat":54,"lon":53},[68],{"name":69,"role":36,"phone":70,"phoneExt":26,"email":71},"Ling Yu, M.D.","+86 13146203116","fishyu071@sina.com",{"type":32,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Dong-Xin Wang","Professor",[76],{"name":77,"class":6},"Peking University Cancer Hospital & Institute","100477248","impact-of-erector-spinae-plane-block-on-chronic-postsurgical-pain-in-breast-cancer-patients-100477248",false,"NCT05494502","Impact of Erector Spinae Plane Block on Chronic Postsurgical Pain in Breast Cancer Patients","Impact of Erector Spinae Plane Block With Adjuvant Dexmedetomidine on Chronic Postsurgical Pain in Breast Cancer Patients: a Two-center Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age of 18 years or over, but less than 85 years;\n2. Scheduled to undergo mastectomy for primary unilateral breast cancer.\n\nExclusion Criteria:\n\n1. Previous breast cancer surgery with an incision of \\>2 cm;\n2. Chronic opioid dependence or long-term intake of analgesic medicines (\\>3 months);\n3. Any contraindication to erector spinae plane block, including intrathoracic infection, infection at the puncture site, cancer invasion of the puncture site, severe spinal deformity, history of spinal surgery, and severe coagulopathy;\n4. Inability to communicate in the preoperative period because of profound dementia, deafness, language barriers, or end-stage disease;\n5. History of malignant tumor in other organs, or a current combination of malignant tumor of other organs;\n6. History of coronary heart disease (diagnosed coronary stenosis, previous myocardial infarction, previous percutaneous coronary intervention or coronary artery bypass grafting); preoperative hepatic or renal impairment (alanine transaminase and\u002For aspartate transaminase ≥2 times of upper limit of normal, or serum creatinine\\>133 µmol\u002FL); history of peptic ulcer or hemorrhage; ASA classification IV or above;\n7. Allergy to ropivacaine.","ALL","18 Years","85 Years",{"count":89,"type":90},1206,"ESTIMATED","INTERVENTIONAL",[93],"NA","Chronic postsurgical pain (CPSP) has an incidence of 46% in patients after breast cancer surgery, which seriously affects patients' physiological and psychological function, as well as quality of life. Acute pain is an independent risk factor for persistent pain after surgery. Erector spinae plane block (ESPB) provided excellent perioperative analgesia in patients undergoing breast surgery. Dexmedetomidine as an adjuvant of local anesthetics prolongs the duration of peripheral nerve block and decreases the requirements of postoperative analgesia. The investigators hypothesize that, for breast cancer patients undergoing mastectomy, ESPB (with a combination of 0.5% ropivacaine 35 ml and dexmedetomidine 1 microgram\u002Fkg) can reduce the occurrence of CPSP. The purpose of this randomized controlled trial is to investigate the impact of ESPB with adjuvant dexmedetomidine on the incidence of CPSP in breast cancer patients after mastectomy. We will also observe the impact of ESPB on long-term survival in these patients.",[96,97,98,99,100,101,102],"Breast Neoplasms","Mastectomy","Nerve Block","Dexmedetomidine","Pain, Postoperative","Chronic Pain","Prognosis",[104,97,23,99,105,106,107],"Breast cancer","Postoperative pain","Chronic postsurgical pain","Long-term prognosis","2025-07-29",{"date":110,"type":111},"2025-07-31","ACTUAL",{"date":113,"type":111},"2023-05-23",{"date":115,"type":90},"2027-07",{"name":5,"class":6},2]