[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100457397":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":44,"responsibleParty":76,"collaborators":25,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":80,"sex":86,"minAge":87,"maxAge":25,"enrollmentInfo":88,"targetDuration":25,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Dana-Farber Cancer Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise Group","EXPERIMENTAL","Home-based, virtually supervised via Zoom, 3x weekly for 12-weeks aerobic and resistance exercise program\n\nParticipants will also undergo four testing visits across 6-month period. Tests will include four blood draws and three body composition scans via a dual-energy x-ray absorptiometry (DXA).",[13],"Behavioral: Exercise",{"label":15,"type":10,"description":16,"interventionNames":17},"Attention control Group","Home-based, 12-week stretching program only with participants asked not to change their activity behavior.\n\nParticipants will also undergo four testing visits across 6-month period. Tests will include four blood draws and three body composition scans via a dual-energy x-ray absorptiometry (DXA).",[18],"Behavioral: Attention control",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Exercise","aerobic and resistance exercise",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Attention control","stretching",[15],[31],{"name":32,"affiliation":5,"role":33},"Christina Dieli-Conwright","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Christina Dieli-Conwright, PhD, MPH","CONTACT","617-582-8321","ChristinaM_Dieli-Conwright@dfci.harvard.edu",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},"Jordan Lane, MS","617-582-7494","jordan_lane@dfci.harvard.edu",[45,63],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Brigham and Women's Hospital","RECRUITING","Boston","Massachusetts","02115","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-71.05977,42.35843,{"lat":57,"lon":56},[60,62],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":61},"ChristinaM_Dieli-Conwright@DFCI.HARVARD.EDU",{"name":36,"role":33,"phone":25,"phoneExt":25,"email":25},{"facility":64,"status":47,"city":48,"state":49,"zip":65,"country":51,"countryCode":52,"cosmosGeoPoint":66,"geoPoint":68,"contacts":69},"Dana Farber Cancer Institute","02215",{"type":54,"coordinates":67},[56,57],{"lat":57,"lon":56},[70,72,74],{"name":36,"role":37,"phone":71,"phoneExt":25,"email":39},"617-632-3800",{"name":73,"role":37,"phone":25,"phoneExt":25,"email":25},"PhD, MPH",{"name":75,"role":33,"phone":25,"phoneExt":25,"email":25},"Christina Dieli-Conwright, PhD",{"type":33,"investigatorFullName":75,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Principal Investigator","100457397","impact-of-exercise-on-the-complications-of-corticosteroids-in-patients-with-gvhd-the-restart-trial-100457397",false,"NCT05236062","Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial","Impact of Exercise on the Complications of Corticosteroids in Patients With Graft-Versus-Host Disease Following Allogeneic Stem Cell Transplantation: the RESTART Trial","RESTART","Inclusion Criteria:\n\n* Over 18 years old; children under the age of 18 will be excluded due to rarity of disease\n* Newly diagnosed with acute or chronic GVHD, starting corticosteroids at a dose of .20 mg\u002Fkg or greater for the first time since transplant\n* Received allogeneic stem cell transplant (any conditioning, any donor) at Dana-Farber Cancer Institute\n* Physician's clearance to participate in moderate-vigorous intensity exercise\n* Speak English\n* Currently participate in less than 60 minutes of structured exercise\u002Fweek\n* Willing to travel to Dana-Farber Cancer Institute for necessary data collection\n* Ability to understand and the willingness to sign a written informed consent document.\n\nExclusion Criteria:\n\n* Have a plan for hospital admission within the next 13 weeks at the time of recruitment\n* If patients are not enrolled within 14 days after initial steroid treatment, they will be ineligible\n* Pre-existing musculoskeletal or cardiorespiratory conditions\n* Patients should not have any uncontrolled illness including ongoing or active infection, uncontrolled diabetes, hypertension, or thyroid disease\n* Patients may not be receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy\n* Patients with other active malignancies\n* Participate in more than 60 minutes of structured exercise\u002Fweek\n* Unable to travel to Dana-Farber Cancer Institute for necessary data collection\n* Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study.","ALL","18 Years",{"count":89,"type":90},36,"ESTIMATED","INTERVENTIONAL",[93],"NA","This study is about determining if an aerobic and resistance exercise intervention is feasible in patients diagnosed with acute or chronic GVHD (Graft-Versus-Host Disease) after having an allogeneic stem cell transplant.\n\nThe names of the study interventions involved in this study are:\n\n* Aerobic and resistance exercise (A+R) - Home-based aerobic and resistance exercise program\n* Attention control (AC) - Home-based stretching program",[96,97,98],"Graft Vs Host Disease","Acute-graft-versus-host Disease","Chronic Graft-versus-host-disease",[96,97,98,100,101],"Corticosteroids","Allogeneic stem cell transplant","2026-03-09",{"date":104,"type":105},"2026-03-11","ACTUAL",{"date":107,"type":105},"2022-04-14",{"date":109,"type":90},"2027-09-09",{"name":5,"class":6},2]