[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556802":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":34,"locations":43,"responsibleParty":75,"collaborators":78,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":82,"sex":88,"minAge":89,"maxAge":18,"enrollmentInfo":90,"targetDuration":18,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":18,"overallStatus":64,"whyStopped":18,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Bispebjerg Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise","ACTIVE_COMPARATOR","The exercise intervention consists of supervised training 40-50 minutes x 3 weekly for 12 weeks.",[13],"Other: Exercise training",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","The participants who are randomized to the no-training group will be offered exercise train-ing after the intervention is completed. Participants will be encouraged to not change their lifestyle or medication throughout the study period.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Exercise training","The training sessions are consist of cycling and as follows: a 10 min warm-up at a light intensity, 20-35 min of cycling exercise in intervals at varying intensities from light (\\~60% of max heart rate) to more intensive (80-90% of max heart rate) and ending with 5 min of warm-down at a light intensity. The training intensity will be progressive during the course of the intervention period. The cycling training sessions are supervised .\n\nHome training is allowed up to once a week if participants are able to adhere to the prescribed intensity levels.\n\nTraining sessions are closely monitored to ensure effectiveness and safety. This includes heart rate monitoring, perceived exertion assessment.",[9],[25,26],"Physical activity","Endurance training",[28,32],{"name":29,"affiliation":30,"role":31},"Eva Prescott, MD, DMSc","University of Copenhagen","PRINCIPAL_INVESTIGATOR",{"name":33,"affiliation":30,"role":31},"Ylva Hellsten",[35,39],{"name":29,"role":36,"phone":37,"phoneExt":18,"email":38},"CONTACT","004522572614","Eva.Irene.Bossano.Prescott@regionh.dk",{"name":40,"role":36,"phone":41,"phoneExt":18,"email":42},"Mads Fischer, MSc","+45 23 46 36 66","mf@nexs.ku.dk",[44,62],{"facility":45,"status":46,"city":47,"state":18,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57, Frederiksberg, Denmark, 2000","NOT_YET_RECRUITING","Copenhagen","2400","Denmark","DK",{"type":52,"coordinates":53},"Point",[54,55],12.56553,55.67594,{"lat":55,"lon":54},[58,60],{"name":29,"role":36,"phone":59,"phoneExt":18,"email":38},"+45 4026 2134",{"name":40,"role":36,"phone":61,"phoneExt":18,"email":42},"+4524485450",{"facility":63,"status":64,"city":65,"state":18,"zip":66,"country":49,"countryCode":50,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57","RECRUITING","Frederiksberg","2000",{"type":52,"coordinates":68},[69,70],12.53463,55.67938,{"lat":70,"lon":69},[73,74],{"name":29,"role":36,"phone":59,"phoneExt":18,"email":38},{"name":40,"role":36,"phone":61,"phoneExt":18,"email":42},{"type":31,"investigatorFullName":76,"investigatorTitle":77,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Eva Prescott","MD Clinical Professor",[79],{"name":30,"class":6},"100556802","impact-of-exercise-training-on-ischemia-with-non-obstructive-coronary-arteries-inoca-the-exinoca-study-100556802",false,"NCT06529848","Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study","Ischemia With No Obstruction of Coronary Arteries: Underlying Mechanisms and the Impact of Exercise Training (EXINOCA)","ExINOCA","Inclusion Criteria:\n\n* Coronary microvascular dysfunction, defined as myocardial bloodflow reserve (MBFR) \\\u003C 2.5 or hyperemic myocar-dial blood flow (hMBF)\\\u003C2.3 ml\u002Fg\u002Fmin using \\[15O\\]H2O-PET\n* No obstructive coronary artery disease\n\nExclusion Criteria:\n\n* Females of childbearing potential (defined as a premeno-pausal female capable of becoming pregnant). The female patient must either be postmenopausal, defined as amen-orrhea for at least 1 year, or surgically sterile\n* Heart failure, defined as left ventricular ejection fraction of less than 40%\n* Uncontrolled hypertension defined as blood pressure above target 140\u002F90 for all\n* Co-morbidity resulting in \\\u003C1 year expected survival\n* Considered by the investigator, for any reason, to be an un-suitable candidate for the study.\n* Unable or unwilling to exercise, e.g. due to arthritis or in-jury\\*\n* Already are regularly physically active and\u002For have a maxi-mal oxygen uptake \\>45 ml\u002Fkg\u002Fmin","ALL","50 Years",{"count":91,"type":92},100,"ESTIMATED","INTERVENTIONAL",[95],"NA","The purpose of the study is to identify causes of chest pain in patients experiencing chest pain with no signs of narrowing of the coronary arteries of the heart, and to investigate whether physical exercise can improve coronary microvascular function.\n\nHypotheses:\n\nThe first hypothesis is that in INOCA, with reduced function of microvasculature of the heart, this reduced function also occurs in other organs of the body.\n\nThe second hypothesis is that regular physical activity (aerobic exercise training) can improve coronary microvascular function, reduce symptoms, and that there is a parallel improvement in vascular function in other organs of the body.",[98,99],"Coronary Microvascular Disease","CMD","2025-02-20",{"date":102,"type":103},"2025-02-21","ACTUAL",{"date":105,"type":103},"2024-11-01",{"date":107,"type":92},"2028-05-15",{"name":5,"class":6},2]