[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632986":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":17,"centralContacts":22,"locations":28,"responsibleParty":40,"collaborators":17,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":17,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":17,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":67,"whyStopped":17,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Firat University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise","EXPERIMENTAL","Based on current recommendations for individuals with MS, the PRT program will last 12 weeks and will include three sessions per week, each lasting 60-90 minutes at 60-80% of one-repetition maximum.",[13],"Other: Exercise",{"label":15,"type":16,"description":17,"interventionNames":17},"Control","NO_INTERVENTION",null,[19],{"type":6,"name":9,"description":20,"armGroupLabels":21,"otherNames":17},"According to current clinical guidelines for multiple sclerosis patients, the progressive resistance training (PRT) protocol will be implemented as follows: a 12-week intervention consisting of three supervised 60-90 minute sessions per week at 60-80% of one-repetition maximum intensity. All training sessions will be conducted under the direct supervision of a certified physiotherapist to ensure proper technique adherence and safety throughout the intervention period",[9],[23],{"name":24,"role":25,"phone":26,"phoneExt":17,"email":27},"Furkan Bilek, PhD","CONTACT","+905442772249","fzt.furkanbilek@gmail.com",[29],{"facility":30,"status":17,"city":31,"state":17,"zip":32,"country":33,"countryCode":17,"cosmosGeoPoint":34,"geoPoint":39,"contacts":17},"Fırat University","Elâzığ","23100","Turkey (Türkiye)",{"type":35,"coordinates":36},"Point",[37,38],39.22321,38.67431,{"lat":38,"lon":37},{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"PRINCIPAL_INVESTIGATOR","Furkan Bilek","Principal Investigator","100632986","impact-of-exercise-training-on-serum-neurofilament-light-chain-nfl-brain-volumetry-and-functional-outcomes-in-multiple-sclerosis-100632986",false,"NCT07520812","Impact of Exercise Training on Serum Neurofilament Light Chain (NfL), Brain Volumetry, and Functional Outcomes in Multiple Sclerosis","The Effect of an Exercise Intervention on Serum Neurofilament Light Chain and Brain Volumetry in Patients With Multiple Sclerosis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Clinically confirmed relapsing-remitting multiple sclerosis (RRMS) diagnosis according to revised McDonald criteria (2017)\n* Mild-to-moderate disability (EDSS score 1.0-5.5)\n* No corticosteroid treatment within the previous 3 months\n\nExclusion Criteria:\n\n* Acute MS relapse within 90 days prior to enrollment\n* Regular participation in structured exercise programs (\\>3 hours\u002Fweek)\n* Comorbid conditions that may limit exercise participation, including; significant orthopedic impairments, unstable cardiopulmonary conditions and other systemic disorders affecting physical activity\n* Standard MRI contraindications (metallic implants, claustrophobia, etc.)\n* Concurrent neurological disorders (other than MS)\n* Initiation or modification of disease-modifying therapy within 6 months\n* Severe spasticity (Modified Ashworth Scale ≥3 in any major muscle group)","ALL","18 Years","65 Years",{"count":55,"type":56},26,"ESTIMATED","INTERVENTIONAL",[59],"NA","This single-blind, randomized controlled trial will employ a two-arm parallel design (exercise group vs. control group) with a 12-week intervention period. Randomization will be implemented using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) to ensure balanced group allocation. All outcome measures will be assessed at baseline and post-intervention.",[62,9,63],"Multiple Sclerosis","Neurofilament Light Chain",[9,65,66],"Neurofilament light chain","Brain Volume","NOT_YET_RECRUITING","2026-04-03",{"date":70,"type":71},"2026-04-09","ACTUAL",{"date":73,"type":56},"2026-04-15",{"date":75,"type":56},"2026-08-15",{"name":5,"class":6},1]