[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100479345":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":41,"responsibleParty":298,"collaborators":300,"id":306,"slug":307,"hasResults":308,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":308,"sex":314,"minAge":315,"maxAge":18,"enrollmentInfo":316,"targetDuration":18,"studyType":319,"phases":320,"briefSummary":322,"conditions":323,"keywords":325,"overallStatus":44,"whyStopped":18,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":336},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"With first trimester preeclampsia screening","EXPERIMENTAL","Risk assessment of developing preeclampsia between 11 and 14 WG based on maternal parameters, blood pressure measurement, Doppler measurements of the uterine arteries and maternal PlGF concentration. Patients at high risk of preeclampsia are treated with aspirin.",[13],"Procedure: First-trimester preeclampsia screening (FMF triple test)",{"label":15,"type":16,"description":17,"interventionNames":18},"Without first trimester preeclampsia screening","NO_INTERVENTION","Usual prenatal care",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","First-trimester preeclampsia screening (FMF triple test)","An algorithm assessing the risk of developing preeclampsia combining maternal parameters, blood pressure measurement, Doppler measurements of the uterine arteries and maternal PlGF concentrations.\n\nFor women in the screening group, a Doppler study of the uterine arteries and a blood test to quantify PlGF concentrations will be performed within 2 days of randomization, allowing the risk to be calculated according to the screening test. For women with a positive screening test (i.e. predicted risk\\> 1\u002F100), a treatment with aspirin will be prescribed at 160 mg\u002Fday, started as soon as possible and before 15 WG, and taken up to 36 WG, in the absence of contraindications. For women with negative screening, usual pregnancy monitoring without aspirin will be offered.",[9],[26],{"name":27,"affiliation":28,"role":29},"Catherine DENEUX, MD, PhD","Institut National de la Santé Et de la Recherche Médicale, France","STUDY_DIRECTOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":18,"email":35},"Vassilis TSATSARIS, MD, PhD","CONTACT","01 58 41 38 71","vassilis.tsatsaris@aphp.fr",{"name":37,"role":33,"phone":38,"phoneExt":39,"email":40},"Valérie PLENCE, MSc","01 58 41 11 78","+33","valerie.plence-fauroux@aphp.fr",[42,58,70,82,94,106,118,132,144,156,165,177,189,201,209,218,230,242,254,265,274,286],{"facility":43,"status":44,"city":45,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"CHU Angers","RECRUITING","Angers","France","FR",{"type":49,"coordinates":50},"Point",[51,52],-0.55202,47.47156,{"lat":52,"lon":51},[55],{"name":56,"role":33,"phone":18,"phoneExt":18,"email":57},"Guillaume LEGENDRE","guillaume.legendre@chu-angers.fr",{"facility":59,"status":44,"city":60,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"CHU de Bordeaux","Bordeaux",{"type":49,"coordinates":62},[63,64],-0.58046,44.84124,{"lat":64,"lon":63},[67],{"name":68,"role":33,"phone":18,"phoneExt":18,"email":69},"Loïc SENTILHES, Pr","loic.sentilhes@chu-bordeaux.fr",{"facility":71,"status":44,"city":72,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Hôpital Femme Mère Enfant","Bron",{"type":49,"coordinates":74},[75,76],4.91303,45.73865,{"lat":76,"lon":75},[79],{"name":80,"role":33,"phone":18,"phoneExt":18,"email":81},"Anthony ATTALAH, Dr","anthony.attalah@chu-lyon.fr",{"facility":83,"status":44,"city":84,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Hôpital Antoine Béclère","Clamart",{"type":49,"coordinates":86},[87,88],2.26692,48.80299,{"lat":88,"lon":87},[91],{"name":92,"role":33,"phone":18,"phoneExt":18,"email":93},"Alexandra LETOURNEAU, Dr","letourneau.alexandra@aphp.fr",{"facility":95,"status":44,"city":96,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"CHU Estaing","Clermont-Ferrand",{"type":49,"coordinates":98},[99,100],3.08682,45.77969,{"lat":100,"lon":99},[103],{"name":104,"role":33,"phone":18,"phoneExt":18,"email":105},"Denis GALOT, Dr","dgallot@chu-clermontferrand.fr",{"facility":107,"status":44,"city":108,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Hôpital Intercommunal Créteil","Créteil",{"type":49,"coordinates":110},[111,112],2.46569,48.79266,{"lat":112,"lon":111},[115],{"name":116,"role":33,"phone":18,"phoneExt":18,"email":117},"Edouard LECARPENTIER, Dr","edouard.lecarpentier@chircreteil.fr",{"facility":119,"status":44,"city":120,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"CHU Dijon Bourgogne","Dijon",{"type":49,"coordinates":122},[123,124],5.01391,47.31344,{"lat":124,"lon":123},[127,130],{"name":128,"role":33,"phone":18,"phoneExt":18,"email":129},"Emmanuel SIMON, Dr","emmanuel.simon@chu-dijon.fr",{"name":131,"role":33,"phone":18,"phoneExt":18,"email":18},"Emmanuel.Simon@u-bourgogne.fr",{"facility":133,"status":44,"city":134,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"CHU Lille","Lille",{"type":49,"coordinates":136},[137,138],3.05512,50.63391,{"lat":138,"lon":137},[141],{"name":142,"role":33,"phone":18,"phoneExt":18,"email":143},"Louise GHESQUIERE, PhD","louise.ghesquiere@chu-lille.fr",{"facility":145,"status":44,"city":146,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":147,"geoPoint":151,"contacts":152},"Hôpital de la conception et de la Timone","Marseille",{"type":49,"coordinates":148},[149,150],5.38107,43.29695,{"lat":150,"lon":149},[153],{"name":154,"role":33,"phone":18,"phoneExt":18,"email":155},"Florence BRETELLE, Pr","florence.bretelle@ap-hm.fr",{"facility":157,"status":44,"city":146,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":158,"geoPoint":160,"contacts":161},"Hôpital Nord",{"type":49,"coordinates":159},[149,150],{"lat":150,"lon":149},[162],{"name":163,"role":33,"phone":18,"phoneExt":18,"email":164},"Julie BLANC, Dr","julievirginie.blanc@ap-hm.fr",{"facility":166,"status":44,"city":167,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":168,"geoPoint":172,"contacts":173},"CHRU de Nancy","Nancy",{"type":49,"coordinates":169},[170,171],6.18496,48.68439,{"lat":171,"lon":170},[174],{"name":175,"role":33,"phone":18,"phoneExt":18,"email":176},"Olivier MOREL, MD, PhD","o.morel@chru-nancy.fr",{"facility":178,"status":44,"city":179,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":180,"geoPoint":184,"contacts":185},"Hôpital Femme - Maternité","Nantes",{"type":49,"coordinates":181},[182,183],-1.55336,47.21725,{"lat":183,"lon":182},[186],{"name":187,"role":33,"phone":18,"phoneExt":18,"email":188},"Norber WINER, Pr","norbert.winer@chu-nantes.fr",{"facility":190,"status":44,"city":191,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"Hôpital Armand Trousseau","Paris",{"type":49,"coordinates":193},[194,195],2.3488,48.85341,{"lat":195,"lon":194},[198],{"name":199,"role":33,"phone":18,"phoneExt":18,"email":200},"Gilles KAYEM, Pr","gilles.kayem@aphp.fr",{"facility":202,"status":44,"city":191,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":203,"geoPoint":205,"contacts":206},"Hôpital Cochin (site Port-Royal)",{"type":49,"coordinates":204},[194,195],{"lat":195,"lon":194},[207],{"name":208,"role":33,"phone":18,"phoneExt":18,"email":35},"Vassilis TSATSARIS, Pr",{"facility":210,"status":44,"city":191,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":211,"geoPoint":213,"contacts":214},"Hôpital Saint-Joseph",{"type":49,"coordinates":212},[194,195],{"lat":195,"lon":194},[215],{"name":216,"role":33,"phone":18,"phoneExt":18,"email":217},"Elie AZRIA, Pr","eazria@ghpsj.fr",{"facility":219,"status":44,"city":220,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":221,"geoPoint":225,"contacts":226},"CHI de Poissy","Poissy",{"type":49,"coordinates":222},[223,224],2.04952,48.92902,{"lat":224,"lon":223},[227],{"name":228,"role":33,"phone":18,"phoneExt":18,"email":229},"Paul BERVEILLER, Pr","paul.berveiller@ght-yvelinesnord.fr",{"facility":231,"status":44,"city":232,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"Hôpital Sud Rennes","Rennes",{"type":49,"coordinates":234},[235,236],-1.67431,48.11109,{"lat":236,"lon":235},[239],{"name":240,"role":33,"phone":18,"phoneExt":18,"email":241},"Maela LELOUS, Dr","Maela.LE.LOUS@chu-rennes.fr",{"facility":243,"status":44,"city":244,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":245,"geoPoint":249,"contacts":250},"CHU Charles Nicolle","Rouen",{"type":49,"coordinates":246},[247,248],1.09932,49.44313,{"lat":248,"lon":247},[251],{"name":252,"role":33,"phone":18,"phoneExt":18,"email":253},"Eric VERSPYCK, Pr","eric.verspyck@chu-rouen.fr",{"facility":255,"status":44,"city":256,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":257,"geoPoint":261,"contacts":262},"CHU Strasbourg, CMCO Schiltigheim","Strasbourg",{"type":49,"coordinates":258},[259,260],7.74553,48.58392,{"lat":260,"lon":259},[263],{"name":264,"role":33,"phone":18,"phoneExt":18,"email":18},"AS WEINGERTNER, Dr",{"facility":266,"status":44,"city":256,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":267,"geoPoint":269,"contacts":270},"Hôpital de Hautepierre",{"type":49,"coordinates":268},[259,260],{"lat":260,"lon":259},[271],{"name":272,"role":33,"phone":18,"phoneExt":18,"email":273},"Anne-Sophie WEINGERTNER, Dr","anne-sophie.weingertner@chru-strasbourg.fr",{"facility":275,"status":44,"city":276,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":277,"geoPoint":281,"contacts":282},"Hôpital Paule de Viguier","Toulouse",{"type":49,"coordinates":278},[279,280],1.44367,43.60426,{"lat":280,"lon":279},[283],{"name":284,"role":33,"phone":18,"phoneExt":18,"email":285},"Paul GUERBY, Dr","guerby.p@chu-toulouse.fr",{"facility":287,"status":44,"city":288,"state":18,"zip":18,"country":46,"countryCode":47,"cosmosGeoPoint":289,"geoPoint":293,"contacts":294},"Hôpital Bretonneau","Tours",{"type":49,"coordinates":290},[291,292],0.70398,47.39484,{"lat":292,"lon":291},[295],{"name":296,"role":33,"phone":18,"phoneExt":18,"email":297},"Franck PERROTIN, Pr","franck.perrotin@univ-tours.fr",{"type":299,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[301,304],{"name":302,"class":303},"INSERM, Epopé team","UNKNOWN",{"name":305,"class":6},"URC-CIC Paris Descartes Necker Cochin","100479345","impact-of-first-trimester-preeclampsia-screening-on-perinatal-and-maternal-morbidity-ranspre-100479345",false,"NCT05521776","Impact of First-trimester Preeclampsia Screening on Perinatal and Maternal Morbidity (RANSPRE)","Impact of First-trimester Preeclampsia Screening on Perinatal and Maternal Morbidity : a Multicenter Randomized Trial","RANSPRE","Inclusion Criteria :\n\n* Pregnancy between 11 and 14 WG\n* Age ≥18 years\n* Affiliated to or beneficiary of a health insurance system (including AME)\n* Signed informed consent\n\nExclusion Criteria :\n\n* Gestational age \\\u003C11 WG or \\>14 WG\n* Known ectopic pregnancy\n* Known non-ongoing pregnancy\n* Known multiple pregnancy\n* History of PE in a previous pregnancy\n* Pregnancies complicated by major fetal abnormality identified at the first-trimester ultrasound if performed before randomization\n* Absence of health insurance\n* Contra-indication to aspirin (bleeding disorders such as von Willebrand's disease, active peptic ulceration, hypersensitivity to aspirin, active peptic ulceration, NSAID-exacerbated respiratory disease, severe liver or heart dysfunction)\n* Women taking low-dose aspirin regularly and started before pregnancy (except ART indication)\n* Age \\\u003C18 years\n* Poor understanding of the French language","FEMALE","18 Years",{"count":317,"type":318},14500,"ESTIMATED","INTERVENTIONAL",[321],"NA","The purpose of this study is to determine whether first-trimester screening for preeclampsia based on the FMF algorithm (a combination of maternal clinical, sonographic and biochemical parameters), improves maternal or perinatal health.",[324],"Preeclampsia (PE)",[326],"Preeclampsia","2026-03-24",{"date":329,"type":330},"2026-03-27","ACTUAL",{"date":332,"type":330},"2023-03-06",{"date":334,"type":318},"2027-02",{"name":5,"class":6},22]