[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640946":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":10,"centralContacts":19,"locations":28,"responsibleParty":58,"collaborators":62,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":10,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":10,"enrollmentInfo":79,"targetDuration":82,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Shanghai Zhongshan Hospital","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":11},"Single cohort, self-controlled",null,[12],"Diagnostic Test: Angiography-derived IMR",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"DIAGNOSTIC_TEST","Angiography-derived IMR","Unlike the reference standard \"Wire-IMR,\" which requires the advancement of a specialized pressure-sensor guidewire into the distal coronary artery, Angio-IMR is a wire-free technology. It derives microvascular resistance indices purely through computational fluid dynamics (CFD) or specialized mathematical models based on standard coronary angiographic projections. This eliminates the risk of wire-induced vascular injury or spasm.",[9],[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Chenguang Li, MD, PhD","CONTACT","021 6404 1990","li.chenguang@zs-hospital.sh.cn",{"name":26,"role":22,"phone":10,"phoneExt":10,"email":27},"Jinying Zhou, MD, PhD","zhou.jinying@zs-hospital.sh.cn",[29,45],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Zhongshan Hospital, Fudan University","RECRUITING","Shanghai","Please Select","200000","China","CN",{"type":38,"coordinates":39},"Point",[40,41],121.45806,31.22222,{"lat":41,"lon":40},[44],{"name":26,"role":22,"phone":23,"phoneExt":10,"email":27},{"facility":46,"status":31,"city":47,"state":10,"zip":10,"country":35,"countryCode":36,"cosmosGeoPoint":48,"geoPoint":52,"contacts":53},"The First Affiliated Hospital, Sun Yat-sen University","Guangzhou",{"type":38,"coordinates":49},[50,51],113.25,23.11667,{"lat":51,"lon":50},[54],{"name":55,"role":22,"phone":56,"phoneExt":10,"email":57},"Xun Hu, MD, PhD","020-87608185","hxun@mail.sysu.edu.cn",{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Junbo Ge","Director of Department of Cardiology",[63,65,67],{"name":64,"class":6},"First Affiliated Hospital, Sun Yat-Sen University",{"name":66,"class":6},"Zhongnan Hospital",{"name":68,"class":69},"The 7th People's Hospital of Zhengzhou","UNKNOWN","100640946","impact-of-hyperemic-state-on-angio-imr-performance-100640946",false,"NCT07613996","Impact of Hyperemic State on Angio-IMR Performance","The Impact of Hyperemic State on the Performance of Angiography Derived Indices in Assessing Coronary Microvascular Disease","Inclusion Criteria:\n\n* Stable angina or suspected coronary heart disease.\n* Scheduled for coronary angiography and physiological assessment.\n* Target vessel with stenosis \\\u003C 50% or 50%-90% with fractional flow reserve (FFR) \\> 0.80.\n* Provided informed consent.\n\nExclusion Criteria:\n\n* Hemodynamic instability (acute myocardial infarction, cardiogenic shock, severe arrhythmia).\n* Contraindications to angiography (e.g., end-stage renal disease).\n* Contraindications to adenosine (e.g., severe asthma, high-degree atrial-ventricular block).\n* Life expectancy \\\u003C 1 year or pregnancy.\n* Target vessel unsuitable for wire operation (left main lesion, severe tortuosity) or stenosis \\> 90%.","ALL","18 Years",{"count":80,"type":81},192,"ESTIMATED","1 Day","OBSERVATIONAL","The goal of this observational study is to evaluate the diagnostic performance of angiography-derived microcirculatory indices (Angio-IMR) in assessing patients with stable angina or suspected coronary artery disease. The main questions it aims to answer are:\n\nHow do the numerical values of Angio-IMR from five different software vendors change across three physiological states (resting, sub-hyperemia induced by nitroglycerin, and maximal hyperemia induced by adenosine)? Which physiological state and software algorithm provide the highest diagnostic accuracy (Area Under the Curve, AUC) for diagnosing Coronary Microvascular Disease (CMD) when compared to the gold standard wire-based IMR? Researchers will compare the Angio-IMR results calculated under the three different physiological conditions within the same patient to see how the hyperemic state impacts the performance and consistency of these non-invasive indices.\n\nParticipants will:\n\nUndergo standard-of-care coronary angiography and physiological assessment using a pressure wire for index of microvascular resistance (Wire-IMR) as part of their clinical management.\n\nHave their angiographic images captured at three specific time points: at rest, after intracoronary nitroglycerin, and during adenosine-induced maximal hyperemia.\n\nAllow their de-identified imaging and clinical data to be analyzed by an independent core laboratory using five different Angio-IMR software platforms to evaluate microvascular function.",[86,87],"Coronary Artery Disease","Microvascular Coronary Artery Disease",[89,90,91,92],"Coronary Physiology","Computational Fluid Dynamics","Index of Microcirculatory Resistance","Angiography-Derived Indices","2026-05-21",{"date":95,"type":96},"2026-05-29","ACTUAL",{"date":98,"type":96},"2026-05-04",{"date":100,"type":81},"2026-12-31",{"name":5,"class":6},2]