[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100423256":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":28,"locations":39,"responsibleParty":60,"collaborators":11,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":11,"enrollmentInfo":72,"targetDuration":11,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":11,"overallStatus":42,"whyStopped":11,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Direction Centrale du Service de Santé des Armées","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy individuals","EXPERIMENTAL",null,[13,14],"Procedure: Hyperbaric oxygen therapy","Procedure: Diving simulation",{"label":16,"type":10,"description":11,"interventionNames":17},"Decompression sickness patients",[13],[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"PROCEDURE","Hyperbaric oxygen therapy","Hyperbaric oxygen therapy protocol",[16,9],{"type":20,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Diving simulation","Hyperbaric chamber diving simulation protocol",[9],[29,35],{"name":30,"role":31,"phone":32,"phoneExt":33,"email":34},"Nicolas VALLEE, PhD","CONTACT","483162849","+33","nicolas.vallee@intradef.gouv.fr",{"name":36,"role":31,"phone":37,"phoneExt":33,"email":38},"Céline RAMDANI, MD, PhD","483162844","celine.ramdani@intradef.gouv.fr",[40],{"facility":41,"status":42,"city":43,"state":11,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Hôpital d'Instruction des Armées Sainte-Anne","RECRUITING","Toulon","83800","France","FR",{"type":48,"coordinates":49},"Point",[50,51],5.92836,43.12442,{"lat":51,"lon":50},[54,55,56,58],{"name":30,"role":31,"phone":32,"phoneExt":33,"email":34},{"name":36,"role":31,"phone":37,"phoneExt":33,"email":38},{"name":36,"role":57,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"name":59,"role":57,"phone":11,"phoneExt":11,"email":11},"Sarah RIVES, MD",{"type":61,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100423256","impact-of-hyperoxia-and-involvement-of-the-immune-system-in-diving-accident-100423256",false,"NCT04791488","Impact of Hyperoxia and Involvement of the Immune System in Diving Accident","OXYDIVE","Inclusion Criteria:\n\n* Healthy subject with no contraindications to diving OR patient admitted to the hospital for suspicion of a diving accident OR patient admitted to the hospital for hyperbaric oxygen therapy\n\nExclusion Criteria:\n\n* Contraindication to diving or contraindication to hyperbaric oxygen therapy",true,"ALL","18 Years",{"count":73,"type":74},265,"ESTIMATED","INTERVENTIONAL",[77],"NA","The impact of oxygen therapy in many pathologies has been subject of recent work, arguing both favourable and harmful effects. Consequently, one can wonder about the influence of hyperoxic gas mixture during diving on the genesis of decompression sickness, but also about the systematic application of normobaric and hyperbaric oxygen in case of proven decompression sickness.\n\nIn mammals, normoxic concentrations have been redefined at 20-100 mbars at the extracellular level and below 10 mbars in the mitochondria.\n\nUnder hyperbaric conditions, most of the oxygen being dissolved in blood plasma, a state of hyperoxia is established which escapes the usual delivery and regulation system represented by red blood cells.\n\nThe results of our team's previous work suggest a specific effect of diving on the levels of circulating mitochondrial DNA (mtDNA), suggesting cellular destruction linked to hyperoxia\u002Fhyperbaria. In fact, our studies, carried out on both animals and human divers, have shown that diving accident leads to an increase in mtDNA levels and an immune reaction through the mobilisation of leukocytes.\n\nThe main objective of this study is to compare the influence of oxygen partial pressure levels on the evolution of clinical and biological variables during hyperbaric oxygen therapy sessions in healthy versus injured divers.",[80],"Decompression Sickness","2023-04-27",{"date":83,"type":84},"2023-04-28","ACTUAL",{"date":86,"type":84},"2022-03-30",{"date":88,"type":74},"2028-03-30",{"name":5,"class":6},1]