[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631295":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":28,"locations":38,"responsibleParty":61,"collaborators":18,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":18,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":18,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":41,"whyStopped":18,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Pontificia Universidad Catolica de Chile","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Immersive Virtual Reality During Exercise","EXPERIMENTAL","Participants perform a constant-load submaximal cycling exercise test while exposed to immersive virtual reality (IVR) through a head-mounted display. The exercise intensity is individualized based on a prior incremental cardiopulmonary exercise test. Respiratory effort and ventilatory variables are continuously measured during the exercise protocol.",[13],"Behavioral: Immersive Virtual Reality",{"label":15,"type":16,"description":17,"interventionNames":18},"Exercise Without Virtual Reality (Control)","NO_INTERVENTION","Participants perform the same constant-load submaximal cycling exercise protocol without exposure to immersive virtual reality. Exercise intensity is individualized based on a prior incremental cardiopulmonary exercise test. Respiratory effort and ventilatory variables are continuously measured during the exercise protocol.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Immersive Virtual Reality","Participants are exposed to immersive virtual reality using a head-mounted display during a constant-load submaximal cycling exercise test. The virtual environment provides visual and auditory immersion designed to induce a sense of presence and relaxation. Exercise intensity is individualized based on a prior incremental cardiopulmonary exercise test. The intervention is intended to evaluate the acute effects of immersive virtual reality on respiratory effort, ventilatory responses, and perceived dyspnea during exercise.",[9],[26,27],"Immersive VR","Virtual Reality Exposure",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":18,"email":33},"Gonzalo A Valdivia Lobos, Physiotherapy","CONTACT","+56971367803","gavaldivia@uc.cl",{"name":35,"role":31,"phone":36,"phoneExt":18,"email":37},"Felipe Damiani R., PhD","+56966698823","lfdamiani@uc.cl",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Escuela de Ciencias de la Salud UC. Departamento de Kinesiología.","RECRUITING","Santiago","Santiago Metropolitan","6904411","Chile","CL",{"type":48,"coordinates":49},"Point",[50,51],-70.64827,-33.45694,{"lat":51,"lon":50},[54,56,58],{"name":55,"role":31,"phone":32,"phoneExt":18,"email":33},"Gonzalo A Valdivia, Physiotherapy",{"name":57,"role":31,"phone":36,"phoneExt":18,"email":37},"Felipe Damiani, PhD",{"name":59,"role":60,"phone":18,"phoneExt":18,"email":18},"Benjamin Carrillo, Physiotherapy","SUB_INVESTIGATOR",{"type":62,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100631295","impact-of-immersive-virtual-reality-ivr-on-respiratory-effort-a-pilot-study-in-healthy-adults-100631295",false,"NCT07498816","Impact of Immersive Virtual Reality (IVR) on Respiratory Effort: A Pilot Study in Healthy Adults","Inclusion Criteria:\n\n* Healthy adults aged 18-40 years\n* Ability to perform cycle ergometer exercise testing\n* No known history of cardiovascular, pulmonary, neurological, or metabolic disease\n\nExclusion Criteria:\n\n* Current respiratory symptoms or acute illness\n* Known cardiovascular, pulmonary, neurological, or metabolic disease\n* Use of medications that may affect respiratory or cardiovascular responses to exercise\n* Contraindications to exercise testing according to standard clinical guidelines\n* Pregnancy\n* Inability to tolerate placement of an esophageal balloon catheter\n* Susceptibility to motion sickness or discomfort with immersive virtual reality devices",true,"ALL","18 Years","40 Years",{"count":74,"type":75},10,"ESTIMATED","INTERVENTIONAL",[78],"NA","This pilot randomized crossover study will evaluate the acute effects of immersive virtual reality (IVR) on respiratory effort during submaximal exercise in healthy adults. Dyspnea and increased respiratory effort are influenced not only by mechanical and metabolic factors, but also by emotional and central neural inputs. IVR has shown potential to reduce anxiety, promote relaxation, and modulate physiological responses, but its direct effect on respiratory effort has not been adequately studied.\n\nHealthy adults will complete two experimental exercise sessions: one session with IVR and one session without IVR, in randomized order. In both conditions, participants will perform a 6-minute constant-load cycling test at a submaximal workload individualized from a prior incremental exercise test. Respiratory effort will be assessed continuously using esophageal pressure monitoring. Additional measurements will include ventilatory variables, perceived dyspnea, acute state anxiety, heart rate, oxygen saturation, and heart rate variability.\n\nThe primary aim is to determine whether IVR reduces respiratory effort compared with the control condition. This pilot study is intended to provide physiological evidence on the potential role of IVR as a non-pharmacological strategy to modulate respiratory effort and dyspnea, and to inform future research in clinical populations.",[81,82,83],"Virtual Reality","Respiratory Effort","Exercise",[85,86,87],"immersive virtual reality","breathing effort","inspiratory effort","2026-03-23",{"date":90,"type":91},"2026-03-27","ACTUAL",{"date":93,"type":91},"2025-10-01",{"date":95,"type":75},"2026-12-15",{"name":5,"class":6},1]