[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599415":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":34,"centralContacts":48,"locations":34,"responsibleParty":54,"collaborators":34,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":34,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":34,"maxAge":34,"enrollmentInfo":67,"targetDuration":34,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":85,"whyStopped":34,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":34},{"fullName":5,"class":6},"Minia University","OTHER",[8,15,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"GROUP I","EXPERIMENTAL","treated with nanochitosan and passive ultrasonic activation",[13,14],"Other: Chitosan Nanoparticles Irrigant","Device: ultrasonic activator",{"label":16,"type":10,"description":17,"interventionNames":18},"GROUP II","treated with nanochitosan and laser activation",[13,19],"Device: Diode Laser Activation",{"label":21,"type":10,"description":22,"interventionNames":23},"GROUP III","treated with nano-Aloe Vera and passive ultrasonic activation",[24,14],"Other: aloe vera nanoparticles irrigant",{"label":26,"type":10,"description":27,"interventionNames":28},"GROUP IV","treated with nano-Aloe Vera and laser activation",[24,19],[30,35,39,44],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Chitosan Nanoparticles Irrigant","using Chitosan Nanoparticles irrigant as a final irrigation solution.",[9,16],null,{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"aloe vera nanoparticles irrigant","using Aloe Vera Nanoparticles irrigant as a final irrigation solution.",[21,26],{"type":40,"name":41,"description":42,"armGroupLabels":43,"otherNames":34},"DEVICE","Diode Laser Activation","activation of nanoparticles irrigants using diode laser",[16,26],{"type":40,"name":45,"description":46,"armGroupLabels":47,"otherNames":34},"ultrasonic activator","activation of nanoparticles irrigants using ultrasonic activator",[9,21],[49],{"name":50,"role":51,"phone":52,"phoneExt":34,"email":53},"Rabee Ibrahaim Alhabibi","CONTACT","+201018836570","rabieibrahaim@gmail.com",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"PRINCIPAL_INVESTIGATOR","Rabee Ibrahaim Ismail Alhabibi","Rabee Alhabibi","100599415","impact-of-integrating-two-nano-based-irrigants-with-two-activation-techniques-in-treatment-of-teeth-with-acute-pulpitis-on-postoperative-pain-and-flare-up-incidence-100599415",false,"NCT07084194","Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence","Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence: A Randomized Clinical Study","Inclusion Criteria:\n\n* Age 18-60 (adults only)\n* multiple-rooted with multiple root canal.\n* Permanent teeth with mature apex and complete root formation.\n* Without root caries.\n* Tooth must be restorable.\n* Without anatomical abnormalities such as fusion.\n* Healthy patient category I according to ASA.\n* Vital tooth, with acute irreversible pulpitis and without peri-apical periodontitis.\n* No periapical radiolucency.\n* Consent Patients for who consent to participate and attend follow-up appointments.\n\nExclusion Criteria:\n\n* single root canals or double root.\n* Root canal calcifications.\n* Root resorption or fracture.\n* Previously root canal treated teeth.\n* immunocompromised patients.\n* Pregnant females\n* Patients with systemic diseases as diabetic or hypertension patients.\n* Patients with facial swelling.\n* patients who use analgesics or antibiotics within 48-72 hours.\n* Allergy to any materials used (e.g., irrigants or anesthetics).\n* psychiatric illness\n* Teeth that are not indicated for endodontic treatment: bad oral hygiene, mobile teeth, or recessed teeth.\n* Previously endodontically treated teeth.\n* Teeth with sinus tract.",true,"ALL",{"count":68,"type":69},64,"ESTIMATED","INTERVENTIONAL",[72],"NA","This study aimed to evaluate and compare impact of integrating passive ultrasonic activation and laser activation with nano-chitosan and aloe vera in terms of postoperative pain and flare-up incidence in a randomized clinical trial.",[75,76,77],"Postoperative Pain","Flare up","Flare Up, Symptom",[79,80,81,82,83,84],"postoperative pain","flare up","nano-technology","irrigation","chitosan","aloe-vera","NOT_YET_RECRUITING","2025-07-16",{"date":88,"type":89},"2025-07-24","ACTUAL",{"date":91,"type":69},"2025-09-10",{"date":93,"type":69},"2026-08-10",{"name":5,"class":6}]