[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617905":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":36,"collaborators":10,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":10,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":10,"enrollmentInfo":49,"targetDuration":10,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":60,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Hemodynamic Instability Group",null,"Patients who exhibit intraoperative hemodynamic instability, defined as Mean Arterial Pressure (MAP) \\\u003C 65 mmHg for \\>5 minutes continuously, or requiring vasopressor\u002Finotropic support to maintain MAP.",{"label":13,"type":10,"description":14,"interventionNames":10},"Hemodynamically Stable Group","Patients who maintain intraoperative hemodynamic stability without significant hypotension episodes (MAP \\> 65 mmHg) or vasopressor requirement beyond baseline anesthesia induction.",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Osman Uzundere, M.D.","CONTACT","+905330206362","osmanuzundere@gmail.com",[22],{"facility":23,"status":24,"city":25,"state":25,"zip":26,"country":27,"countryCode":10,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Gazi Yaşargil Training and Research Hospital","RECRUITING","Diyarbakır","21070","Turkey (Türkiye)",{"type":29,"coordinates":30},"Point",[31,32],40.21721,37.91363,{"lat":32,"lon":31},[35],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Osman Uzundere","Principal Investigator","100617905","impact-of-intraoperative-hemodynamic-instability-on-outcomes-in-cardiac-surgery-100617905",false,"NCT07324694","Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery","Impact of Intraoperative Hemodynamic Instability on Postoperative Major Adverse Events in Cardiac Surgery Patients: A Prospective Cohort Study","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Scheduled for elective cardiac surgery (CABG, Valve replacement\u002Frepair, or combined procedures).\n* Surgery performed under cardiopulmonary bypass (CPB).\n* Preoperative sinus rhythm.\n* Signed informed consent form.\n\nExclusion Criteria:\n\n* Emergency or salvage surgery.\n* Off-pump coronary artery bypass grafting.\n* Preoperative mechanical circulatory support (IABP, ECMO) requirement.\n* Pre-existing chronic renal failure requiring dialysis (HD\u002FPD).\n* Pre-existing cognitive impairment, dementia, or history of psychiatric disorders affecting cooperation.\n* Pregnancy.","ALL","18 Years",{"count":50,"type":51},230,"ESTIMATED","OBSERVATIONAL","Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear. This prospective cohort study aims to evaluate the association between intraoperative hemodynamic instability (defined as MAP \\\u003C 65 mmHg or vasopressor requirement) and major postoperative complications (Delirium, Acute Kidney Injury, Stroke, or Mortality) in adult patients undergoing elective cardiac surgery with cardiopulmonary bypass.",[55,56,57,58,59],"Cardiac Surgery","Intraoperative Hemodynamic Instability","Postoperative Complication","Acute Kidney Injury","Postoperative Delirium (POD)",[61,62,63,64],"Intraoperative Hypotension","Cardiopulmonary Bypass","Mean Arterial Pressure","Cohort Study","2026-01-09",{"date":67,"type":68},"2026-01-12","ACTUAL",{"date":70,"type":68},"2025-04-26",{"date":72,"type":51},"2026-02-05",{"name":5,"class":6},1]