[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564926":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":10,"centralContacts":32,"locations":41,"responsibleParty":68,"collaborators":70,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":10,"studyType":88,"phases":10,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Hemodialysis patients",null,"Subjects with advanced chronic kidney disease requiring thrice-weekly hemodialysis",[13,14],"Biological: Influenza vaccination","Biological: SARS-CoV-2 vaccine",{"label":16,"type":10,"description":17,"interventionNames":18},"Peritoneal dialysis patients","Subjects with advanced chronic kidney disease on peritoneal dialysis",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Healthy controls","Subjects without a prior history of chronic kidney disease",[13,14],[24,29],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"BIOLOGICAL","Influenza vaccination","Single-dose",[20,9,16],{"type":25,"name":30,"description":27,"armGroupLabels":31,"otherNames":10},"SARS-CoV-2 vaccine",[20,9,16],[33,38],{"name":34,"role":35,"phone":36,"phoneExt":10,"email":37},"Manuel A Podesta', MD, PhD","CONTACT","0039 0255034568","manuel.podesta@policlinico.mi.it",{"name":39,"role":35,"phone":10,"phoneExt":10,"email":40},"Giuseppe Castellano, MD, PhD","giuseppe.castellano@policlinico.mi.it",[42,55,62],{"facility":43,"status":44,"city":45,"state":10,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":10},"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","RECRUITING","Milan","20122","Italy","IT",{"type":50,"coordinates":51},"Point",[52,53],12.59836,42.78235,{"lat":53,"lon":52},{"facility":56,"status":57,"city":45,"state":10,"zip":58,"country":47,"countryCode":48,"cosmosGeoPoint":59,"geoPoint":61,"contacts":10},"ASST Santi Paolo e Carlo","NOT_YET_RECRUITING","20142",{"type":50,"coordinates":60},[52,53],{"lat":53,"lon":52},{"facility":63,"status":57,"city":45,"state":10,"zip":64,"country":47,"countryCode":48,"cosmosGeoPoint":65,"geoPoint":67,"contacts":10},"ASST Fatebenefratelli Sacco","20157",{"type":50,"coordinates":66},[52,53],{"lat":53,"lon":52},{"type":69,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[71],{"name":72,"class":73},"Fondazione Cariplo","UNKNOWN","100564926","impact-of-kidney-failure-on-the-regulation-of-humoral-response-to-vaccination-100564926",false,"NCT06635525","Impact Of Kidney Failure On The Regulation Of Humoral Response To Vaccination","Tfh-CKD","Inclusion Criteria:\n\n* Age between 18 and 70 years\n* Patients undergoing thrice-weekly hemodialysis \u002F peritoneal dialysis for at least 3 months OR healthy individuals without a history of renal insufficiency\n* Subjects eligible to receive a seasonal influenza vaccine\n* Signed informed consent for participation in the study\n\nExclusion Criteria:\n\n* Recent influenza infection (clinically resolved less than 3 months ago).\n* Administration of immunosuppressive drugs in the two weeks prior to vaccination.\n* Administration of another vaccine in the three weeks prior to enrollment (co-administration of other vaccines with those under study does not contraindicate participation).\n* Systemic infection clinically resolved less than two weeks before enrollment.",true,"ALL","18 Years","70 Years",{"count":86,"type":87},146,"ESTIMATED","OBSERVATIONAL","The aim of this observational study is to determine if and how kidney failure affects the development of protective immune responses following vaccination in patients on chronic dialysis.\n\nResearchers will compare the effectiveness of the influenza vaccine in inducing protective antibodies between hemodialysis patients and subjects without chronic kidney disease.\n\nParticipants will:\n\n* Be enrolled at the time of influenza vaccination\n* Visit the clinic at 7, 14, 30, 60, and 120 days after vaccination\n* Be asked to provide relevant clinical information and a blood sample at each visit",[91,92],"Chronic Kidney Disease Requiring Chronic Dialysis","Vaccine Response",[94,95,96,97,98,99],"Vaccine","Influenza","Chronic Kidney Disease","Hemodialysis","Peritoneal dialysis","Humoral Response","2026-03-25",{"date":102,"type":103},"2026-03-30","ACTUAL",{"date":105,"type":103},"2024-10-16",{"date":107,"type":87},"2026-07",{"name":5,"class":6},3]