[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600289":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":56,"collaborators":12,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":12,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":12,"enrollmentInfo":68,"targetDuration":12,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":81,"overallStatus":36,"whyStopped":12,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","NO_INTERVENTION","Sham laser will be applied instead of the low-level laser.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Intervention","EXPERIMENTAL","Low-level lase therapy will be applied at tooth extraction sites.",[18],"Other: Low-level laser therapy",[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":12},"Low-level laser therapy","The low-level laser applications will be made on the same day as the standard of care treatment (day 1), and then day 3, and day 7 by a study team member who is trained in the use of the laser device.\n\nThe laser photobiostimulation will be applied using LightWalker® laser (FOTONA), with following settings, Nd:YAG laser 1064 nm, MSP modality (pulse duration), 0.5 W (power), 10 Hz (frequency), 1 min\u002F 1 cm2 spot using Genova handpiece from buccal, lingual, and occlusal aspects. The Genova handpiece will be placed 1 cm away from gingival tissue.\n\nParticipants and operators will wear glasses to protect their eyes from laser beam in all sessions.",[14],[25],{"name":26,"affiliation":5,"role":27},"Pinar Emecen-Huja","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":12,"email":32},"CONTACT","(843) 792-5688","emecenh@musc.edu",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"MUSC College of Dental Medicine, Graduate Periodontics Clinic","RECRUITING","Charleston","South Carolina","29425","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-79.93275,32.77632,{"lat":46,"lon":45},[49,53],{"name":50,"role":30,"phone":51,"phoneExt":12,"email":52},"Joe Gambacorta, DDS","843-876-7645","gambacor@musc.edu",{"name":54,"role":30,"phone":12,"phoneExt":12,"email":55},"Ben (Hua-Hong) Chien, DDS","chienh@musc.edu",{"type":57,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100600289","impact-of-ndyag-laser-photobiostimulation-on-healing-of-gingiva-100600289",false,"NCT07095556","Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva","Impact of Nd: YAG Laser Photobiostimulation on Healing of Gingiva Following Tooth Extraction and Alveolar Ridge Preservation","Inclusion Criteria:\n\n* Participants who are ≥ 18 years old,\n* Patients who are scheduled for the treatment of tooth extraction and alveolar ridge preservation (ARP)\n* No contraindications for tooth extraction and alveolar ridge preservation based on electronic health records.\n* Participants who can express the level of pain\n* Participants who self-report \"not pregnant\"\n\nExclusion Criteria:\n\n* Untreated periodontal disease\n* Acute infection of the teeth\n* Use of antibiotics within the last three months.\n* Pregnant or lactating women\n* Use of bisphosphonates based on EHR\n* Alveolar bone defects occurred or were detected during tooth extraction",true,"ALL","18 Years",{"count":69,"type":70},39,"ESTIMATED","INTERVENTIONAL",[73],"NA","The intervention in this study is to determine whether multiple applications of photobiostimulation with Nd-YAG laser improve wound healing following tooth extraction and alveolar ridge preservation. Investigators plan to assess the impact of laser treatment on wound healing by measuring salivary biomarkers, gingival wound size and surveying for the use of pain reduction and patient satisfaction. The intervention group will receive extraction and alveolar ridge preservation with Nd-YAG laser photobiostimulation on days 1, 3, and 7 following extraction and socket preservation, while the control group will receive the standard of care extraction and alveolar ridge preservation without the laser",[76,77,78,79,80],"Wound Healing and Prevention","Oral Inflammation","Photobiomodulation","Post-operative Pain Management","Tooth Extraction Site Healing",[82,83,84,85,86],"Inflammation","Periodontal Disease","low-level laser therapy","gingival healing","Post-operative pain","2025-11-07",{"date":89,"type":90},"2025-11-12","ACTUAL",{"date":92,"type":90},"2025-11-05",{"date":94,"type":70},"2027-04-30",{"name":5,"class":6},1]