[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609044":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":56,"collaborators":25,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":25,"eligibilityCriteria":65,"healthyVolunteers":62,"sex":66,"minAge":67,"maxAge":25,"enrollmentInfo":68,"targetDuration":25,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Paravertebral Block","ACTIVE_COMPARATOR","Paravertebral block at preop",[13],"Procedure: Paravertebral block (single injection)",{"label":15,"type":16,"description":17,"interventionNames":18},"Pectoral Block","EXPERIMENTAL","Pectoral block at preop",[19],"Procedure: Pectoral block",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Paravertebral block (single injection)",[9],null,{"type":22,"name":27,"description":17,"armGroupLabels":28,"otherNames":25},"Pectoral block",[15],[30],{"name":31,"affiliation":5,"role":32},"Amy Colwell, M.D.","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Cathleen Huang, D.O.","CONTACT","617-726-2284","CHUANG24@DFCI.HARVARD.EDU",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-71.05977,42.35843,{"lat":51,"lon":50},[54,55],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},{"name":31,"role":32,"phone":25,"phoneExt":25,"email":25},{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Amy Colwell","Sponsor-Investigator","100609044","impact-of-pectoral-versus-paravertebral-blocks-on-pain-and-physical-well-being-in-implant-based-breast-reconstruction-100609044",false,"NCT07209436","Impact of Pectoral Versus Paravertebral Blocks on Pain and Physical Well-Being in Implant-Based Breast Reconstruction","Inclusion Criteria:\n\n* Adult patient 18 years or older\n* Scheduled for unilateral or bilateral immediate implant-based breast reconstruction\n* Therapeutic or prophylactic indication\n* Patient understands the study procedures and objectives and is willing to participate\n* Patient willing to and capable of providing informed consent\n\nExclusion Criteria:\n\n* Delayed breast reconstruction\n* Allergy or contraindication to local anesthetics (PVB or PECS blocks)\n* History of radiation therapy\n* Planned sedation or general anesthesia protocol variation\n* Morbid obesity as defined as a BMI greater than 40 kg\u002Fm2\n* Renal insufficiency\n* Chronic pain syndrome or central sensitization disorders (e.g., fibromyalgia, CRPS)\n* Use of implanted pain devices or neuromodulators\n* Pre-existing neurological deficits in the surgical field\n* Current chronic opioid use (daily use within the 2 weeks before surgery and duration of use greater than 4 weeks)\n* Use of any nerve medications in the past 6 months, including antiepileptic medications (gabapentin, carbamazepine)\n* History of drug or alcohol abuse or habitual alcohol intake greater than two standard drinks per day (e.g., two beers, two glasses of wine, or two mixed drinks)\n* Any comorbidity that results in moderate or severe functional limitation, inability to communicate with the investigators or hospital staff\n* History of a psychiatric disorder which would interfere with the study procedure\n* Incarceration\n* Any issue that at the discretion of the investigator would contraindicate the subject's participation\n* Inability to understand the procedures and objectives of the study\n* Inability to or unwilling to provide informed consent","ALL","18 Years",{"count":69,"type":70},212,"ESTIMATED","INTERVENTIONAL",[73],"NA","The broad aim of this study is to compare the effectiveness of paravertebral and pectoral blocks on pain and physical well-being of patients undergoing immediate implant-based breast reconstruction.",[76],"Breast Reconstruction",[76,78],"Breast cancer","2026-01-20",{"date":81,"type":82},"2026-01-22","ACTUAL",{"date":84,"type":82},"2025-11-19",{"date":86,"type":70},"2028-06",{"name":58,"class":6},1]