[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591306":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":31,"responsibleParty":56,"collaborators":20,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":20,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":20,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Postgraduate Institute of Dental Sciences Rohtak","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Periodontitis","EXPERIMENTAL","Stage II\u002FIII Periodontitis",[13],"Procedure: Sub-gingival instrumentation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Sub-gingival instrumentation","All patients will undergo dental biofilm control through patient motivation, oral hygiene instructions and supragingival professional mechanical plaque removal followed by sub-gingival instrumentation.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Rajinder K Sharma, MDS","CONTACT","+919416358222","rksharmamds@yahoo.in",{"name":28,"role":24,"phone":29,"phoneExt":20,"email":30},"Gaytri, BDS","+919991092061","gaytrilalit2@gmail.com",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"PGIDS","RECRUITING","Rohtak","Haryana","124001","India","IN",{"type":41,"coordinates":42},"Point",[43,44],76.58917,28.89447,{"lat":44,"lon":43},[47,48,52,54],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"name":49,"role":24,"phone":50,"phoneExt":20,"email":51},"Sanjay Tewari, MDS","01262-297876","principal.pgids@uhsr.ac.in",{"name":23,"role":53,"phone":20,"phoneExt":20,"email":20},"SUB_INVESTIGATOR",{"name":28,"role":55,"phone":20,"phoneExt":20,"email":20},"PRINCIPAL_INVESTIGATOR",{"type":57,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100591306","impact-of-periodontal-inflammation-on-allostatic-load-100591306",false,"NCT06978712","Impact of Periodontal Inflammation on Allostatic Load","Impact of Subgingival Instrumentation on Allostatic Load in Periodontitis","Inclusion Criteria:\n\n* Patients with age group 30-50 years diagnosed with generalized periodontitis.\n* Presence of minimum 20 teeth excluding third molars.\n\nExclusion Criteria:\n\n* Periodontal treatment within last 6 months\n* History of antibiotic use within the previous 3 months\n* History of use of steroid, immunosuppressive and psychiatric drugs\n* Pregnant and lactating women\n* History of substance abuse","ALL","30 Years","50 Years",{"count":69,"type":70},112,"ESTIMATED","INTERVENTIONAL",[73],"NA","Periodontitis is a prevalent global health issue that contributes to systemic inflammation and is closely linked to stress as a risk factor. Both conditions have been investigated for bidirectional relationship. However, the results are inconsistent, and the mechanistic links remain unclear. Allostatic load, which measures the cumulative biological effects of stress, may be relevant in elucidating this connection. Inconsistent results have been reported in previous studies exploring the association between periodontitis and individual biomarkers of allostatic load. Furthermore, none of these studies has taken into consideration staging and grading of periodontitis. Additionally, while periodontal treatment has been shown to reduce both local and systemic inflammation, its effect on allostatic load remains unexplored till date. This study aims to fill these gaps by evaluating the relationship between these parameters of periodontitis and allostatic load. Evaluation of impact of subgingival instrumentation on allostatic load may further provide insights into the broader systemic benefits of periodontal interventions.",[76,77],"Allostatic Load","Periodontitis, Chronic",[79,80,81],"periodontitis","inflammation","allostatic load","2026-05-21",{"date":84,"type":85},"2026-05-26","ACTUAL",{"date":87,"type":85},"2025-06-10",{"date":89,"type":70},"2026-12-01",{"name":5,"class":6},1]