[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626001":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":11,"centralContacts":50,"locations":56,"responsibleParty":74,"collaborators":11,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":11,"enrollmentInfo":85,"targetDuration":11,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":99,"whyStopped":11,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"University Hospital, Montpellier","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Elderly subjects with a femoral neck fracture or severe hip osteoarthritis requiring surgery","EXPERIMENTAL",null,[13,14,15,16,17,18,19],"Procedure: Total hip replacement","Biological: Blood sampling","Biological: Muscle biopsies","Biological: Collection of joint samples derived from surgical waste","Radiation: DXA","Other: MRI","Other: Handgrip strength test",[21,26,31,35,38,43,46],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":11},"PROCEDURE","Total hip replacement","Hip replacement is a surgical procedure performed as part of routine care for patients with a fracture of the upper end of the femur or severe osteoarthritis of the hip.",[9],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":11},"BIOLOGICAL","Blood sampling","Four heparinized tubes of 5 ml of blood will be collected from each patient at inclusion. All blood samples will be stored in a biobank for subsequent analyses targeting biomarkers potentially associated with sarcopenia and muscle regeneration.",[9],{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":11},"Muscle biopsies","Performed during hip arthroplasty",[9],{"type":27,"name":36,"description":33,"armGroupLabels":37,"otherNames":11},"Collection of joint samples derived from surgical waste",[9],{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":11},"RADIATION","DXA","Within 15 days following the surgical procedure, during hospitalization\u002Frehabilitation",[9],{"type":6,"name":44,"description":41,"armGroupLabels":45,"otherNames":11},"MRI",[9],{"type":6,"name":47,"description":48,"armGroupLabels":49,"otherNames":11},"Handgrip strength test","Measurement of handgrip strength using a hand dynamometer",[9],[51],{"name":52,"role":53,"phone":54,"phoneExt":11,"email":55},"Jean Baptiste ROBIAUD, Assistant head physician","CONTACT","+33629184092","jbrobiaud@gmail.com",[57],{"facility":58,"status":11,"city":59,"state":11,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"University Hospital","Montpellier","34090","France","FR",{"type":64,"coordinates":65},"Point",[66,67],3.87635,43.61093,{"lat":67,"lon":66},[70,72],{"name":71,"role":53,"phone":54,"phoneExt":11,"email":55},"Jean Baptiste Robiaud, Assistant head physician",{"name":52,"role":73,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"type":75,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100626001","impact-of-pre-operative-sarcopenia-on-functional-recovery-after-hip-arthroplasty-in-older-adults-100626001",false,"NCT07429955","Impact of Pre-operative Sarcopenia on Functional Recovery After Hip Arthroplasty in Older Adults","HIP-REGEN","Inclusion Criteria:\n\n\\- Elderly subjects undergoing surgical hip replacement for fracture of the upper end of the femur or severe hip osteoarthritis.\n\nExclusion Criteria for both groups :\n\n* Contraindications to MRI : pacemaker, metallic implants.\n* Presence of a lower-limb prosthesis on the contralateral side to the surgery that may interfere with quadriceps mass measurements.\n* Progressive high-grade neoplasia.\n* Documented major cognitive disorders\n* Under legal protection measures (guardianship, conservatorship, or curatorship).\n* Subjects not affiliated with or not covered by a social security system.\n* Participation in another ongoing study with an active exclusion period.\n\nExclusion criteria - Fracture group :\n\n* Fracture with a suspicion of underlying neoplasia.\n* Placement of a lower-limb prosthesis on the surgical side within the last 12 months.\n* Inability to walk with or without human\u002Ftechnical assistance prior to fracture.\n\nExclusion criteria - Hip osteoarthritis group :\n\n\\- Active inflammatory joint disease (rheumatoid arthritis, spondyloarthritis).","ALL","75 Years",{"count":86,"type":87},20,"ESTIMATED","INTERVENTIONAL",[90],"NA","This single-centre, exploratory study at Montpellier University Hospital will investigate whether having low muscle mass and strength before hip-replacement surgery, a condition called sarcopenia, impact the return to everyday independence in people aged 75 years or older. About 20 volunteers, scheduled for surgery because of a recent femoral-neck fracture or severe arthritis that no longer responds to usual care, will give consent, answer brief health questionnaires, attempt simple walking and chair-rise tests if possible, and provide a small blood sample. While they are already under anaesthesia for their planned operation, the surgical team will take a tiny muscle sample through the same incision, so no extra cuts are needed. During the hospital stay or shortly after discharge, each participant will have a painless MRI scan of the thigh muscles and a very-low-dose bone scan (DXA) to measure muscle and bone health. The research team will then telephone participants at 3 and 6 months to ask about daily activities, walking ability, and any complications. The study lasts about six months for each person and does not alter their usual medical or rehabilitation care. Potential benefits include close follow-up, personalised feedback on muscle and bone results, and helping doctors learn whether pre-surgery muscle weakness predicts slower recovery-information that could guide future, more personalised exercise and nutrition programs. Extra study procedures carry only minimal risks: a routine blood draw, scans with none (MRI) or very little (DXA) radiation, and a muscle biopsy taken during surgery. Taking part is entirely voluntary, and participants may withdraw at any time without affecting their current or future care. The whole project will run for 18 months.",[93,94,95],"Sarcopenia in Elderly","Osteoarthritis (OA)","Hip Fracture Surgeries",[93,94,95,97,98],"Functional Recovery","Rehabilitation","NOT_YET_RECRUITING","2026-02-17",{"date":102,"type":103},"2026-02-24","ACTUAL",{"date":105,"type":87},"2026-02",{"date":107,"type":87},"2027-08",{"name":5,"class":6},1]