[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585481":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":38,"collaborators":42,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":71,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"IRCCS Ospedale San Raffaele","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"T-TEER",null,"Adult patients, able to sign the Informed Consent Form, with TR ≥ severe who will be treated with T-TEER",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Clinical Trial Coordinator","CONTACT","+39 0226435316","schiavi.davide@hsr.it",[19],{"facility":5,"status":10,"city":20,"state":21,"zip":22,"country":21,"countryCode":23,"cosmosGeoPoint":24,"geoPoint":29,"contacts":30},"Milan","Italy","20132","IT",{"type":25,"coordinates":26},"Point",[27,28],12.59836,42.78235,{"lat":28,"lon":27},[31,33,36],{"name":14,"role":15,"phone":32,"phoneExt":10,"email":17},"+390226435316",{"name":34,"role":35,"phone":10,"phoneExt":10,"email":10},"Francesco Maisano, Professor","PRINCIPAL_INVESTIGATOR",{"name":37,"role":35,"phone":10,"phoneExt":10,"email":10},"Silvio Danese, Professor",{"type":39,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Francesco Maisano","Head of Cardiac Surgery Department; Director of the Heart Valve Center",[43,44],{"name":5,"class":6},{"name":45,"class":46},"Abbott","INDUSTRY","100585481","impact-of-severe-tricuspid-regurgitation-correction-on-gut-microbiota-and-gastrointestinal-function-100585481",false,"NCT06902922","Impact of Severe Tricuspid Regurgitation Correction on Gut Microbiota and Gastrointestinal Function","Tri-GuM","Inclusion Criteria:\n\n* Adult patients, able to sign the Informed Consent Form, admitted to OSR Heart Valve Center with TR ≥ severe treated with T-TEER.\n\nExclusion Criteria:\n\n* Concomitant ≥ severe MR. Such patients may be treated with M-TEER and be re-evaluated after 3 months: if TR is ≥ severe and MR is ≤ moderate the patient may then be enrolled.\n* Surgical candidates\n* Recent \\\u003C 6 months cardiac coronary or structural procedure\n* CAD requiring intervention\n* other valvular disease \\> moderate\n* Treatment with transcatheter tricuspid replacement\n* Age \\\u003C18 years\n* Inability or unwillingness to sign informed consent\n* Kidney dialysis\n* Acute infection\n* Inflammatory bowel diseases\n* Gastrointestinal diseases\n* Previous gastrointestinal surgery\n* Active cancer\n* Active autoimmune or inflammatory diseases\n* Treatments with antibiotics or probiotics within one month\n* Emergency procedures\n* Patients enrolled in interventional studies that may confound study results","ALL","18 Years",{"count":57,"type":58},150,"ESTIMATED","OBSERVATIONAL","Tricuspid regurgitation (TR) is gaining increasing attention within the cardiological community due to its poor prognosis, challenging clinical presentation and difficult treatment.\n\nTR causes decreased forward cardiac output and increased intravascular pressure upstream, which lead to peripheral oedema, ascites, hepatic congestion and kidney failure.\n\nThe microbiota is also getting increasing attention and changes in microbiota have been already associated with cardiovascular disease.\n\nThe impact of hemodynamic effects of TR on the gut microbiota however is still unknown.\n\nPatients affected by TR frequently complain abdominal distension and anorexia. We hypothesize that, due to increased venous congestion, TR may induce impaired gut function with modification in the microbiota and that TR correction may induce reverse changes.\n\nThis study will enroll patients treated with Transcatheter Tricuspid Edge-to-Edge Repair (T-TEER) at the Valve Center of San Raffaele Hospital due to severe TR.\n\nIn addition to the standard of care, before T-TEER, for all patients 2 additional blood samples, 1 urine and 1 fecal sample will be collected.\n\n3 months after the procedure, all patients will be re-assessed at the Valve Center outpatient clinic as standard of care. At this stage for all patients 2 blood samples, 1 urine and 1 fecal sample will be collected again for the purpose of the study. The microbiota metabolites of patients after 3 months from the procedure will be compared to those at baseline according to the degrees of residual TR.\n\nTo assess the reproducibility of the microbiota results and to explore an intrinsic short-term variation in microbiome composition within single patients, a subgroup of 30 patients will undergo a low intervention substudy repeating the measurements (2 blood, 1 urine and 1 fecal) within 10 days, both at baseline and at follow-up.",[62],"Tricuspid Regurgitation (TR)",[64,65,66,67,68,69,70,9],"tricuspid regurgitation","gut microbiota","gastrointestinal","heart","heart valve disease","tricuspid valve disease","transcatheter","NOT_YET_RECRUITING","2025-03-24",{"date":74,"type":75},"2025-03-30","ACTUAL",{"date":77,"type":58},"2025-03-31",{"date":79,"type":58},"2027-09-30",{"name":40,"class":6},1]