[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615329":3},{"organization":4,"armGroups":7,"interventions":34,"overallOfficials":40,"centralContacts":45,"locations":10,"responsibleParty":56,"collaborators":10,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":10,"studyType":73,"phases":10,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":84,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":10},{"fullName":5,"class":6},"Institut Pasteur","INDUSTRY",[8,14,18,22,26,30],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy - Pregnant women",null,"Adult woman, not affected by Hidradenitis Suppurativa, pregnant in her third trimester",[13],"Procedure: Blood sample, skin microbiota and biopsy",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy - Non-pregnant women","Adult woman, not affected by Hidradenitis Suppurativa",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Healthy - Men","Adult men, not affected by Hidradenitis Suppurativa",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Hidradenitis suppurativa - Pregnant women","Adult woman, affected by Hidradenitis Suppurativa, pregnant in her third trimester",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"Hidradenitis suppurativa - Non-pregnant women","Adult woman, affected by Hidradenitis Suppurativa",[13],{"label":31,"type":10,"description":32,"interventionNames":33},"Hidradenitis suppurativa - Men","Adult men, affected by Hidradenitis Suppurativa",[13],[35],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":10},"PROCEDURE","Blood sample, skin microbiota and biopsy","Blood sample (maximum 40mL) Skin microbiota (collection of cells from the skin surface using a swab (non-invasive) Skin biopsy, in hormone-dependent areas and\u002For in a non-hormone-dependent areas",[19,15,9,31,27,23],[41],{"name":42,"affiliation":43,"role":44},"Bénédicte OULES, MD-PhD","Assistance Publique - Hôpitaux de Paris","PRINCIPAL_INVESTIGATOR",[46,52],{"name":47,"role":48,"phone":49,"phoneExt":50,"email":51},"Clarisse GANIER, PhD","CONTACT","0145688767","+33","clarisse.ganier@pasteur.fr",{"name":53,"role":48,"phone":54,"phoneExt":50,"email":55},"Julia ABAD","0140669760","julia.abad@pasteur.fr",{"type":57,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100615329","impact-of-sex-hormones-on-human-skin-immunity-in-health-and-hidradenitis-suppurativa-siap-100615329",false,"NCT07291193","Impact of Sex Hormones on Human Skin Immunity in Health and Hidradenitis Suppurativa (SIAP)","Impact of Sex Hormones on Human Skin Immunity in Health and Hidradenitis Suppurativa","SIAP","Inclusion Criteria:\n\n* Common criteria :\n* Subject\\>18 years and \\\u003C45 years,\n* Written informed consent of the subject,\n* Subject affiliated to the Assurance Maladie (French Health System) except Aide Médicale d'Etat (French State Medical Aid),\n* Subject agrees that genomic analyses may be carried out on the samples\n* Specific criteria :\n* For pregnant women:Third trimester of pregnancy (between 29-37 weeks of amenorrhea).\n* For HS subjects: Subject with hidradenitis suppurativa lesions at the sampling sites.\n\nExclusion Criteria:\n\n* Common criteria :\n* Subject immunocompromised,\n* Subject under legal protection (guardianship or curatorship),\n* Subject is unable to provide informed consent and to comply with the study requirements due to geographical, social, or psychiatric reasons,\n* Subject in other research whose procedures may influence the immune system,\n* Contraindication to any of medications listed in section 5.1 (antiseptic and local anesthetic used for biopsy(ies)),\n* Subject whose health condition does not permit participation in study procedures.\n* Specific criteria :\n* For no HS subjects : Scarred skin at the biopsy site, Subject with pre-existing and\u002For still active inflammatory skin conditions, Subject experiencing early menopause (women) or andropause (men).",true,"ALL","18 Years","45 Years",{"count":71,"type":72},240,"ESTIMATED","OBSERVATIONAL","Sex hormones are major regulators of skin immunity. Pregnancy represents a unique physiological state of profound hormonal remodeling. In late pregnancy, maternal levels of estrogens, progesterone, and other hormones increase dramatically, offering an unparalleled model to study the impact of sex hormones on skin immunity. Hidradenitis suppurativa (HS) provides a clinically relevant model to examine how sex hormones modulate skin inflammation.",[76],"Skin Immunity",[78,79,80,81,82,83],"Pregnancy","Maternal Immunity","Skin","Hormones","Single Cell","Spatial-Omics","NOT_YET_RECRUITING","2026-01-08",{"date":87,"type":88},"2026-01-09","ACTUAL",{"date":90,"type":72},"2026-01",{"date":92,"type":72},"2031-03",{"name":5,"class":6}]