[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583198":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":38,"locations":48,"responsibleParty":67,"collaborators":71,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":30,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":30,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":104,"whyStopped":30,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"Purdue University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Soluble Arabinoxylan","EXPERIMENTAL","Participants in this arm will receive soluble arabinoxylan for 3 consecutive weeks.",[13],"Dietary Supplement: Soluble Arabinoxylan",{"label":15,"type":10,"description":16,"interventionNames":17},"Rice Bran","Participants in this arm will consume rice bran fiber for 3 consecutive weeks.",[18],"Dietary Supplement: Rice Bran",{"label":20,"type":21,"description":22,"interventionNames":23},"Maltodextrin","PLACEBO_COMPARATOR","Participants in this arm will consume maltodextrin for 3 consecutive weeks.",[24],"Dietary Supplement: Maltodextrin (Placebo)",[26,31,34],{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"DIETARY_SUPPLEMENT","10 grams of soluble arabinoxylan diluted in 200 mL of water, twice daily for 3 consecutive weeks.",[9],null,{"type":27,"name":15,"description":32,"armGroupLabels":33,"otherNames":30},"10 grams of rice bran fiber diluted in 200 mL of water, twice daily for 3 consecutive weeks.",[15],{"type":27,"name":35,"description":36,"armGroupLabels":37,"otherNames":30},"Maltodextrin (Placebo)","10 grams of maltodextrin diluted in 200 mL of water, twice daily for 3 consecutive weeks.",[20],[39,44],{"name":40,"role":41,"phone":42,"phoneExt":30,"email":43},"Bruce R Hamaker, Ph.D.","CONTACT","765-494-5668","hamakerb@purdue.edu",{"name":45,"role":41,"phone":46,"phoneExt":30,"email":47},"Mirian A de Campos Costa, Ph.D.","765-496-3802","decampos@purdue.edu",[49],{"facility":50,"status":30,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Clinical Research Center at Purdue University","West Lafayette","Indiana","47907","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-86.90807,40.42587,{"lat":60,"lon":59},[63],{"name":64,"role":41,"phone":65,"phoneExt":30,"email":66},"Robin L Rhine","765-494-6275","rrhine@purdue.edu",{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Bruce R. Hamaker","Professor",[72],{"name":73,"class":74},"Rural Development Administration (RDA) of the Republic of Korea","UNKNOWN","100583198","impact-of-soluble-arabinoxylan-and-rice-bran-fiber-on-the-gut-microbiome-in-healthy-adults-100583198",false,"NCT06873204","Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults","RDA Cereal Fiber Clinical","Inclusion Criteria:\n\n* Men or women.\n* Aged between 18-45 years.\n* Body mass index between 18.5 and 25 kg\u002Fm².\n* Able to read\u002Fspeak English.\n\nExclusion Criteria:\n\n* Gastrointestinal disorders (inflammatory bowel disease, irritable bowel syndrome, gluten sensitivity\u002Fintolerance, etc.).\n* Those who took antibiotics 3 months before the study.\n* Individuals taking regular medication or supplements that might affect the gut microbiota.\n* Individuals undertaking weight-loss diets.\n* Unstable body weight (±3 kg in the past 3 months), and individuals below 110 lb.\n* Heavy drinkers (for men, consuming more than 4 drinks on any day or more than 14 drinks per week; for women, consuming more than 3 drinks on any day or more than 7 drinks per week).\n* Smokers (those who have smoked 100 cigarettes in their lifetime and who currently smoke cigarettes, even every day or occasionally).\n* Breastfeeding or pregnant women.",true,"ALL","18 Years","45 Years",{"count":87,"type":88},25,"ESTIMATED","INTERVENTIONAL",[91],"NA","The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota. The soluble fiber in cereal by-products, arabinoxylan (AX), is known to be beneficial for generally promoting gut health. However, it is unclear whether consuming rice bran (RB), the source of AX, is equally helpful or better than consuming the extracted form of AX. This study aims to reveal the potential benefit of insoluble cereal bran fiber ingredients by comparing the effect of soluble arabinoxylan fiber alone and the mostly insoluble rice bran fiber, containing arabinoxylan, on intestinal health and gut microbiota. A placebo (maltodextrin) will be used as a control, with no significant changes expected in this group for the evaluated outcomes.\n\nParticipants will:\n\n* Consume two different fiber supplements (soluble arabinoxylan or stabilized rice bran) as well as a placebo (maltodextrin) for 3 weeks each, separated by a 2-week washout period.\n* Provide blood and stool samples at six different time points.\n* Complete a food and gastrointestinal symptom diary during the intervention periods.",[94],"Healthy",[96,97,98,99,100,101,102,103],"Gut microbiota","Dietary fiber","Soluble arabinoxylan","Rice bran fiber","Intestinal health","Butyrate-producing bacteria","Clostridium cluster IVa","Short-Chain Fatty Acids","NOT_YET_RECRUITING","2025-06-25",{"date":107,"type":108},"2025-06-29","ACTUAL",{"date":110,"type":88},"2025-07",{"date":112,"type":88},"2025-10",{"name":5,"class":6},1]