[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600279":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":47,"collaborators":20,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":20,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":20,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Ball State University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Inulin Supplement","EXPERIMENTAL","Participants will consume 6g of pre-portioned powdered inulin from chicory root daily for one week followed by 12g daily for eight weeks. Participants will fully dissolve it into a habitual cool or room temperature beverage to drink around the same time each day.",[13],"Dietary Supplement: inulin",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIETARY_SUPPLEMENT","inulin","6g inulin from chicory root per day for one week and 12g inulin per day for eight weeks dissolved into cool or room temperature liquid",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Bryant Keirns, PhD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","765-285-8356","bryant.keirns@bsu.edu",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Health Professions Building","RECRUITING","Muncie","Indiana","47306","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-85.38636,40.19338,{"lat":43,"lon":42},[46],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},{"type":24,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Bryant Keirns","Assistant Professor","100600279","impact-of-supplemental-fiber-on-gut-and-vascular-health-related-in-obesity-phenotypes-100600279",false,"NCT07095426","Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes","Interplay Between Metabolic Risk Factors, Body Mass Index, and the Gut\u002FVascular Response to Supplemental Fiber","Inclusion Criteria:\n\n* Participants are 18-55 years old.\n* Participants BMI is ≥30 kg\u002Fm2 - this BMI requirement is due to our research aims.\n* Participants have either 0-1 or 2+ of the following risk factors outside of the normal reference ranges: blood pressure, blood sugar, triglycerides, and HDL-cholesterol.\n* Participants are not pregnant or expecting to become pregnant (females only). •Participants are not postmenopausal (females only).\n* Participants have not been diagnosed with an advanced cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes).\n* Participants have not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease, diverticulosis\u002Fdiverticulitis).\n* Participants do not regularly take anti-inflammatory drugs (more than 2x week) and are willing to suspend use of these medications for 3 days leading up to in-lab visits.\n* Participants do not take weight-loss medications (e.g., Ozempic, Wegovy).\n* Participants do not use tobacco products or any illicit drugs.\n* Participants have not used antibiotics or probiotics in the last month.\n* Participants do not have dietary restrictions prohibiting them from consuming the fiber supplement (e.g., food allergies\u002Fintolerance).\n* Participants do not have a pacemaker.\n* Participants are able to lie on their back (supine position) in the dark for at least 10 minutes (related to vascular measurements).\n\nExclusion Criteria:\n\n* Participants are not 18-55 years old.\n* Participants BMI is not ≥30 kg\u002Fm2 - this BMI requirement is due to our research aims.\n* Participants do not have either 0-1 or 2+ of the following risk factors outside of the normal reference ranges: blood pressure, blood sugar, triglycerides, and HDL-cholesterol.\n* Participants are pregnant or expecting to become pregnant (females only).\n* Participants are postmenopausal (females only).\n* Participants have been diagnosed with an advanced cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes).\n* Participants have been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease, diverticulosis\u002Fdiverticulitis). •Participants regularly take anti-inflammatory drugs (more than 2x week) and are not willing to suspend use of these medications for 3 days leading up to in-lab visits.\n* Participants take weight-loss medications (e.g., Ozempic, Wegovy).\n* Participants use tobacco products or any illicit drugs.\n* Participants have used antibiotics or probiotics in the last month.\n* Participants have dietary restrictions prohibiting them from consuming the fiber supplement (e.g., food allergies\u002Fintolerance).\n* Participants have a pacemaker.",true,"ALL","18 Years","55 Years",{"count":62,"type":63},20,"ESTIMATED","INTERVENTIONAL",[66],"NA","Based on prior research, the investigators are interested in whether an intervention targeting gut health (supplemental fiber for 9 weeks total) will improve vascular health in individuals with obesity. Additionally, the investigators are interested in if this response differs based on whether individuals with obesity have very few heart disease risk factors or several heart disease risk factors.",[69,70,71,72],"Metabolic Syndrome","Healthy Participants","Metabolically Healthy Obesity","Metabolically Abnormal Obesity",[74,75,76,77],"fiber","vascular health","gut health","inflammation","2025-07-24",{"date":80,"type":81},"2025-07-31","ACTUAL",{"date":83,"type":81},"2025-05-20",{"date":85,"type":63},"2027-05",{"name":5,"class":6},1]