[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100506928":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":45,"centralContacts":49,"locations":59,"responsibleParty":79,"collaborators":82,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":94,"acronym":53,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":97,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":53,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":62,"whyStopped":53,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Columbia University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Stable Adequate Sleep (SAS)","ACTIVE_COMPARATOR","Participants will go to bed and wake up at the same time every night, maintaining adequate sleep duration.",[13],"Behavioral: Sustained Adequate Sleep (SAS)",{"label":15,"type":16,"description":17,"interventionNames":18},"ISS_Alone","EXPERIMENTAL","Intermittent short sleep (ISS) 5 nights of 5.5 hours time in bed 2 nights of 9.5 hours time in bed with advanced bedtimes and delayed wake times",[19],"Behavioral: Intermittent Short Sleep (ISS)",{"label":21,"type":16,"description":22,"interventionNames":23},"ISS_SJL","Intermittent short sleep with short jetlag (SJL) 5 nights of 5.5 hours time in bed 2 nights of 9.5 hours time in bed with constant bedtimes and delayed wake times",[19,24],"Behavioral: Social Jetlag (SJL)",[26,33,39],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"BEHAVIORAL","Intermittent Short Sleep (ISS)","Restricted sleep duration of \\\u003C5.5 h\u002Fnight for 5 nights (SR) followed by 2 nights of 9.5 hours of time in bed (TIB) (recover sleep) each week.",[15,21],[32],"ISS",{"type":27,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Social Jetlag (SJL)","2-hour delayed sleep timing.",[21],[38],"SJL",{"type":27,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"Sustained Adequate Sleep (SAS)","Goal of ≥7 hours of sleep\u002Fnight with 8 hours of time in bed (TIB).",[9],[44],"SAS",[46],{"name":47,"affiliation":5,"role":48},"Marie-Pierre St-Onge, PhD","PRINCIPAL_INVESTIGATOR",[50,55],{"name":47,"role":51,"phone":52,"phoneExt":53,"email":54},"CONTACT","212-305-9549",null,"ms2554@cumc.columbia.edu",{"name":56,"role":51,"phone":57,"phoneExt":53,"email":58},"Greiby Mercedes","646-761-3455","gdm2130@cumc.columbia.edu",[60],{"facility":61,"status":62,"city":63,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"Columbia University Irving Medical Center","RECRUITING","New York","10032","United States","US",{"type":68,"coordinates":69},"Point",[70,71],-74.00597,40.71427,{"lat":71,"lon":70},[74,75,76],{"name":47,"role":51,"phone":52,"phoneExt":53,"email":54},{"name":47,"role":48,"phone":53,"phoneExt":53,"email":53},{"name":77,"role":78,"phone":53,"phoneExt":53,"email":53},"Sanja Jelic, MD","SUB_INVESTIGATOR",{"type":48,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":53,"oldOrganization":53},"Marie-Pierre St-Onge","Associate Professor",[83,85,87],{"name":84,"class":6},"Icahn School of Medicine at Mount Sinai",{"name":86,"class":6},"University of Colorado, Denver",{"name":88,"class":89},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100506928","impact-of-yo-yo-sleep-on-cardiometabolic-health-100506928",false,"NCT05880758","Impact of Yo-Yo Sleep on Cardiometabolic Health","Inclusion Criteria:\n\n* Aged 18 to 49 years\n* BMI 20-29.9 kg\u002Fm2\n* Habitually sleeping 7-9 hours\u002Fnight without sleep aids or naps\n\nExclusion Criteria:\n\n* Sleep disorders\n* Psychiatric disorders (including eating disorders) and seasonal affective disorder\n* Pregnancy (current\u002Fprior year)\n* Breastfeeding\n* Smokers (Any cigarette smoking or ex-smokers \\\u003C3years)\n* Diabetes\n* Elevated blood pressure, taking beta-blockers\n* Individuals taking anti-coagulants or anti-platelets\n* Recent weight change or participation in a weight loss program or have ever had bariatric surgery or other weight loss or gastrointestinal procedure.\n* Travel across time zones; shift work (non-traditional hours)",true,"ALL","18 Years","49 Years",{"count":101,"type":102},72,"ESTIMATED","INTERVENTIONAL",[105],"NA","The goal of this clinical trial is to test the impact of repeated intermittent short sleep, with short sleep maintained 5 days per week followed by 2 days of prolonged sleep, compared to daily adequate sleep, on energy balance and cardiometabolic risk. A secondary goal of this research is to determine if maintaining a constant midpoint of sleep while undergoing intermittent short sleep, leads to better outcomes than intermittent short sleep with a 2-hour delay in sleep midpoint. The aims of this research will be tested in the context of a 3-group, parallel-arm, outpatient intervention of 4 weeks in duration, in young-to-middle-aged adults (aged 18-49 years).",[108,109],"Cardiometabolic Syndrome","Obesity",[111,112,113],"Sleep","Circadian Rhythms","Cardiometabolic Health","2026-05-14",{"date":116,"type":117},"2026-05-18","ACTUAL",{"date":119,"type":117},"2023-09-22",{"date":121,"type":102},"2028-06",{"name":5,"class":6},1]