[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642411":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":29,"responsibleParty":46,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":10,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients on ART planning for regimen switch",null,"virally suppressed with viral undetectable at 2 consecutive timepoints prior to enrolment",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients on ART not for regimen switch","with and without low level viraemia prior to enrolment",[16],{"name":17,"affiliation":18,"role":19},"Shui Shan Lee, MD","S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong kong","PRINCIPAL_INVESTIGATOR",[21,25],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","+852 22528812","sslee@cuhk.edu.hk",{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},"Ngai Sze Wong, PhD","+852 22528862","candy_wong@cuhk.edu.hk",[30],{"facility":31,"status":32,"city":33,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong","RECRUITING","Hong Kong","0000","China","CN",{"type":38,"coordinates":39},"Point",[40,41],114.17469,22.27832,{"lat":41,"lon":40},[44,45],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},{"type":19,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Shui-Shan Lee, MD","Research Professor","100642411","impacts-of-hiv-treatment-regimens-on-archived-drug-resistance-100642411",false,"NCT07643948","Impacts of HIV Treatment Regimens on Archived Drug Resistance","Impact of Antiretroviral Therapy (ART) Switch on Archived HIV-1 Drug Resistance in Virally Suppressed Patients: A Prospective Cohort Study","Inclusion Criteria:\n\n* Patients living with HIV who are (a) aged 18 or above, (b) on antiretroviral therapy, (c) has viral load \\\u003C20 copies\u002FmL at 2 time points for ≥6 months, (d) planning regimen switch.\n* Patients for inclusion in the control group meet the same criteria (a) but they are not planned for switch. Controls include patients with low level viremia (LLV) as defined as ≥2 consecutive viral load level between 21 and 200 copies\u002FmL in the preceding 2 years.\n\nExclusion Criteria:\n\n* Patients living with HIV who (a) are pregnant, (b) have virologic failure, (c) are suffering from concurrent opportunistic infections, (d) are prisoners , (e) are unable to give consent, and (f) have mental illnesses.","ALL","18 Years",{"count":59,"type":60},420,"ESTIMATED","OBSERVATIONAL","The study aims to determine the prevalence of drug resistance mutation (DRM) in virally suppressed HIV infection, and the impacts of regimen change and the presence of low level viremia. Adults living with HIV infection on antiretroviral therapy (ART) with full viral suppression would be recruited. Cases are patients planning for regimen switch, while controls are those with and without low level viraemia (LLV) not planned for switch. Blood samples would be collected before and after switch. Sequencing would be performed to identify DRM present in HIV-1 proviral DNA.",[64,65,66],"HIV -1 Infection","Antiretroviral Therapy","Drug Resistance, Microbial",[68,69,70,71,72,73],"antiretroviral therapy","regimen switch","archived resistance","low level viremia","proviral DNA","HIV infection","2026-06-10",{"date":76,"type":77},"2026-06-12","ACTUAL",{"date":79,"type":77},"2025-10-01",{"date":81,"type":60},"2029-12-31",{"name":5,"class":6},1]