[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570969":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":38,"responsibleParty":58,"collaborators":62,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":24,"enrollmentInfo":82,"targetDuration":24,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Universitaire Ziekenhuizen KU Leuven","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Allergic subjects","All subject with positive skin prick testing for grass and\u002For birch pollen are assigned to this group.",[12],"Diagnostic Test: Immunoreactivity testing",{"label":14,"type":6,"description":15,"interventionNames":16},"Healthy controls","Subjects with negative skin prick testing for grass and\u002For birch pollen are assigned to this group and used for as negative controls in our experiments.",[17],"Diagnostic Test: Immunoreactivity testing (negative control)",[19,25],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","Immunoreactivity testing","Blood samples will be collected and used to determine the intensity of the allergenicity of the subject toward different types of pollen. This will be done by the detection of sIgE antibodies to the pollen extracts and basophil activation testing (BAT) with pollen extracts.",[9],null,{"type":20,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Immunoreactivity testing (negative control)","Blood samples will be collected and used to determine the background activity of our immunoreactivity tests. The investigators will use samples from negative controls to demonstrate that non-allergic individuals do not react to our assays, confirming that our pollen extracts have no background reactivity. This will be done by the detection of sIgE antibodies to the pollen extracts and basophil activation testing (BAT) with pollen extracts.",[14],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Rik Schrijvers, MD, PhD","CONTACT","+3216342985","rik.schrijvers@uzleuven.be",{"name":36,"role":32,"phone":24,"phoneExt":24,"email":37},"Raf Aerts, PhD","raf.aerts@sciensano.be",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"University Hospitals Leuven","RECRUITING","Leuven","Vlaams-Brabant","3000","Belgium","BE",{"type":48,"coordinates":49},"Point",[50,51],4.70093,50.87959,{"lat":51,"lon":50},[54],{"name":55,"role":32,"phone":56,"phoneExt":24,"email":57},"Paulien Verscheure, MSc","+3216338861","paulien.verscheure@kuleuven.be",{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"SPONSOR_INVESTIGATOR","prof. dr. Rik Schrijvers","Prof. dr.",[63,66,68,70],{"name":64,"class":65},"Sciensano","OTHER_GOV",{"name":67,"class":6},"KU Leuven",{"name":69,"class":6},"University of Namur",{"name":71,"class":6},"Université Catholique de Louvain","100570969","impacts-of-nitrogen-deposition-in-the-natural-environment-on-pollen-allergy-in-belgium-100570969",false,"NCT06714149","Impacts of Nitrogen Deposition in the Natural Environment on Pollen Allergy in Belgium","NITROPOL-BE","Inclusion Criteria:\n\n* Positive skin prick test for grass and\u002For birch pollen\n\nExclusion Criteria:\n\n* Desensitization therapy during the last two years",true,"ALL","18 Years",{"count":83,"type":84},200,"ESTIMATED","INTERVENTIONAL",[87],"NA","The investigators want to study the effect of environmental nitrogen enrichment on the allergy burden in pollen-sensitized subjects.",[90],"Pollen Allergy",[92,93,94],"Nitrogen","Pollution","Pollen allergy","2024-12-02",{"date":97,"type":98},"2024-12-03","ACTUAL",{"date":100,"type":98},"2022-06-29",{"date":102,"type":84},"2025-04",{"name":60,"class":6},1]