[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100490198":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":37,"locations":46,"responsibleParty":64,"collaborators":67,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":87,"minAge":88,"maxAge":10,"enrollmentInfo":89,"targetDuration":10,"studyType":92,"phases":10,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"University of Dublin, Trinity College","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Controls",null,"Individuals from the Irish population with no psychiatric, psychological, neurological or muscular disease diagnosis.",[13],"Procedure: 128 electrode electroencephalography (EEG), Bipolar surface electromyography (sEMG), High-density electromyography (HD-EMG)",{"label":15,"type":10,"description":16,"interventionNames":17},"Amyotrophic lateral sclerosis patients","Individuals from the Irish population (Irish Motorneuron Disease Register) with possible\u002Fprobable\u002Fdefinitive diagnosis of ALS.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Postpoliomyelitis syndrome","Individuals from the Irish population (Irish Motorneuron Disease Register) with postpoliomyelitis syndrome diagnosis.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Spinal Muscular Atrophy","Individuals from the Irish population (Irish Motorneuron Disease Register) with spinal muscular atrophy diagnosis.",[13],[27],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":10},"PROCEDURE","128 electrode electroencephalography (EEG), Bipolar surface electromyography (sEMG), High-density electromyography (HD-EMG)","128 electrode EEG and 8 bipolar EMG or HD-EMG will be noninvasively recorded from electrodes placed in a montage over the scalp and arm muscles while the participant is resting or performing tasks designed to engage specific cortical networks of interest (cognitive, behavioural, motor and sensory)",[15,9,19,23],[33],{"name":34,"affiliation":35,"role":36},"Orla Hardiman, BSc MB BCh BAO MD FRCPI FAAN","Academic Unit of Neurology, Trinity College Dublin, The University of Dublin","PRINCIPAL_INVESTIGATOR",[38,42],{"name":34,"role":39,"phone":40,"phoneExt":10,"email":41},"CONTACT","+353 1 896 4497","hardimao@tcd.ie",{"name":43,"role":39,"phone":44,"phoneExt":10,"email":45},"Saroj Bista, MSc","+353 89 945 8246","sbista@tcd.ie",[47],{"facility":35,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Dublin","Leinster","Dublin 2","Ireland","IE",{"type":55,"coordinates":56},"Point",[57,58],-6.24889,53.33306,{"lat":58,"lon":57},[61,63],{"name":62,"role":39,"phone":40,"phoneExt":10,"email":41},"Orla Hardiman,, BSc MB BCh BAO MD FRCPI FAAN",{"name":43,"role":39,"phone":44,"phoneExt":10,"email":45},{"type":36,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Orla Hardiman","Professor of Neurology",[68,71,73,75,77],{"name":69,"class":70},"Motor Neurone Disease Association, UK","UNKNOWN",{"name":72,"class":70},"Irish Research Council, IE",{"name":74,"class":70},"Research Motor Neuron, IE",{"name":76,"class":70},"Thierry Latran Foundation, FR",{"name":78,"class":70},"ALS Association, USA","100490198","impairments-of-neuro-muscular-communication-in-motor-neuron-disease-a-bio-marker-for-early-and-personalised-diagnosis-100490198",false,"NCT05663008","Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised Diagnosis","MotorMarker","Inclusion Criteria:\n\nHealthy Volunteers:\n\n* age and gender-matched to patient groups\n* the intact physical ability to take part in the experiment.\n\nPatients:\n\n* Diagnosis of ALS, PLS, PMA, SMA, Polio or MS\n* capable of providing informed consent.\n\nExclusion Criteria:\n\nHealthy Controls:\n\n* History of neuromuscular\n* neurological or active psychiatric disease disease\n* history of reaction or allergy to recording environments, equipment and the recording gels.\n\nPatients:\n\n* the presence of active psychiatric disease\n* any medical condition associated with severe neuropathy (e.g. poorly controlled diabetes).\n* History of reaction or allergy to recording environments, equipment and the recording gels.",true,"ALL","18 Years",{"count":90,"type":91},400,"ESTIMATED","OBSERVATIONAL","Motor neuron disease (MND) or ALS is a nervous system disease. ALS leads to a loss of movement ability that eventually leads to death. At the moment, there is no known treatment for ALS. Early diagnosis in individuals improves clinical care and facilitates timely entry into clinical trials. However, current methods for diagnosis are primarily clinical, and to date, no cost-effective biomarkers have been developed. Our objective is to identify a robust non-invasive neurophysiological-based system that can be used both as a biomarker of disease onset, and a measurement of progression using quantitative EEG and surface EMG (bipolar and high-density).\n\nThe investigators postulate that analysing the joint recordings of EEG and EMG (bipolar or high-density) can give measures that better distinguish healthy people and ALS patient subgroups and that the findings can be developed as biomarkers of early diagnosis and disease progression.",[95,96,23],"ALS (Amyotrophic Lateral Sclerosis)","Postpoliomyelitis Syndrome",[98,99,100,101,102,103],"EEG","Corticomuscular coherence","Biomarkers","Electrophysiology","Neuromuscular disease","EMG","2022-12-21",{"date":106,"type":107},"2022-12-23","ACTUAL",{"date":109,"type":107},"2015-10-01",{"date":111,"type":91},"2027-09-30",{"name":5,"class":6},1]