[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100464371":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":43,"responsibleParty":76,"collaborators":78,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":89,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":10,"studyType":100,"phases":10,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"ICM group",null,"Patients eligible for ICM implantation for screening of atrial fibrillation",[13,14],"Device: CONFIRM Rx implantable cardiac rhythm monitor (Abbott)","Diagnostic Test: Systematic etiologic work-up for underlying causes of MINOCA",{"label":16,"type":10,"description":17,"interventionNames":18},"Non-ICM group","Patients ineligible for ICM implantation due to 1) refusal, 2) contraindication, or 3) clear underlying cause of MINOCA before ICM implantation.",[14],[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"DEVICE","CONFIRM Rx implantable cardiac rhythm monitor (Abbott)","Implantation of CONFIRM Rx ICM",[9],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"DIAGNOSTIC_TEST","Systematic etiologic work-up for underlying causes of MINOCA","Intracoronary optical coherence tomography, cardiac magnetic resonance imaging, transesophageal echocardiography, vasospasm testing, thrombophilia screening, Holter ECG (only non-ICM group)",[9,16],[31],{"name":32,"affiliation":33,"role":34},"Lorenz Räber, MD, PhD","Bern University Hospital Inselspital","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":10,"email":39},"CONTACT","+41 31 632 50 00","lorenz.raeber@insel.ch",{"name":41,"role":37,"phone":10,"phoneExt":10,"email":42},"Sarah Bär, MD","sarah.baer@insel.ch",[44,61],{"facility":33,"status":45,"city":46,"state":10,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Bern","3010","Switzerland","CH",{"type":51,"coordinates":52},"Point",[53,54],7.44744,46.94809,{"lat":54,"lon":53},[57,59],{"name":32,"role":37,"phone":58,"phoneExt":10,"email":39},"+41 31 632 09 29",{"name":41,"role":37,"phone":60,"phoneExt":10,"email":42},"+41 31 632 21 11",{"facility":62,"status":45,"city":63,"state":10,"zip":64,"country":48,"countryCode":49,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"University Hospital Zurich USZ","Zurich","8091",{"type":51,"coordinates":66},[67,68],8.55,47.36667,{"lat":68,"lon":67},[71,75],{"name":72,"role":37,"phone":73,"phoneExt":10,"email":74},"Barbara Stähli, MD","+41 43 253 05 97","barbara.staehli@usz.ch",{"name":72,"role":34,"phone":10,"phoneExt":10,"email":10},{"type":77,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[79,81,84],{"name":80,"class":6},"University Hospital, Zürich",{"name":82,"class":83},"Bangerter-Rhyner Stiftung","UNKNOWN",{"name":85,"class":86},"Abbott","INDUSTRY","100464371","implantable-cardiac-monitor-to-detect-atrial-fibrillation-in-patients-with-minoca-100464371",false,"NCT05326828","Implantable Cardiac Monitor to Detect Atrial Fibrillation in Patients With MINOCA","MINOCA","Inclusion Criteria ICM group\n\n1. ≥18 years of age\n2. Written informed consent\n3. Acute myocardial infarction (AMI) type 1 in accordance with the 4th universal definition of myocardial infarction\n4. Non-obstructive coronary arteries on angiography defined as the absence of coronary artery stenoses ≥50% in any potential infarct-related artery\n5. No clinically overt specific cause for the acute presentation\n6. Subendocardial or transmural late gadolinum enhancement (LGE) consistent with an ischemic etiology on cardiac magnetic resonance imaging (CMR)\n7. No clear underlying cause of MINOCA and therefore increased probability of atrial fibrillation\n\nExclusion Criteria ICM group:\n\n1. Known atrial fibrillation or atrial flutter\n2. History of atrial fibrillation or atrial flutter ablation\n3. Known coronary artery disease\n4. Previous MI\n5. Previous percutaneous coronary intervention (PCI)\n6. Previous coronary artery bypass grafting (CABG)\n7. Contraindications to CMR (i.e. non-MR-compatible implantable cardiac device, glomerular filtration rate (GFR) \\\u003C30 ml\u002Fmin)\n8. Contraindications to ICM implantation\n9. Clear underlying cause of MINOCA before ICM implantation\n\nInclusion Criteria non-ICM group:\n\n1. ≥18 years of age\n2. Written informed consent\n3. AMI type 1 in accordance with the 4th universal definition of myocardial infarction\n4. Non-obstructive coronary arteries on angiography defined as the absence of coronary artery stenoses ≥50% in any potential infarct-related artery\n5. No clinically overt specific cause for the acute presentation\n6. Subendocardial or transmural LGE consistent with an ischemic etiology on CMR\n\nExclusion Criteria non-ICM group:\n\n1. Known coronary artery disease\n2. Previous MI\n3. Previous PCI\n4. Previous CABG\n5. Contraindications to CMR (i.e. non-MR-compatible implantable cardiac device, GFR \\\u003C30 ml\u002Fmin)","ALL","18 Years","85 Years",{"count":98,"type":99},60,"ESTIMATED","OBSERVATIONAL","Myocardial infarction with non-obstructive coronary arteries (MINOCA) (i.e.\\\u003C50% stenoses) on coronary angiography) is an underappreciated clinical entity concerning 5-6% of patients with acute myocardial infarction. Approximately 50% of these patients remain without appropriate diagnosis and treatment.\n\nThe MINOCA study aims at systematically assessing the frequency of underlying pathologies of MINOCA and outcomes with a multidisciplinary etiologic work-up and follow-up of 5 years including, for the first time, an implantable cardiac monitor (ICM) to assess the frequency of atrial fibrillation as underlying cause for MINOCA.",[92,103],"Atrial Fibrillation",[105],"Implantable cardiac monitor","2024-10-28",{"date":108,"type":109},"2024-10-30","ACTUAL",{"date":111,"type":109},"2022-05-24",{"date":113,"type":99},"2031-05-15",{"name":5,"class":6},2]