[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628314":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":25,"responsibleParty":30,"collaborators":25,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":38,"acronym":25,"eligibilityCriteria":39,"healthyVolunteers":36,"sex":40,"minAge":41,"maxAge":25,"enrollmentInfo":42,"targetDuration":25,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":25,"overallStatus":54,"whyStopped":25,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":25},{"fullName":5,"class":6},"Al-Azhar University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pre-protocol Group (Baseline)","PLACEBO_COMPARATOR","his retrospective cohort includes 74 adult patients with suspected sepsis or septic shock treated at AFHJ between January and December 2024. This arm represents the \"standard of care\" prior to the formal implementation of the adapted sepsis management protocol.",[13],"Other: Standard Clinical Care",{"label":15,"type":16,"description":17,"interventionNames":18},"Protocol Group (Intervention)","EXPERIMENTAL","his prospective cohort includes 46 adult patients with suspected sepsis or septic shock treated at AFHJ between January and July 2025. These patients were managed according to a structured sepsis protocol involving early screening (NEWS2\u002FSOFA) and the \"one-hour bundle.\"",[19],"Other: Adapted Surviving Sepsis Campaign (SSC) Protocol",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Adapted Surviving Sepsis Campaign (SSC) Protocol","A multi-component clinical management strategy focusing on early recognition and rapid treatment. Key elements include:\n\nScreening: Use of National Early Warning Score 2 (NEWS2) at triage.\n\nDiagnosis: Use of Sequential Organ Failure Assessment (SOFA) to identify organ dysfunction.\n\nThe One-Hour Bundle: Execution of five tasks within 60 minutes: (1) Measuring lactate, (2) Obtaining blood cultures, (3) Administering broad-spectrum antibiotics, (4) IV fluid resuscitation (30 mL\u002Fkg) for hypotension or high lactate, and (5) Vasopressors to maintain MAP ≥ 65 mmHg.",[15],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Standard Clinical Care","Traditional sepsis management as practiced at the institution prior to the implementation of the standardized QI protocol. This care was characterized by inconsistent bundle compliance and variable timing of antibiotic administration and fluid resuscitation.",[9],{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Tarik Saber Sarhan","Associate Professor Doctor","100628314","implementation-of-timely-management-of-sepsis-and-septic-shock-protocol-in-the-emergency-department-and-intensive-care-unit-a-quality-improvement-project-at-afhj-100628314",false,"NCT07460024","Implementation of Timely Management of Sepsis and Septic Shock Protocol in the Emergency Department and Intensive Care Unit: A Quality Improvement Project at AFHJ","Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* Clinical suspicion of sepsis or a confirmed diagnosis of sepsis upon admission to the Emergency Department (ED) or Intensive Care Unit (ICU).\n* Presence of symptoms meeting the criteria for the sepsis management protocol during the study period.\n\nExclusion Criteria:\n\n* Patients transferred from other healthcare facilities after sepsis treatment had already been initiated.\n* End-of-life cases or patients with \"Do Not Attempt Resuscitation\" (DNAR) status where data sets are incomplete.\n* Cases with insufficient medical documentation that prevents accurate outcome measurement or bundle compliance tracking.","ALL","18 Years",{"count":43,"type":44},120,"ESTIMATED","INTERVENTIONAL",[47],"NA","Study Title: Implementation of a Sepsis Management Protocol at Armed Forces Hospital Jazan (AFHJ).\n\nPurpose: The purpose of this quality improvement project is to determine if implementing a standardized, evidence-based \"sepsis bundle\" can improve the care and survival of patients with sepsis and septic shock in the Emergency Department (ED) and Intensive Care Unit (ICU).\n\nWhat the Study Involves:\n\nResearchers will implement a specific set of clinical guidelines based on the international Surviving Sepsis Campaign. This include:\n\nUsing a scoring system (NEWS2 and SOFA) to identify sick patients earlier.\n\nEnsuring patients receive five critical treatments (the \"one-hour bundle\") within 60 minutes of diagnosis, including blood tests, IV fluids, and antibiotics.\n\nComparison:\n\nThe study will compare the outcomes of 74 patients treated before the protocol was introduced (the \"Pre-protocol group\") to 46 patients treated after the new protocol was put into effect (the \"Protocol group\").\n\nExpected Outcome:\n\nThe goal is to increase the number of patients who receive all necessary treatments within one hour from less than 15% to at least 60%. The study also aims to see if this protocol leads to shorter hospital stays and lower mortality rates.",[50,51,52,53],"Sepsis","Septic Shock","Systemic Inflammatory Response Syndrome (SIRS)","Critical Illness","NOT_YET_RECRUITING","2026-03-09",{"date":57,"type":58},"2026-03-10","ACTUAL",{"date":60,"type":44},"2026-03",{"date":62,"type":44},"2026-11",{"name":5,"class":6}]