[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100524165":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":21,"responsibleParty":87,"collaborators":90,"id":105,"slug":106,"hasResults":107,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":107,"sex":113,"minAge":114,"maxAge":7,"enrollmentInfo":115,"targetDuration":118,"studyType":119,"phases":7,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":52,"whyStopped":7,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":139},{"fullName":5,"class":6},"Catharina Ziekenhuis Eindhoven","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Volkher Scharnhorst, Prof.Dr.","PRINCIPAL_INVESTIGATOR",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Hao Cao, MSc","CONTACT","+31402398644","hao.cao@catharinaziekenhuis.nl",{"name":10,"role":15,"phone":19,"phoneExt":7,"email":20},"+31402398640","volkher.scharnhorst@catharinaziekenhuis.nl",[22,39,51,63,75],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"Zuyderland Medical Center","NOT_YET_RECRUITING","Heerlen","Limburg","6419PC","Netherlands","NL",{"type":31,"coordinates":32},"Point",[33,34],5.98154,50.88365,{"lat":34,"lon":33},[37],{"name":38,"role":15,"phone":7,"phoneExt":7,"email":7},"Michiel Gronenschild, MD",{"facility":40,"status":24,"city":41,"state":26,"zip":42,"country":28,"countryCode":29,"cosmosGeoPoint":43,"geoPoint":47,"contacts":48},"Maastricht University Medical Center","Maastricht","6229HX",{"type":31,"coordinates":44},[45,46],5.68889,50.84833,{"lat":46,"lon":45},[49],{"name":50,"role":15,"phone":7,"phoneExt":7,"email":7},"Lizza Hendriks, MD, PhD",{"facility":5,"status":52,"city":53,"state":54,"zip":55,"country":28,"countryCode":29,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"RECRUITING","Eindhoven","North Brabant","5623EJ",{"type":31,"coordinates":57},[58,59],5.47778,51.44083,{"lat":59,"lon":58},[62],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},{"facility":64,"status":24,"city":65,"state":54,"zip":66,"country":28,"countryCode":29,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"St. Anna Ziekenhuis","Geldrop","5664EH",{"type":31,"coordinates":68},[69,70],5.55972,51.42167,{"lat":70,"lon":69},[73],{"name":74,"role":15,"phone":7,"phoneExt":7,"email":7},"Gerben Stege, MD, PhD",{"facility":76,"status":24,"city":77,"state":54,"zip":78,"country":28,"countryCode":29,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Máxima Medisch Centrum","Veldhoven","5504DB",{"type":31,"coordinates":80},[81,82],5.40278,51.41833,{"lat":82,"lon":81},[85],{"name":86,"role":15,"phone":7,"phoneExt":7,"email":7},"Magdolen El Soud-Youssef, MD",{"type":11,"investigatorFullName":88,"investigatorTitle":89,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Volkher Scharnhorst","Prof. Dr. (Clinical Chemist)",[91,93,96,98,100,101,103],{"name":92,"class":6},"Eindhoven University of Technology",{"name":94,"class":95},"Roche BV Netherlands","UNKNOWN",{"name":97,"class":6},"Maxima Medical Center",{"name":99,"class":6},"Zuyderland Medisch Centrum",{"name":40,"class":6},{"name":102,"class":6},"St. Anna Ziekenhuis, Geldrop, Netherlands",{"name":104,"class":6},"The Netherlands Cancer Institute","100524165","implementation-of-up-front-ctdna-into-lung-cancer-care-and-development-of-liquid-biopsy-based-decision-support-models---lm-study-100524165",false,"NCT06105177","Implementation of Up-front ctDNA Into Lung Cancer Care and Development of Liquid Biopsy-based Decision Support Models - LM² Study","Implementation of Up-front ctDNA Analysis Into Lung Cancer Care and Development of Liquid Biopsy-based Decision Support Models - the Lungmarker² Study","LM2","Inclusion Criteria:\n\n* Aged 18 or above and suspected of having lung cancer\n\nExclusion Criteria:\n\n* Presence of another malignant tumor, i.e. diagnosed with a tumor in the past 5 years","ALL","18 Years",{"count":116,"type":117},800,"ESTIMATED","36 Months","OBSERVATIONAL","Despite scientific evidence, use of liquid biopsy (LB) in diagnosis and monitoring of lung cancer (LC) is limited since it requires major changes in diagnostic and care pathways. Analyzing tumor markers (TMs), circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in blood (LB) can inform about the nature of the tumor, the most appropriate therapy, therapy response and resistance.\n\nLungmarker2 is a multicenter, prospective, implementation and diagnostic cohort study. This study aims to implement up-front ctDNA analysis ('plasma first approach') into routine diagnostic work-up of all advanced stage LC patients in the Southeast of the Netherlands (the participating hospitals in the OncoZON region). Thereby, additional information about the molecular make-up of the tumor becomes available, the number of tissue Next-Generation Sequencing (NGS) analyses will decrease and time to therapeutic decision making is shortened. Next, using ctDNA, TM and other information, multi-parametric decision support models are built and validated that may support diagnosis, predict the outcome of the next imaging procedure and progression-free survival during follow-up. The final goal is to develop a super-resolution microscopy test that can detect PD-L1 expression on CTCs.",[122],"Lung Cancer",[124,125,126,127,128,129],"lungmarker2 study","lung cancer","liquid biopsy","ctDNA","CTCs","tumormarkers","2024-09-10",{"date":132,"type":133},"2024-09-19","ACTUAL",{"date":135,"type":133},"2023-10-31",{"date":137,"type":117},"2026-10",{"name":5,"class":6},5]