[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629369":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":51,"centralContacts":55,"locations":61,"responsibleParty":329,"collaborators":10,"id":331,"slug":332,"hasResults":333,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":337,"eligibilityCriteria":338,"healthyVolunteers":333,"sex":339,"minAge":340,"maxAge":10,"enrollmentInfo":341,"targetDuration":10,"studyType":344,"phases":10,"briefSummary":345,"conditions":346,"keywords":10,"overallStatus":64,"whyStopped":10,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":357},{"fullName":5,"class":6},"Gilead Sciences","INDUSTRY",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"LEN PrEP",null,"Participants in diverse clinical settings in the United States (US) who choose subcutaneous (SC) Lenacapavir (LEN) Pre-Exposure Prophylaxis for HIV Prevention (PrEP) at enrollment in the study or anytime during the follow-up period",[13,14],"Drug: Lenacapavir Injection","Drug: Lenacapavir Tablet",{"label":16,"type":10,"description":17,"interventionNames":18},"Other PrEP","Participants in diverse clinical settings in the United States (US) who choose other PrEP options ( F\u002FTDF, F\u002FTAF, CAB) or No PrEP.",[19,20,21],"Drug: Emtricitabine\u002Ftenofovir disoproxil fumarate (F\u002FTDF)","Drug: Emtricitabine\u002Ftenofovir alafenamide (F\u002FTAF)","Drug: Cabotegravir (CAB)",[23,30,36,41,47],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","Lenacapavir Injection","Administered via subcutaneous (SC) injection",[9],[29],"YEZTUGO®",{"type":24,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Emtricitabine\u002Ftenofovir disoproxil fumarate (F\u002FTDF)","Tablets administered orally",[16],[35],"Truvada®",{"type":24,"name":37,"description":32,"armGroupLabels":38,"otherNames":39},"Emtricitabine\u002Ftenofovir alafenamide (F\u002FTAF)",[16],[40],"Descovy®",{"type":24,"name":42,"description":43,"armGroupLabels":44,"otherNames":45},"Cabotegravir (CAB)","Administered via intramuscular (IM) injection",[16],[46],"CAB",{"type":24,"name":48,"description":49,"armGroupLabels":50,"otherNames":10},"Lenacapavir Tablet","Administered orally",[9],[52],{"name":53,"affiliation":5,"role":54},"Gilead Study Director","STUDY_DIRECTOR",[56],{"name":57,"role":58,"phone":59,"phoneExt":10,"email":60},"Gilead Clinical Study Information Center","CONTACT","1-833-445-3230 (GILEAD-0)","GileadClinicalTrials@gilead.com",[62,76,86,95,104,113,123,133,139,148,158,168,178,188,198,208,217,227,237,246,256,265,275,284,294,304,310,319],{"facility":63,"status":64,"city":65,"state":66,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":10},"UAB 1917 Research Clinic","RECRUITING","Birmingham","Alabama","35222","United States","US",{"type":71,"coordinates":72},"Point",[73,74],-86.80249,33.52066,{"lat":74,"lon":73},{"facility":77,"status":64,"city":78,"state":79,"zip":80,"country":68,"countryCode":69,"cosmosGeoPoint":81,"geoPoint":85,"contacts":10},"Pacific Oaks Medical Group","Beverly Hills","California","90211",{"type":71,"coordinates":82},[83,84],-118.40036,34.07362,{"lat":84,"lon":83},{"facility":87,"status":64,"city":88,"state":79,"zip":89,"country":68,"countryCode":69,"cosmosGeoPoint":90,"geoPoint":94,"contacts":10},"Ruane Clinical Research Group Inc.","Los Angeles","90036",{"type":71,"coordinates":91},[92,93],-118.24368,34.05223,{"lat":93,"lon":92},{"facility":96,"status":64,"city":97,"state":79,"zip":98,"country":68,"countryCode":69,"cosmosGeoPoint":99,"geoPoint":103,"contacts":10},"Family Health Centers of San Diego","San Diego","92102",{"type":71,"coordinates":100},[101,102],-117.16472,32.71571,{"lat":102,"lon":101},{"facility":105,"status":64,"city":106,"state":79,"zip":107,"country":68,"countryCode":69,"cosmosGeoPoint":108,"geoPoint":112,"contacts":10},"Mills Clinical Research","West Hollywood","90046",{"type":71,"coordinates":109},[110,111],-118.36174,34.09001,{"lat":111,"lon":110},{"facility":114,"status":64,"city":115,"state":116,"zip":117,"country":68,"countryCode":69,"cosmosGeoPoint":118,"geoPoint":122,"contacts":10},"Vivent Health","Denver","Colorado","80246",{"type":71,"coordinates":119},[120,121],-104.9847,39.73915,{"lat":121,"lon":120},{"facility":124,"status":64,"city":125,"state":126,"zip":127,"country":68,"countryCode":69,"cosmosGeoPoint":128,"geoPoint":132,"contacts":10},"Bliss Health","Orlando","Florida","32803",{"type":71,"coordinates":129},[130,131],-81.37924,28.53834,{"lat":131,"lon":130},{"facility":134,"status":64,"city":125,"state":126,"zip":135,"country":68,"countryCode":69,"cosmosGeoPoint":136,"geoPoint":138,"contacts":10},"Pineapple Healthcare Orlando","32829",{"type":71,"coordinates":137},[130,131],{"lat":131,"lon":130},{"facility":140,"status":64,"city":141,"state":126,"zip":142,"country":68,"countryCode":69,"cosmosGeoPoint":143,"geoPoint":147,"contacts":10},"AHF - Pensacola","Pensacola","32503",{"type":71,"coordinates":144},[145,146],-87.21691,30.42131,{"lat":146,"lon":145},{"facility":149,"status":64,"city":150,"state":151,"zip":152,"country":68,"countryCode":69,"cosmosGeoPoint":153,"geoPoint":157,"contacts":10},"Faebris Medical & Community Education","Atlanta","Georgia","01111",{"type":71,"coordinates":154},[155,156],-84.38798,33.749,{"lat":156,"lon":155},{"facility":159,"status":64,"city":160,"state":161,"zip":162,"country":68,"countryCode":69,"cosmosGeoPoint":163,"geoPoint":167,"contacts":10},"Howard Brown Health","Chicago","Illinois","60613",{"type":71,"coordinates":164},[165,166],-87.65005,41.85003,{"lat":166,"lon":165},{"facility":169,"status":64,"city":170,"state":171,"zip":172,"country":68,"countryCode":69,"cosmosGeoPoint":173,"geoPoint":177,"contacts":10},"The Clinic NOLA","New Orleans","Louisiana","70115",{"type":71,"coordinates":174},[175,176],-90.07507,29.95465,{"lat":176,"lon":175},{"facility":179,"status":64,"city":180,"state":181,"zip":182,"country":68,"countryCode":69,"cosmosGeoPoint":183,"geoPoint":187,"contacts":10},"Chase Brexton Health Care","Baltimore","Maryland","21201",{"type":71,"coordinates":184},[185,186],-76.61219,39.29038,{"lat":186,"lon":185},{"facility":189,"status":64,"city":190,"state":191,"zip":192,"country":68,"countryCode":69,"cosmosGeoPoint":193,"geoPoint":197,"contacts":10},"Fenway Health","Boston","Massachusetts","02215",{"type":71,"coordinates":194},[195,196],-71.05977,42.35843,{"lat":196,"lon":195},{"facility":199,"status":64,"city":200,"state":201,"zip":202,"country":68,"countryCode":69,"cosmosGeoPoint":203,"geoPoint":207,"contacts":10},"Be Well Medical Center","Berkley","Michigan","48072",{"type":71,"coordinates":204},[205,206],-83.18354,42.50309,{"lat":206,"lon":205},{"facility":209,"status":64,"city":210,"state":201,"zip":211,"country":68,"countryCode":69,"cosmosGeoPoint":212,"geoPoint":216,"contacts":10},"Henry Ford Health","Detroit","48202",{"type":71,"coordinates":213},[214,215],-83.04575,42.33143,{"lat":215,"lon":214},{"facility":218,"status":64,"city":219,"state":220,"zip":221,"country":68,"countryCode":69,"cosmosGeoPoint":222,"geoPoint":226,"contacts":10},"The Aliveness Project","Minneapolis","Minnesota","55409",{"type":71,"coordinates":223},[224,225],-93.26384,44.97997,{"lat":225,"lon":224},{"facility":228,"status":64,"city":229,"state":230,"zip":231,"country":68,"countryCode":69,"cosmosGeoPoint":232,"geoPoint":236,"contacts":10},"KC Care Health Center","Kansas City","Missouri","64111",{"type":71,"coordinates":233},[234,235],-94.57857,39.09973,{"lat":235,"lon":234},{"facility":238,"status":64,"city":239,"state":230,"zip":240,"country":68,"countryCode":69,"cosmosGeoPoint":241,"geoPoint":245,"contacts":10},"Washington University School of Medicine Infectious Disease Clinical Research Unit","St Louis","63110",{"type":71,"coordinates":242},[243,244],-90.19789,38.62727,{"lat":244,"lon":243},{"facility":247,"status":64,"city":248,"state":249,"zip":250,"country":68,"countryCode":69,"cosmosGeoPoint":251,"geoPoint":255,"contacts":10},"University of Nebraska Medical Center\u002FNebraska Medicine Specialty Care Center","Omaha","Nebraska","68198",{"type":71,"coordinates":252},[253,254],-95.94043,41.25626,{"lat":254,"lon":253},{"facility":257,"status":64,"city":258,"state":258,"zip":259,"country":68,"countryCode":69,"cosmosGeoPoint":260,"geoPoint":264,"contacts":10},"NYC Health + Hospitals \u002F Bellevue","New York","10016",{"type":71,"coordinates":261},[262,263],-74.00597,40.71427,{"lat":263,"lon":262},{"facility":266,"status":64,"city":267,"state":268,"zip":269,"country":68,"countryCode":69,"cosmosGeoPoint":270,"geoPoint":274,"contacts":10},"University of Cincinnati College of Medicine","Cincinnati","Ohio","45267",{"type":71,"coordinates":271},[272,273],-84.51439,39.12711,{"lat":273,"lon":272},{"facility":276,"status":64,"city":277,"state":268,"zip":278,"country":68,"countryCode":69,"cosmosGeoPoint":279,"geoPoint":283,"contacts":10},"Ohio State University Infectious Diseases Clinical Trials Unit","Columbus","43210",{"type":71,"coordinates":280},[281,282],-82.99879,39.96118,{"lat":282,"lon":281},{"facility":285,"status":64,"city":286,"state":287,"zip":288,"country":68,"countryCode":69,"cosmosGeoPoint":289,"geoPoint":293,"contacts":10},"Perelman Center for Advanced Medicine","Philadelphia","Pennsylvania","19107",{"type":71,"coordinates":290},[291,292],-75.16362,39.95238,{"lat":292,"lon":291},{"facility":295,"status":64,"city":296,"state":297,"zip":298,"country":68,"countryCode":69,"cosmosGeoPoint":299,"geoPoint":303,"contacts":10},"Abounding Prosperity Inc.","Dallas","Texas","75215",{"type":71,"coordinates":300},[301,302],-96.80667,32.78306,{"lat":302,"lon":301},{"facility":305,"status":64,"city":296,"state":297,"zip":306,"country":68,"countryCode":69,"cosmosGeoPoint":307,"geoPoint":309,"contacts":10},"Prism Health","75246",{"type":71,"coordinates":308},[301,302],{"lat":302,"lon":301},{"facility":311,"status":64,"city":312,"state":297,"zip":313,"country":68,"countryCode":69,"cosmosGeoPoint":314,"geoPoint":318,"contacts":10},"UT Health","Houston","77009",{"type":71,"coordinates":315},[316,317],-95.36327,29.76328,{"lat":317,"lon":316},{"facility":320,"status":64,"city":321,"state":322,"zip":323,"country":68,"countryCode":69,"cosmosGeoPoint":324,"geoPoint":328,"contacts":10},"West Virginia Health Right, Inc.","Charleston","West Virginia","25302",{"type":71,"coordinates":325},[326,327],-81.63262,38.34982,{"lat":327,"lon":326},{"type":330,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100629369","implementation-study-of-lenacapavir-pre-exposure-prophylaxis-for-hiv-prevention-100629369",false,"NCT07473778","Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention","Pioneering Research to Optimize Pre-exposure Prophylaxis (PrEP) Expansion With Lenacapavir (LEN)","PROPEL","Key Inclusion Criteria:\n\n* Able to comprehend and provide a signed written informed consent, which must be obtained prior to initiation of screening study procedures;\n* Willing and able to comply with all study requirements;\n* Presents at a study site needing or wanting PrEP for HIV prevention as determined by local clinical practice guidelines and institutional protocols, including new PrEP users (PrEP naïve) and current or former users of oral (emtricitabine\u002Ftenofovir disoproxil fumarate (coformulated; Truvada®; F\u002FTDF) or emtricitabine\u002Ftenofovir alafenamide (coformulated; Descovy®; F\u002FTAF)) or injectable (LEN or cabotegravir (CAB)) PrEP who indicate interest in discussing PrEP methods that they are clinically eligible to receive;\n* Eligible for LEN PrEP per standard of care procedures, for example, being HIV-1 negative at screening using a Food and Drug Administration (FDA) approved\u002Fcleared test for diagnosis of acute or primary HIV-1 infection;\n* After PrEP counseling to learn about the advantages and disadvantages of various PrEP methods:\n\n  1. Selects LEN PrEP as their chosen PrEP method; OR,\n  2. Selects a different PrEP method or chooses not to start or continue PrEP.\n\nKey Exclusion Criteria:\n\n* Any other indication not already listed above that would make the participant ineligible for LEN PrEP at enrollment according to local guidelines, organizational protocols, US Prescribing Information (USPI) for the PrEP product, and\u002For Center for Disease and Control (CDC) guidance.\n\nNote: Other protocol defined Inclusion\u002FExclusion criteria may apply.","ALL","18 Years",{"count":342,"type":343},3000,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to generate real-life information on the use of lenacapavir (LEN, YEZTUGO®, (YTG)) for pre-exposure prophylaxis (PrEP) across diverse clinical settings in the United States. The study will characterize how PrEP is initiated, used, and discontinued in routine clinical practice when LEN is added as PrEP option and will evaluate persistence on LEN PrEP.\n\nThe primary objective of this study is to evaluate real-life persistence on LEN PrEP at Week 52 in diverse clinical settings in the United States.",[347],"HIV Infections","2026-06-26",{"date":350,"type":351},"2026-06-30","ACTUAL",{"date":353,"type":351},"2026-03-17",{"date":355,"type":343},"2029-04",{"name":5,"class":6},28]