[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614455":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":37,"locations":44,"responsibleParty":61,"collaborators":65,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":30,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":30,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":93,"whyStopped":30,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"The Hong Kong Polytechnic University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Transcutaneous Acupoints Electrical Stimulation (TAES)","EXPERIMENTAL","The intervention for TAES group will last 8 weeks, conducting 2 times per week, total covering 16 sessions. The intervention will be delivered a registered nurse with qualified TCM nurse certification. Four bilateral acupoints - Hegu, Shousanli , Zusanli, and Chongyang will be choosen. TAES will be deliveried by electronic acupunture treatment instrument with low frequency. Each session is 60 minutes.",[13],"Behavioral: Transcutaneous Acupoints Electrical Stimulation (TAES)",{"label":15,"type":10,"description":16,"interventionNames":17},"Auricular Acupressure (AA)","The AA subjects received auricular acupressure three times a day for two days every week for 8 weeks, total covering 16 sessions. Four acupoints including Shenmen (TF4), sympathetic (AH6a), fingers (SF1) and toes (AH2) will be choosen. A small piece of adhesive tape with vaccaria seed will be taped onto each selected auricular acupoint on a subject's ear.",[18],"Behavioral: Auricular Acupressure (AA)",{"label":20,"type":21,"description":22,"interventionNames":23},"Self-Managed control group","PLACEBO_COMPARATOR","Subjects shall receive leaflet containing self-help materials for CIPN which they can conduct by themself (self-management) and continue to receive their usual care from the hospital.",[24],"Other: No intervention",[26,31,34],{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"BEHAVIORAL","Transcutaneous Acupoints Electrical Stimulation (TAES) is a kind of physical therapy that use electric current through the electrodes placed on the surface of acupoints to produce clinical effects in the human body.",[9],null,{"type":27,"name":15,"description":32,"armGroupLabels":33,"otherNames":30},"Auricular acupressure (AA) is a non-invasive therapy rooted in Traditional Chinese Medicine (TCM) that involves applying pressure to specific acupoints on the ear using Vaccaria seeds.",[15],{"type":6,"name":35,"description":35,"armGroupLabels":36,"otherNames":30},"No intervention",[20],[38],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Ka Yan Ho, PhD","CONTACT","+85254844554","+85227666417","kyeva.ho@polyu.edu.hk",[45],{"facility":46,"status":30,"city":47,"state":30,"zip":30,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Shanghai Children Medical Center","Shanghai","China","CN",{"type":51,"coordinates":52},"Point",[53,54],121.45806,31.22222,{"lat":54,"lon":53},[57],{"name":58,"role":40,"phone":59,"phoneExt":30,"email":60},"Meng Xue He, PhD","(86)15702140512","hemx0321@163.com",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Dr Eva Ho","Associate professor",[66],{"name":67,"class":6},"Shanghai Children's Medical Center","100614455","improving-chemotherapy-induced-peripheral-neuropathy-in-children-with-leukemia-a-study-of-transcutaneous-acupoints-electrical-stimulation-and-auricular-acupressure-interventions-100614455",false,"NCT07279818","Improving Chemotherapy Induced Peripheral Neuropathy in Children With Leukemia: A Study of Transcutaneous Acupoints Electrical Stimulation and Auricular Acupressure Interventions","Effectiveness of Transcutaneous Acupoints Electrical Stimulation and Auricular Acupressure on Chemotherapy Induced Peripheral Neuropathy in Children With Leukemia: a Single Blind Randomized Controlled Study","Inclusion Criteria:\n\n* age between 8 and 17 years old\n* diagnosed with leukemia\n* received neurotoxic chemotherapy\n* have developed score 9 or above CIPN symptoms according to Pediatric Chemotherapy-Induced Neuropathy (P-CIN)\n* able to communicate and read Chinese\n\nExclusion Criteria:\n\n* receiving multiple cancer treatment\n* had a diagnosis of cancer in the central nervous system cancer, cancer relapse or secondary cancer\n* having other neuromuscular disorders, for example, traumatic brain injury and cerebral palsy\n* having other systematic diseases that cause toxicity in the peripheral nervous system, such as sickle cell disease (SCD), Guillain-Barre ́ Syndrome (GBS), anterior cutaneous nerve entrapment syndrome (ACNES), obstetric brachial plexus injury (OBPI), type I diabetes mellitus, postherpetic neuralgia (PHN), peroneal nerve injury, and reflex sympathetic dystrophy (RSD)\n* acupoints areas with injuries, wounds or allodynia\n* participated in any other CIPN non-pharmacological intervention programme\n* having any impaired bone marrow suppression, liver or renal function\n* contraindications to TEAS or auricular acupressure: such as having a pacemaker, skin infection, damage, or allergy to the electrodes\n* suffering from mental illness or using antipsychotic drugs\n* parents and children refused to give consent.","ALL","8 Years","17 Years",{"count":79,"type":80},132,"ESTIMATED","INTERVENTIONAL",[83],"NA","The goal of this clinical trial is to compare the effectiveness of Transcutaneous Acupoints Electrical Stimulation (TAES) and Auricular Acupressure (AA) on subject CIPN symptoms, sensory function, motor and physical function, psychological, physical symptoms and quality of life outcomes in Children with Leukemia.\n\nThe main questions it aims to answer are:\n\n1. Does TAES and AA can improve CIPN symptoms, sensory function, motor and physical function, psychological, physical symptoms and quality of life outcomes in children with Leukemia compared with self-management control group?\n2. Does TAES yield improvements in CIPN symptoms, sensory function, motor and physical function, psychological, physical symptoms and quality of life outcomes that are comparable to those achieved through AA in children with leukemia?\n\nThis proposed research is designed to conduct a three-arm RCT comparing TAES, AA to usual care in children with leukemia.\n\nSubjects in TAES group will receive 8 weeks TAES on four acupoints. Subjects in AA group will receive 8 weeks on four acupoints. Subjects in self-management control group will receive usual care they will receive from the hospital. These three groups will be provided with a leaflet containing self-help materials for CIPN.",[86],"Chemotherapy Induced Peripheral Neuropathy (CIPN)",[88,89,90,91,92],"Transcutaneous Acupoints Electrical Stimulation","Auricular Acupressure","chemotherapy induced peripheral neuropathy","Leukemia","children","NOT_YET_RECRUITING","2025-12-10",{"date":96,"type":97},"2025-12-12","ACTUAL",{"date":99,"type":80},"2025-12-08",{"date":101,"type":80},"2026-09-30",{"name":5,"class":6},1]