[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100408630":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":33,"centralContacts":43,"locations":51,"responsibleParty":82,"collaborators":84,"id":88,"slug":89,"hasResults":90,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":97,"minAge":98,"maxAge":32,"enrollmentInfo":99,"targetDuration":32,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":53,"whyStopped":32,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Trustees of Dartmouth College","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Surveillance with Technical Assistance","ACTIVE_COMPARATOR","Surveillance will be offered to 3 teams with Technical Assistance (TA) in block randomization. Surveillance tool will execute regularly updated reports (continually updated with laboratory data entry of ESKAPE pathogen isolation results), which generates a set of data that will populate series of tables and graphs for each site based on data collection form as previously reported.",[13],"Behavioral: Technical assistance or team-based coaching",{"label":15,"type":10,"description":16,"interventionNames":17},"Surveillance with EBIP Coaching","Surveillance will be offered to 3 teams with Evidence-Based Infection Prevention Bundle (EBIP) coaching in block randomization. Surveillance tool will execute regularly updated reports (continually updated with laboratory data entry of ESKAPE pathogen isolation results), which generates a set of data that will populate series of tables and graphs for each site based on data collection form as previously reported. EBIP involves evidence-based improvements in perioperative hand hygiene, environmental cleaning, vascular care, and patient decolonization. Each participating site will receive monthly team-based coaching to establish a multidisciplinary team charged with continuously improving transmission and infection prevention.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Technical Assistance No Surveillance","TA will be offered to 3 teams. TA will have monthly scheduled TA calls (60 minutes each) with each team individually to review and discuss the protocol interventions (as is done in the EBIP group) and allow for a consultation with experts on the peri-operative interventions. Surveillance toolkit will only be used for transmission data collection.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"EBIP Coaching No Surveillance","EBIP will be offered to 3 teams. Each participating site will receive monthly team-based coaching to establish a multidisciplinary team charged with continuously improving transmission and infection prevention. EBIP involves evidence-based improvements in perioperative hand hygiene, environmental cleaning, vascular care, and patient decolonization. Surveillance toolkit will only be used for transmission data collection.",[13],[27],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"BEHAVIORAL","Technical assistance or team-based coaching","Main comparison in delivering peri-operative preventive strategies against transmission and infection is one on one technical assistance or team-based coaching.",[23,15,9,19],null,[34,37,40],{"name":35,"affiliation":5,"role":36},"Jeremiah R Brown, PhD","PRINCIPAL_INVESTIGATOR",{"name":38,"affiliation":39,"role":36},"Randy Loftus, MD","Mayo Clinic",{"name":41,"affiliation":5,"role":42},"Ib en K Sullivan, PhD","STUDY_DIRECTOR",[44,48],{"name":35,"role":45,"phone":46,"phoneExt":32,"email":47},"CONTACT","603-646-5409","jbrown@dartmouth.edu",{"name":49,"role":45,"phone":32,"phoneExt":32,"email":50},"Iben Sullivan, PhD","Iben.K.Sullivan@dartmouth.edu",[52,68],{"facility":39,"status":53,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":60,"coordinates":61},"Point",[62,63],-92.4699,44.02163,{"lat":63,"lon":62},[66],{"name":38,"role":45,"phone":32,"phoneExt":32,"email":67},"randy-loftus@uiowa.edu",{"facility":5,"status":53,"city":69,"state":70,"zip":71,"country":57,"countryCode":58,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Hanover","New Hampshire","03755",{"type":60,"coordinates":73},[74,75],-72.28954,43.70229,{"lat":75,"lon":74},[78,79],{"name":35,"role":45,"phone":32,"phoneExt":32,"email":47},{"name":80,"role":45,"phone":32,"phoneExt":32,"email":81},"Meagan Stabler, PhD","Meagan.E.Stabler@dartmouth.edu",{"type":83,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[85,86],{"name":39,"class":6},{"name":87,"class":6},"Georgetown University","100408630","improving-implementation-of-evidence-based-approaches-and-surveillance-to-prevent-bacterial-transmission-and-infection-100408630",false,"NCT04600973","Improving Implementation of Evidence-based Approaches and Surveillance to Prevent Bacterial Transmission and Infection","The BASIC Trial: Improving Implementation of Evidence-based Approaches and Surveillance to Prevent Bacterial Transmission and Infection","BASIC","Site Inclusion and Exclusion Criteria.\n\n* 250 patients (125 case pairs) per site in the active phase (N=3,000)\n* 250 patients (125 case pairs) per site in the sustainability phase (N=3,000)\n* Total N=6,000\n* orthopedic total joint and spine procedures\n\nSite Inclusion Criteria:\n\n* operating room conducting orthopedic total joint and spine\n* Surgeons performing orthopedic total joint or spine\n\nSite Exclusion Criteria:\n\n\\- medical centers actively enrolling patients in a bacterial transmission or infection prevention trial\n\nPatient Inclusion Criteria:\n\n\\- all elective patients undergoing orthopedic total joint and spine\n\nExclusion Criteria:\n\n* no requirement for anesthesia and\u002For placement of a peripheral intravenous catheter\n* lack of incision or informed, written consent\n* an allergy to chlorhexidine\n* povidone iodine or isopropyl alcohol\n* ASA health classification status\\>5",true,"ALL","18 Years",{"count":100,"type":101},6000,"ESTIMATED","INTERVENTIONAL",[104],"NA","Surgical site infections (SSIs) are associated with increased patient morbidity, mortality, and healthcare costs. ESKAPE (Enterococcus, S. aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) pathogens are particularly pathogenic because they have increased capacity to acquire resistance and virulence traits. The investigators have proven that a multifaceted program involving improved basic perioperative preventive measures can generate substantial reductions in S. aureus transmission and significant reductions in SSIs (88% reduction as compared to usual care). In this study, the investigators aim to examine the relative effectiveness of each component of this program in controlling ESKAPE transmission and reducing SSIs and to identify an optimal implementation strategy for national dissemination. Randomization occurs at the site level, and sites adopt preventative programs. This work will improve perioperative patient safety for the 51 million patients who undergo surgery each year.",[107],"Infection",[109,110,111],"transmission","ESKAPE","prevention","2025-12-02",{"date":114,"type":115},"2025-12-03","ACTUAL",{"date":117,"type":115},"2021-07-01",{"date":119,"type":101},"2026-06-30",{"name":5,"class":6},2]