[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623822":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":55,"collaborators":57,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":18,"enrollmentInfo":73,"targetDuration":18,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":18,"overallStatus":41,"whyStopped":18,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"University of Bern","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Controlled Cannabis Administration","EXPERIMENTAL","Participants assigned to this arm receive a single, controlled inhalative administration of cannabis by smoking a THC-containing joint with a target dose of approximately 0.67 mg THC per kg body weight. Participants complete standardized driving sessions in an instrumented vehicle on a closed test track under sober baseline conditions and repeatedly after cannabis administration (approximately 1-6 hours post-dose). All driving sessions are conducted with a certified driving instructor seated in the front passenger seat with access to dual pedals, allowing immediate intervention if required. Multimodal in-vehicle sensor data, physiological signals, driving performance measures, and biological samples are collected throughout the study.",[13],"Drug: Cannabis (THC)",{"label":15,"type":16,"description":17,"interventionNames":18},"Reference (No Cannabis)","NO_INTERVENTION","Participants assigned to this reference arm receive no cannabis administration. They complete the same screening procedures, standardized driving sessions, assessments, and data collection as the experimental group under sober conditions, following the same schedule and time points. All driving sessions are conducted with a certified driving instructor seated in the front passenger seat with access to dual pedals, ensuring identical safety conditions. This arm serves as a non-impaired reference for comparison of driving behavior and in-vehicle sensor data.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DRUG","Cannabis (THC)","Participants assigned to the experimental arm receive a single, controlled inhalative administration of cannabis by smoking a THC-containing joint (target dose 0.67 mg THC per kg body weight; cannabis flowers with 15-18% THC).",[9],[26],{"name":27,"affiliation":28,"role":29},"Wolfgang Weinmann, Prof. Dr.","Institute for Forensic Medicine, Forensic Chemistry and Toxicology University of Bern","PRINCIPAL_INVESTIGATOR",[31,35],{"name":27,"role":32,"phone":33,"phoneExt":18,"email":34},"CONTACT","+41 31 684 01 61","wolfgang.weinmann@irm.unibe.ch",{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},"Michal Bechny, Dr.","+41 76 221 62 56","mbechny@ethz.ch",[40],{"facility":28,"status":41,"city":42,"state":18,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Bern","3008","Switzerland","CH",{"type":47,"coordinates":48},"Point",[49,50],7.44744,46.94809,{"lat":50,"lon":49},[53,54],{"name":27,"role":32,"phone":33,"phoneExt":18,"email":34},{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},{"type":56,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[58,60],{"name":59,"class":6},"ETH Zurich",{"name":61,"class":6},"University of St.Gallen","100623822","in-vehicle-real-time-cannabis-influenced-driving-detection-100623822",false,"NCT07401628","In-Vehicle Real-Time Cannabis Influenced Driving Detection","Randomised, Controlled, Interventional Single-center Study for the Design and Evaluation of an In-vehicle Real-time System for Detecting Cannabis-impaired Driving (CID)","REVELIO","Inclusion Criteria:\n\n* Informed consent as documented by signature\n* Recreational cannabis-consumption (more than once per month)\n* In possession of a definite Swiss or European Union (EU) driving license\n* At least 21 years old\n* Active, regular driving a car in the last 6 months\n* Must be in good health condition\n* No special equipment needed when driving (special seats, levers, etc.)\n* Fluent in (Swiss) German and no speech impairment\n\nExclusion Criteria:\n\n* Health concerns where cannabis consumption is contra-indicated (such as: high blood pressure, psychiatric problems (e.g. psychosis, depression, attention-deficit conditions, etc.)\n* Cannabis-abstinence or excessive consumption, , assessed using the Cannabis Use Disorders Identification Test-Revised (CUDIT-R)\n* For women: pregnancy or breastfeeding or if intention to become pregnant during study period (time between telephone screening and study day (visit 2)\n* Alcohol misuse or excessive alcohol consumption habits\u002Frisky drinking behaviour, assessed using the Alcohol Use Disorders Identification Test (AUDIT) and\u002For phosphatidylethanol (PEth) in capillary blood \\> 200 ng\u002FmL at first visit\n* If breath alcohol test is positive at Visit 1 or Visit 2 (study day)\n* Consumption of drugs of abuse (others than cannabis) within 4 weeks before the study\n* Consumption of medications \u002F pharmaceutical drugs which interfere with driving ability\n* Inability to follow the procedures of the study, e.g., due to language",true,"ALL","21 Years",{"count":74,"type":75},45,"ESTIMATED","INTERVENTIONAL",[78],"NA","The goal of this clinical trial is to evaluate whether in-vehicle sensor data can be used to detect cannabis-impaired driving in healthy adult recreational cannabis users.\n\nThe study aims to assess whether changes in vehicle, driver, and physiological sensor data can distinguish sober driving from cannabis-impaired driving, and how driving performance changes from baseline to approximately 1 to 6 hours after controlled cannabis consumption.\n\nResearchers will compare driving behavior and in-vehicle sensor data from participants who receive controlled cannabis administration with data from a randomized reference group without cannabis exposure, to determine whether cannabis-related impairment driving can be identified on the basis of machine learning.\n\nParticipants will complete screening and baseline assessments and drive an instrumented vehicle on a closed test track under sober conditions. Participants assigned to the experimental arm will receive controlled cannabis administration, while participants in the reference arm will receive no intervention. All participants will perform repeated standardized driving sessions over several hours and complete traffic-medical, traffic-psychological, and in-vehicle pre-driving tests. Biological samples and in-vehicle sensor data will be collected throughout the study.",[81,82],"Driving Under the Influence","Cannabis-impaired Driving","2026-02-03",{"date":85,"type":86},"2026-02-10","ACTUAL",{"date":88,"type":86},"2026-01-05",{"date":90,"type":75},"2026-06-19",{"name":5,"class":6},1]