[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100473213":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":27,"centralContacts":32,"locations":39,"responsibleParty":66,"collaborators":10,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":10,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":41,"whyStopped":10,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Fundacao Champalimaud","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Current major depressive episode group",null,"Adult individuals (18-65 yrs) diagnosed with current major depressive episode (MDE), under treatment or medication naif, starting a new antidperessant strategy (n≈30).",[13],"Other: No intervention\u002Fexpousure",{"label":15,"type":10,"description":16,"interventionNames":17},"Maintenance antidepressant treatment group","Adult individuals (18-65 yrs) previously diagnosed with major depressive episode (MDE) currently remitted under continuation or maintenance antidepressant treatment (n≈30).",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Healthy subjects group","Adult individuals (18-65 yrs) without current diagnosis of major neuropsychiatric disorders, inlcluding MDE, hence not under any antidepressant medication. The same exclusion criteria will be applied as in the two clincial groups.",[13],[23],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"No intervention\u002Fexpousure","No interventions\u002Fexpousure since this is an observational study.",[9,19,15],[28],{"name":29,"affiliation":30,"role":31},"Albino J Oliveira-Maia, MD, MPH, PhD","Champalimaud Foundation","PRINCIPAL_INVESTIGATOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Sofia Marques","CONTACT","00351 210480048","4153","sofia.marques@research.fchampalimaud.org",[40],{"facility":30,"status":41,"city":42,"state":10,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Lisbon","1400-038","Portugal","PT",{"type":47,"coordinates":48},"Point",[49,50],-9.1498,38.72509,{"lat":50,"lon":49},[53,54,55,58,60,62,64],{"name":34,"role":35,"phone":10,"phoneExt":10,"email":38},{"name":29,"role":31,"phone":10,"phoneExt":10,"email":10},{"name":56,"role":57,"phone":10,"phoneExt":10,"email":10},"Gonçalo Cotovio, MD","SUB_INVESTIGATOR",{"name":59,"role":57,"phone":10,"phoneExt":10,"email":10},"Daniel Rodrigues da Silva, MSc",{"name":61,"role":57,"phone":10,"phoneExt":10,"email":10},"Francisco Faro Viano",{"name":63,"role":57,"phone":10,"phoneExt":10,"email":10},"Patricia Pereira, MSc",{"name":65,"role":57,"phone":10,"phoneExt":10,"email":10},"Carolina Seybert, PhD",{"type":31,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Albino Maia","Director of Neuropsychiatry Unit, Champalimaud Foundation","100473213","in-vivo-cortical-excitability-modulation-in-major-depressive-disorder-100473213",false,"NCT05441969","In Vivo Cortical Excitability Modulation in Major Depressive Disorder","PDM-TMS","Inclusion criteria (clinical groups):\n\n1\\. Diagnosis of major depressive episode or disorder as provided in the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) (American Psychiatric Association. 2013).\n\nExclusion criteria (clinical groups):\n\n1. Moderate to severe suicide risk;\n2. Known personal history of bipolar disorder or psychotic disorder;\n3. Alcohol or other substance abuse and\u002For dependence;\n4. Developmental disorder;\n5. Dementia;\n6. Presence of uncontrolled active medical illness;\n7. Known structural lesion of the central nervous system;\n8. Electrical or metallic brain implants;\n9. Cardiac implants;\n10. Epilepsy;\n11. Active use of medication known to cause seizures;\n12. Pregnancy;\n13. Breastfeeding.\n\nFor the healthy control group, participants will also be recruited at the Champalimaud Clinical Center, by advertisement in places of public circulation. The recruitment of this population will be done in order to generate a pairing with both clinical groups in terms of age and sex. The same exclusion criteria will be applied, as well as the presence of any history of neuropsychiatric disease. The total number of participants for this study will be approximately 90 volunteers. Exclusion criteria will be assessed through self-report and\u002For MINI.",true,"ALL","18 Years","65 Years",{"count":81,"type":82},90,"ESTIMATED","OBSERVATIONAL","The pathophysiology of Major Depression Disorder (MDD) is unclear, with several theories for its neurobiological mechanisms. One possible explanation is the presence of altered neuroplasticity, which can be studied by Transcranial Magnetic Stimulation (TMS). Using TMS to study these mechanisms is performed by applying electromagnetic stimuli to the motor cortex, to obtain measures of temporary cortical excitability modulation. It is known that depressed patients with higher cortical modulation are more responsive to a TMS treatment course. However, it is unknown if there are differences in cortical modulation between depressed patients and healthy subjects. Our goal is to answer this question and contribute towards clarification of the neuroplasticity mechanisms underlying MDD. Accordingly, the investigators will access cortical excitability modulation measures in both depressed patients and healthy volunteers and compare their results. The investigators will also re-assess these measures after 6 weeks of antidepressant treatment. Finally, the investigators will study the association between cortical excitability measures and cognitive processes using an innovative cognitive task.",[86],"Major Depressive Disorder",[86,88,89],"Cortical Excitability Modulation","Transcranial Magnetic Stimulation","2025-02-24",{"date":92,"type":93},"2025-02-26","ACTUAL",{"date":95,"type":93},"2020-05-19",{"date":97,"type":82},"2025-12-31",{"name":5,"class":6},1]